1998
DOI: 10.1093/oxfordjournals.aje.a009384
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Epidemiology of Congenital Cytomegalovirus Infection: Maternal Risk Factors and Molecular Analysis of Cytomegalovirus Strains

Abstract: To determine factors that influence the occurrence of congenital cytomegalovirus (CMV) infection, the authors surveyed prospectively 8,254 infants born in eastern Iowa between October 1989 and June 1994. The authors conducted a case-control study to identify maternal risk factors, matching each CMV-infected infant with three uninfected infants according to hospital and date of birth. CMV strains were compared by using the polymerase chain reaction (PCR) to identify common sources of infection. Of the 7,229 inf… Show more

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Cited by 71 publications
(53 citation statements)
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“…HCMV strains studied by STR were analyzed by PCR-based methods and primers for the a sequence, gB, MIE, and UL144 HCMV gene regions using methods described previously (3,15,18). Strains were considered distinct if they displayed differences in the a sequence amplicon size, gB genotype, or MIE RFLP, or had Ïœ95% homology by UL144 or a-sequence nucleotide DNA sequences.…”
Section: Methodsmentioning
confidence: 99%
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“…HCMV strains studied by STR were analyzed by PCR-based methods and primers for the a sequence, gB, MIE, and UL144 HCMV gene regions using methods described previously (3,15,18). Strains were considered distinct if they displayed differences in the a sequence amplicon size, gB genotype, or MIE RFLP, or had Ïœ95% homology by UL144 or a-sequence nucleotide DNA sequences.…”
Section: Methodsmentioning
confidence: 99%
“…We next compared isolates that were predicted to be similar based on geographic proximity (Table 4). These consisted of isolates from children attending a Cedar Rapids center (isolates 902, 916A, 90003, 90022B, and 90064) and isolates from congenitally infected children (isolates 4006000 and 4003280); the latter isolates were suspected by prior molecular analysis to be linked to the Cedar Rapids center (15). Each of the congenitally infected infants was born in Cedar Rapids and had siblings who attended the Cedar Rapids center during their mother's pregnancy.…”
Section: Methodsmentioning
confidence: 99%
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“…Previous studies [4] used a clinical isolate of CMV (a gB1 subtype). Of the four glycoprotein B subtypes of CMV, gB1 and gB3 are the most common types infecting children [14].…”
Section: Introductionmentioning
confidence: 99%
“…2,10 The prevalence of this infection in our region is not yet known. A number of studies performed in Brazil have observed prevalence rates that vary, depending on study population, from 0.39 to 6.8%.…”
Section: Introductionmentioning
confidence: 94%