Epidemiology of dengue fever in Guatemala

Signor, Leticia del Carmen Castillo; Edwards, Thomas; Escobar, Luis E.; Mencos, Yolanda; Matope, Agnes; Castaneda-Guzman, Mariana; Adams, Emily; Cuevas, Luís E.

doi:10.1371/journal.pntd.0008535

Cited by 6 publications

(7 citation statements)

References 44 publications

(53 reference statements)

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“…Dengue virus (DENV), a mosquito borne flavivirus has been considered a worldwide health threat since up to 350 million individuals live in high-risk transmission areas. The rate of Dengue infection has been estimated to be more than 390 million cases annually in tropical and subtropical countries, of which 96 million manifest clinical pathologies [ 1 , 2 ]. Besides the health problem, DENV is a global economic burden [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Pre-vaccination frequency of circulatory Tfh is associated with robust immune response to TV003 dengue vaccine

Izmirly¹,

Pelletier²,

Connors³

et al. 2022

PLoS Pathog

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It has been estimated that more than 390 million people are infected with Dengue virus every year; around 96 millions of these infections result in clinical pathologies. To date, there is only one licensed viral vector-based Dengue virus vaccine CYD-TDV approved for use in dengue endemic areas. While initially approved for administration independent of serostatus, the current guidance only recommends the use of this vaccine for seropositive individuals. Therefore, there is a critical need for investigating the influence of Dengue virus serostatus and immunological mechanisms that influence vaccine outcome. Here, we provide comprehensive evaluation of sero-status and host immune factors that correlate with robust immune responses to a Dengue virus vector based tetravalent vaccine (TV003) in a Phase II clinical cohort of human participants. We observed that sero-positive individuals demonstrate a much stronger immune response to the TV003 vaccine. Our multi-layered immune profiling revealed that sero-positive subjects have increased baseline/pre-vaccination frequencies of circulating T follicular helper (cTfh) cells and the Tfh related chemokine CXCL13/BLC. Importantly, this baseline/pre-vaccination cTfh profile correlated with the vaccinees’ ability to launch neutralizing antibody response against all four sero-types of Dengue virus, an important endpoint for Dengue vaccine clinical trials. Overall, we provide novel insights into the favorable cTfh related immune status that persists in Dengue virus sero-positive individuals that correlate with their ability to mount robust vaccine specific immune responses. Such detailed interrogation of cTfh cell biology in the context of clinical vaccinology will help uncover mechanisms and targets for favorable immuno-modulatory agents.

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Section: Introductionmentioning

confidence: 99%

Pre-vaccination frequency of circulatory Tfh is associated with robust immune response to TV003 dengue vaccine

Izmirly¹,

Pelletier²,

Connors³

et al. 2022

PLoS Pathog

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“…In Central American countries, such as Guatemala and Barbados, dengue is considered endemic and has burdened health systems [ 85 ]. In Guatemala, the largest dengue outbreak occurred in 2010, with serotype DENV-2 alone resulting in the notification of 1080 cases [ 86 ]. In Barbados, 3994 cases were already reported between 2008 and 2016, and different serotypes circulated during this period, with an emphasis on DENV-1 and DENV-2 [ 87 ].…”

Section: Dengue In the Americasmentioning

confidence: 99%

Dengue as a Disease Threatening Global Health: A Narrative Review Focusing on Latin America and Brazil

et al. 2023

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Arboviruses constitute the largest known group of viruses. These viruses are the etiological agents of pathologies known as arboviruses, with dengue being one of the most prevalent. Dengue has resulted in important socioeconomic burdens placed on different countries around the world, including those in Latin America, especially Brazil. Thus, this work intends to carry out a narrative-based review of the literature, conducted using a study of the secondary data developed through a survey of scientific literature databases, and to present the situation of dengue, particularly its distribution in these localities. Our findings from the literature demonstrate the difficulties that managers face in controlling the spread of and planning a response against dengue, pointing to the high cost of the disease for public coffers, rendering the resources that are already limited even scarcer. This can be associated with the different factors that affect the spread of the disease, including ecological, environmental, and social factors. Thus, in order to combat the disease, it is expected that targeted and properly coordinated public policies need to be adopted not only in specific localities, but also globally.

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“…The second outbreak did not occur until 1987 in the rainy season of Southern Guatemala’s Escuintla. Since that time, outbreaks have been occurring more often and at increased incidence rates with the largest dengue outbreak occurring in 2010 [ 16 , 19 ]. Signor et al (2020) studied 17 years of dengue fever surveillance data in Guatemala (2000 to 2016) in order to describe and identify epidemiological trends [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic and environmental factors associated with dengue fever incidence in Guatemala: Rising temperatures increase dengue risk

Salim,

Álvarez,

Chan-Golston

et al. 2024

PLoS ONE

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Dengue fever is a mosquito-borne illness that infects 390 million people annually. Dengue outbreaks in Guatemala have been occurring more often and at increased rates since the first dengue outbreak in Guatemala in the 1970s. This study will examine environmental and socioeconomic factors associated with dengue in Guatemala at the municipality (county) level. Socioeconomic factors included population density, Mayan population, economic activity, and attending school. Environmental factors included average minimum annual temperature and annual precipitation. The relationship between environmental and socioeconomic variables and dengue fever incidence was initially evaluated through univariate zero-inflated negative binomial models, and then again through three zero-inflated multivariate negative binomial regression models. For all three models, elevation was considered a predictor of zero-inflation. In the combined model, there was a positive relationship between minimum temperature, economic activity and dengue fever incidence, and a negative relationship between population density, Mayan population and dengue fever. Predicted rates of dengue fever incidence and adjusted confidence intervals were calculated after increasing minimum yearly temperature by 1°C and 2°C. The three municipalities with the highest minimum yearly temperature (El Estor, Iztapa, and Panzós) and the municipality of Guatemala, all had an increase in the magnitude of the risk of dengue fever incidence following 1°C and 2°C increase in temperature. This research suggests that these socioeconomic and environmental factors are associated with risk of dengue in Guatemala. The predicted rates of dengue fever also highlight the potential effect that climate change in the form of increasing temperature can have on dengue in Guatemala.

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Epidemiology of dengue fever in Guatemala

Cited by 6 publications

References 44 publications

Pre-vaccination frequency of circulatory Tfh is associated with robust immune response to TV003 dengue vaccine

Pre-vaccination frequency of circulatory Tfh is associated with robust immune response to TV003 dengue vaccine

Dengue as a Disease Threatening Global Health: A Narrative Review Focusing on Latin America and Brazil

Socioeconomic and environmental factors associated with dengue fever incidence in Guatemala: Rising temperatures increase dengue risk

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