Epidemiology of Community-Acquired Sepsis in Adult Patients: A Six Year Observational Study

Grozdanovski, Krsto; Milenkovikj, Zvonko; Demiri, Ilir; Spasovska, Katerina; Cvetanovska, Marija; Saveski, Velimir; Grozdanovska, Biljana

doi:10.2478/prilozi-2018-0024

Cited by 6 publications

(9 citation statements)

References 39 publications

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“…After searching the electronic databases, 18001 publications were retrieved. Following thorough examination according to the inclusion and exclusion criteria, 10 studies (35712 patients in total) published between 2012 and 2021 were finally included in the meta-analysis[ 4 , 6 , 9 , 11 , 12 , 19 - 23 ]. A PRISMA flow chart of the study is presented in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The main characteristics of the included studies are reported in Table 1 . Of the ten included studies, five studies were conducted in the United States[ 4 , 6 , 11 , 12 , 22 ] and the remaining five studies were from the Republic of China[ 9 ], Macedonia[ 19 ], France[ 20 ], Israel[ 21 ] and Japan[ 23 ]. Three of the studies were prospective studies[ 4 , 19 , 20 ] and the other seven were retrospective studies[ 6 , 9 , 11 , 12 , 21 - 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…Of the ten included studies, five studies were conducted in the United States[ 4 , 6 , 11 , 12 , 22 ] and the remaining five studies were from the Republic of China[ 9 ], Macedonia[ 19 ], France[ 20 ], Israel[ 21 ] and Japan[ 23 ]. Three of the studies were prospective studies[ 4 , 19 , 20 ] and the other seven were retrospective studies[ 6 , 9 , 11 , 12 , 21 - 23 ]. Seven studies included intensive care unit (ICU) patients[ 6 , 9 , 12 , 19 - 21 , 23 ], and two studies were based on relevant databases[ 21 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…Three of the studies were prospective studies[ 4 , 19 , 20 ] and the other seven were retrospective studies[ 6 , 9 , 11 , 12 , 21 - 23 ]. Seven studies included intensive care unit (ICU) patients[ 6 , 9 , 12 , 19 - 21 , 23 ], and two studies were based on relevant databases[ 21 , 23 ]. Three studies included patients admitted to general Medicare hospitals[ 4 , 11 , 22 ], one of which was based on the healthcare system database[ 4 ].…”

Section: Resultsmentioning

confidence: 99%

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Impact of heart failure on outcomes in patients with sepsis: A systematic review and meta-analysis

Zhu¹,

Tang²,

Gao³

et al. 2023

World J Clin Cases

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BACKGROUND Heart failure (HF) often affects the progress of sepsis patients, although its impact on outcomes is inconsistent and inconclusive. AIM To conduct a systematic review and meta-analysis of the impact of HF on mortality in patients with sepsis. METHODS PubMed, Embase, Web of Science, and the Cochrane Library databases were searched to compare the outcomes of sepsis patients with HF. A random effect model was used to summarize the mortality data, and the odds ratio (OR) and 95% confidence interval (CI) were calculated as effect indicators. RESULTS Among 18001 records retrieved in the literature search, 35712 patients from 10 separate studies were included. The results showed that sepsis patients with HF were associated with increased total mortality (OR = 1.80, 95%CI: 1.34-2.43; I 2 = 92.1%), with high heterogeneity between studies. Significant subgroup differences according to age, geographical location, and HF patient sample were observed. HF did not increase the 1-year mortality of patients (OR = 1.11, 95%CI: 0.75-1.62; I 2 = 93.2%), and the mortality of patients with isolated right ventricular dysfunction (OR=2.32, 95%CI: 1.29-4.14; I 2 = 91.5%) increased significantly. CONCLUSION In patients with sepsis, HF is often associated with adverse outcomes and mortality. Our results call for more high-quality research and strategies to improve outcomes for sepsis patients with HF.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Impact of heart failure on outcomes in patients with sepsis: A systematic review and meta-analysis

Zhu¹,

Tang²,

Gao³

et al. 2023

World J Clin Cases

View full text Add to dashboard Cite

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“…One retrospective study included 22,354 sepsis patients found that COPD was associated with 60-day mortality [6]. On the contrary, a number of multicenter studies had reported that COPD is not the risk factor associated with hospitalized mortality in septic patients [7][8][9][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Association between chronic obstructive pulmonary disease and 28-day mortality in patients with sepsis: a retrospective study based on the MIMIC-III database

Chen,

Lu,

et al. 2023

Preprint

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Background: Along with a variety of chronic co-morbid medical conditions, sepsis is a common cause of mortality in critically ill patients, and chronic obstructive pulmonary disease (COPD) is one of the most common comorbidities in septic patients. However, the impact of COPD on patients with sepsis is still unclear. Therefore, the purpose of this study was aimed to assess the effect of COPD on the prognosis of sepsis patients based on MIMIC-III database. Methods: In this retrospective study based on the Medical Information Mart for Intensive Care (MIMIC)-III database version 1.4 (v1.4), we collected clinical data and 28-day all-cause mortality from sepsis patients in intensive care unit (ICU) who met the diagnostic criteria of Sepsis 3 on ICU admission between 2008 and 2012. ICD-9 code was used to identified COPD. We applied Kaplan-Meier analysis to compare difference between 28-day all-cause mortality of COPD and non-COPD patients. Univariate and multivariate cox proportional-hazards model was applied to explore the risk factor associated with 28-day all-cause mortality in patients with sepsis. Results: 6257 patients with sepsis were included in this study, including 955 (15.3%) with COPD and 5302 without COPD (84.7%). Compared with sepsis patients without COPD, sepsis patients with COPD were older (median: 73.5 vs 65.8, P<0.001), had a higher simplified acute physiology score II (SAPSII) (median: 40.0 vs 38.0, P<0.001) and greater proportion of mechanical ventilatory support (MV) (55.0% vs 48.9%, P=0.001). In our study, patients with COPD had higher 28-day all-cause mortality (23.6% vs 16.4%, P < 0.001) than non-COPD patients. After adjusting the confounding factors, the results showed that COPD was an independent risk factor for the 28-day all-cause mortality in septic patients (HR 1.30, 95%CI: 1.12-1.51, P=0.001). Conclusions: The comorbidity of COPD was an independent predictor of 28-day all-cause mortality in critical septic patients. Clinically, sepsis patients with COPD should be given additional care.

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Serum Neopterin and its Significance as Biomarker in Differentiation of Mods From Sepsis

Zhang

Chen

et al. 2018

Pteridines

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Objective The aim of this study was to evaluate the dynamic changes of serum neopterin and its significance as biomarker in differentiation of MODS from sepsis. Methods Fifty eight critical illness patients and 21 healthy controls were included in the study. Of the included 58 critical illness patients, 37 cases were diagnosed of sepsis (sepsis group) and other 21 were non-sepsis subjects (non-sepsis group). Of the 37 sepsis patients, 17 were diagnosed of multiple organ dysfunction syndrome (MODS group). The serum level of neopterin of the above subjects were examined by enzyme linked immunosorbent assay and compared between groups. Results The serum level of neopterin were 0.885±0.34(ng/mL), 3.77±2.08(ng/mL), 14.80±6.78(ng/mL) and 23.90±11.26(ng/mL) for healthy control, non-sepsis, non-MODS and MODS groups respectively with significant statistical difference (F=52.71, p<0.001). Serum neopterin level of non-sepsis, non-MODS and MODS groups were statistical different in the time points of 0, 24h, 48h, 72h, and 96h (p<0.05). The serum neopterin level was significant higher in MODS group compared to nonsepsis and non-MODS groups (p<0.05). Using the serum neopterin as biomarker in differentiation of MODS from sepsis, the diagnostic sensitivity, specificity and AUC were 70.59% (95%CI:44.04-89.69) %, 80.00% (95%CI:56.34- 94.27)% and 0.74(95%CI:0.57-0.91)% respectively. Conclusion Serum neopterin levels in patients with sepsis were elevated and can be used as a promising biomarker in differentiation of MODS from sepsis.

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Epidemiology of Community-Acquired Sepsis in Adult Patients: A Six Year Observational Study

Cited by 6 publications

References 39 publications

Impact of heart failure on outcomes in patients with sepsis: A systematic review and meta-analysis

Impact of heart failure on outcomes in patients with sepsis: A systematic review and meta-analysis

Association between chronic obstructive pulmonary disease and 28-day mortality in patients with sepsis: a retrospective study based on the MIMIC-III database

Serum Neopterin and its Significance as Biomarker in Differentiation of Mods From Sepsis

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