Epidemiology of dementia in Asia: Insights on prevalence, trends and novel risk factors

Catindig, Joseree-Ann S.; Venketasubramanian, Narayanaswamy; Ikram, M. Kamran; Chen, Christopher

doi:10.1016/j.jns.2012.07.023

Cited by 113 publications

(93 citation statements)

References 54 publications

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“…27 The prevalence of dementia in Asia has previously been reported to be lower than that in Western populations, but agespecific prevalence rates are similar globally. 28, 29 Overall, dementia prevalence is expected to rise dramatically across Asia due to increasingly elderly populations.…”

Section: Sci and The Risk Of Dementia And Cognitive Declinementioning

confidence: 99%

Silent Cerebral Infarction in East Asian vs. Non-Asian Atrial Fibrillation Patients　― Meta-Analysis ―

Senoo

Kondo

Kobayashi

et al. 2018

Circ J

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AF is also a well-established risk factor for dementia. For example, Liao et al reported a consistently higher rate of cognitive decline and risk of dementia in patients with AF. 11 These associations are partly due to the increased risk of clinical stroke in AF, but other mechanisms are likely to contribute, including the occurrence of SCI and microbleeds. 12 Current evidence is not sufficient to support a trend of increased prevalence of dementia in East Asia over the last few decades, but AF may contribute to dementia risk. We conducted a meta-analysis to compare the association of AF and SCI between East Asian and non-Asian patients. Methods Data SourcesPubMed were searched from their inception to 7 October 2017. No language restriction was applied. To ensure a comprehensive search of the literature, we also manually A trial fibrillation (AF) is the most common cardiac arrhythmia 1 and a major cause of stroke. The estimated global prevalence of AF is approximately 1-2%. 2 In Asia, the prevalence of AF has been reported to be slightly lower than that in Western populations. 3,4 Due to the much larger population in Asia, the burden of AF is estimated to be much greater in Asian than in Western populations. Indeed, it has been estimated that in 2050 there will be 72 million patients with AF in Asia, 4 more than double the combined number of patients from Europe and the USA. 1,5 Therefore, it is particularly important that AF is effectively managed in the ageing population of Asia.Silent cerebral infarction (SCI) is defined as the presence of cerebral infarction with the absence of corresponding clinical symptoms. In a recent meta-analysis, AF was associated with a more than 2-fold increased risk for SCI. 6 Several studies have reported an association between AF and increased risk of SCI in East Asian countries, 7-10 with the presence of SCI predicting subsequent clinically overt stroke. Thus, the prevalence of SCI and its effect as a risk factor for overt stroke are important considerations during the evaluation of AF.

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Section: Sci and The Risk Of Dementia And Cognitive Declinementioning

confidence: 99%

Silent Cerebral Infarction in East Asian vs. Non-Asian Atrial Fibrillation Patients　― Meta-Analysis ―

Senoo

Kondo

Kobayashi

et al. 2018

Circ J

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show abstract

“…Dementia prevalence is estimated to rise considerably across Asia [1][2][3], as the elderly population is projected to increase from the current 10% to 24% of the total Asian population by 2050 [4][5][6][7]. This significant increase in prevalence of dementia is of immediate medical and social concern for Asian countries since cognitive decline is often associated with loss of independent function [8], loss of employment, and additional burden to family members and the healthcare system [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

A novel language-neutral Visual Cognitive Assessment Test (VCAT): validation in four Southeast Asian countries

Lim

Ong

et al. 2018

Alz Res Therapy

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“…CeVD is recognized as a major contributor to cognitive impairment and dementia, especially in Asian populations. [1][2][3] Although a growing body of evidence suggests that MRI markers of CeVD can predict cognitive decline, previous studies investigating CeVD and neurocognitive function have mainly focused on either the association between (1) ischemic stroke and cognition or (2) SVD and cognition. [4][5][6] However, the concept of total CeVD burden, encompassing both SVD and LVD, has not been extensively examined in relation to cognitive status.…”

mentioning

confidence: 99%

Association of Magnetic Resonance Imaging Markers of Cerebrovascular Disease Burden and Cognition

Hilal

Collinson

et al. 2015

Stroke

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Background and Purpose-The present study sought to examine the association between the burden of cerebrovascular disease (CeVD) as assessed by multimodal magnetic resonance imaging and neurocognitive function. Methods-Cognitively impaired patients and controls were tested on an extensive neuropsychological battery and underwent multimodal brain magnetic resonance imaging. CeVD markers determined from magnetic resonance imaging included the presence of multiple lacunes, multiple cerebral microbleeds, and moderate or severe white matter hyperintensities as markers for small-vessel disease and cortical stroke and intracranial stenosis as markers for large-vessel disease. A weighted CeVD burden score was constructed, and its association with global and domain-specific cognitive performance was investigated. Results-A total of 305 cases and 94 controls were included in the analysis. A graded association of CeVD burden with neurocognitive function was found. Moreover, a clear threshold of CeVD burden was associated with severe impairment. White matter hyperintensities was associated with global neurocognitive deficits, whereas microbleeds were associated with domain-specific impairments. Conclusions-The weighted CeVD burden score comprising markers of both small-and large-vessel diseases were associated with deficits in both global and domain-specific neurocognitive function. Additional studies are needed to validate the use of this CeVD burden score for the prediction of dementia.

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Epidemiology of dementia in Asia: Insights on prevalence, trends and novel risk factors

Cited by 113 publications

References 54 publications

Silent Cerebral Infarction in East Asian vs. Non-Asian Atrial Fibrillation Patients　― Meta-Analysis ―

Silent Cerebral Infarction in East Asian vs. Non-Asian Atrial Fibrillation Patients　― Meta-Analysis ―

A novel language-neutral Visual Cognitive Assessment Test (VCAT): validation in four Southeast Asian countries

Association of Magnetic Resonance Imaging Markers of Cerebrovascular Disease Burden and Cognition

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Epidemiology of dementia in Asia: Insights on prevalence, trends and novel risk factors

Cited by 113 publications

References 54 publications

Silent Cerebral Infarction in East Asian vs. Non-Asian Atrial Fibrillation Patients ― Meta-Analysis ―

Silent Cerebral Infarction in East Asian vs. Non-Asian Atrial Fibrillation Patients ― Meta-Analysis ―

A novel language-neutral Visual Cognitive Assessment Test (VCAT): validation in four Southeast Asian countries

Association of Magnetic Resonance Imaging Markers of Cerebrovascular Disease Burden and Cognition

Contact Info

Product

Resources

About

Silent Cerebral Infarction in East Asian vs. Non-Asian Atrial Fibrillation Patients　― Meta-Analysis ―

Silent Cerebral Infarction in East Asian vs. Non-Asian Atrial Fibrillation Patients　― Meta-Analysis ―