Epidemiology of conventional cardiovascular risk factors among hypertensive subjects with normal and impaired fasting glucose

Akintunde, Adeseye A

doi:10.7196/samj.3180

Cited by 18 publications

(17 citation statements)

References 25 publications

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“…[8,9,10] This may be promoted and enhanced by mutable cardiovascular risk factors such as diet, physical inactivity and immutable risk factors like age, sex and ethnicity. [31,32] The finding of this study therefore portends a possible increase in the incidence of type 2 diabetes mellitus among adult Nigerians with essential hypertension and underscores the need to critically assess these patients during clinical encounter in primary care setting for pre-diabetes. This will help to reduce the health costs associated with management of their hypertensive condition and possible concurrent type 2 diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

“…[6,29] This is also explained in the constellation of abnormalities linking type 2 diabetes mellitus, hypertension and others constellations of metabolic syndrome. [8,32] Pre-diabetes induce changes in the cardiovascular system leading to cardiovascular diseases and it has been shown to be most pathologically relevant in the aetiopathogenesis of type 2 diabetes mellitus. [32] The strategies to reduce the risk and burden of type 2 diabetes mellitus in adult Nigerians with essential hypertension should therefore focus on control of prediabetes which is largely modifiable.…”

Section: Discussionmentioning

confidence: 99%

“…[8,32] Pre-diabetes induce changes in the cardiovascular system leading to cardiovascular diseases and it has been shown to be most pathologically relevant in the aetiopathogenesis of type 2 diabetes mellitus. [32] The strategies to reduce the risk and burden of type 2 diabetes mellitus in adult Nigerians with essential hypertension should therefore focus on control of prediabetes which is largely modifiable. [23] The earlier in the pre-morbid phase that pre-diabetes is detected in adult hypertensive patients, the better the prognosis and outcome of its management.…”

Section: Discussionmentioning

confidence: 99%

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Magnitude of Pre-Diabetes among Adult Nigerians with Essential Hypertension in a Primary Care Clinic of a Tertiary Hospital in South-Eastern, Nigeria

Iloh¹,

Uchenna²

2014

EJPM

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Abstract:Background: Hypertension co-existing with Diabetes mellitus is increasing globally. However, current evidence has demonstrated the existence of a prolonged, intermediate phase of diabetes termed pre-diabetes in hypertensive patients. Aim: This study was designed to determine the magnitude of pre-diabetes among adult Nigerians with essential hypertension in a primary care clinic of a tertiary hospital in South-eastern, Nigeria. Materials and Methods: A crosssectional analytic study carried out on 320 adult hypertensive Nigerians who were age and sex matched with 320 nonhypertensive, non-diabetic control group at the primary care clinic of a tertiary hospital in South-eastern Nigeria. These patients were screened for pre-diabetes. Pre-diabetes was defined as fasting plasma glucose of 100-125 mg/dL and /or plasma glucose level of 140-199 mg/dL two hours after a 75g oral glucose load. Hypertension was defined as systolic and/or diastolic blood pressures ≥140/90 mmHg or documented use of antihypertensive medications in a previously diagnosed person with hypertension. Results: The prevalence of pre-diabetes was significantly higher in hypertensive patients (33.1%) than control (16.2%) (p= 0.001) with impaired fasting glycaemia ((29.4%) being the more common pattern. The mean fasting plasma glucose of the hypertensive patients (122.4mg/dL±1.7)) was significantly higher than that of the control (91.8mg/dL±2.4) (p=0.000). Similarly, the mean two hours oral glucose load of the hypertensive patients (183.4mg/dL±1.6) was significantly higher than that of the control (161.8mg/dL±1.9)(p=0.001). Conclusion: This study has shown the existence of pre-diabetes among the hypertensive patients with impaired fasting glycaemia being the more common pattern. Screening adult Nigerians with essential hypertension for pre-diabetes should constitute clinical targets for intervention in primary care clinic.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Magnitude of Pre-Diabetes among Adult Nigerians with Essential Hypertension in a Primary Care Clinic of a Tertiary Hospital in South-Eastern, Nigeria

Iloh¹,

Uchenna²

2014

EJPM

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“…8 Not only hypertensive patients with diabetes, but also hypertensive patients without overt diabetes tend to be resistant to insulin stimulated glucose uptake compared with normotensive people. 1 It has been observed that about 20% of patients with hypertension having impaired fasting glycaemia will develop type 2 diabetes in a period of 3 years.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Hypertension is one of the leading causes of morbidity and mortality worldwide. 3 The concomitant occurrence of type 2 diabetes-mellitus leads to a further significant increase in this risk.…”

Section: Introductionmentioning

confidence: 99%

Effect of telmisartan in hypertensive patients with impaired fasting glycaemia

Mattam

Bano

Meenakumari

et al. 2017

Int J Basic Clin Pharmacol

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Background: Telmisartan, an angiotensin II receptor blocker, has a higher affinity for AT1 receptors. It has also been recognized as partial agonist of the nuclear hormone receptor PPAR-gamma. The present study is conducted to study the effect of Telmisartan in hypertensive patients with impaired fasting glycaemia.Methods: This is a prospective and randomised study done on 50 hypertensive patients with impaired fasting glycaemia. All the patients underwent following investigations like Fasting plasma glucose, blood pressure and body mass index were also measured.Results: Fasting plasma glucose, blood pressure (SBP, DBP) showed significant decrease after intake of 40 mg Telmisartan for three months. Changes in BMI are not significant.Conclusions: The present study shows that Telmisartan is effective in controlling blood-pressure by its AT1 receptor blocking activity. It is also effective in decreasing fasting blood glucose by its insulin sensitizing activity through partial peroxisome proliferator activated receptor (PPAR) gamma activity.

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Serum Lipid Profile of Newly Diagnosed Hypertensive Patients in Nnewi, South-East Nigeria

Osuji

Omejua

Onwubuya

et al. 2012

International Journal of Hypertension

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Abnormalities in serum lipid and lipoprotein levels are recognized major modifiable cardiovascular disease and essential hypertension risk factors. The objective of this study was to examine the serum lipid patterns of newly diagnosed hypertensive patients attending a tertiary healthcare centre in South East Nigeria. Methods. Two hundred and fifty newly diagnosed adult hypertensive patients and an equal number of age- and sex-matched controls without hypertension were consecutively recruited from the Medical and General Outpatient Clinics of Nnamdi Azikiwe University Teaching Hospital, Nnewi. Result. 126 males and 124 females were in each of the two groups. Mean age was comparable in both groups. Hypertensives had significantly higher mean systolic blood pressure, diastolic blood pressure, body mass index, waist circumference, waist-hip ratio, and fasting blood sugar than the controls. The mean TC, TG, and LDL-C were significantly higher among the hypertensives. The mean HDL-C was comparable; P = 0.8. Among the hypertensive subjects, there was statistically significant positive correlation between BMI and TC; LDL-C and TG; WC and TG; FBS and TC; LDL-C and TG. HDL-C showed a statistically significant inverse correlation with WHR in hypertensives. Conclusion. This study showed that lipid abnormalities are highly prevalent among newly diagnosed hypertensives in South-East Nigeria.

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Epidemiology of conventional cardiovascular risk factors among hypertensive subjects with normal and impaired fasting glucose

Cited by 18 publications

References 25 publications

Magnitude of Pre-Diabetes among Adult Nigerians with Essential Hypertension in a Primary Care Clinic of a Tertiary Hospital in South-Eastern, Nigeria

Magnitude of Pre-Diabetes among Adult Nigerians with Essential Hypertension in a Primary Care Clinic of a Tertiary Hospital in South-Eastern, Nigeria

Effect of telmisartan in hypertensive patients with impaired fasting glycaemia

Serum Lipid Profile of Newly Diagnosed Hypertensive Patients in Nnewi, South-East Nigeria

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