Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis

Shrestha, Dhan Bahadur; Budhathoki, Pravash; Gurung, Bipana; Subedi, Subash; Aryal, Shishir; Basukala, Anisha; Aryal, Barun Babu; Adhikari, Anurag; Poudel, Ayusha; Khoury, Mtanis; Rayamajhee, Binod; Shrestha, Lok Bahadur

doi:10.1186/s13071-022-05409-1

Cited by 13 publications

(4 citation statements)

References 78 publications

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“…Older adolescents and young adults also comprised the majority of the cases in 2016 (21-40; 55%), 2018 (15-29; 65%), and 2019 (21-40; 50%) outbreaks [12][13][14] . A similar result was reported in Sri Lanka in 2018 [15] and Ethiopia in 2017 16 . While studies conducted in different parts of India also noted a predominance of young adults [9], the first major dengue outbreak in Delhi in 1996 mainly affected the 5-12-year-old age group 17 .…”

Section: Resultsupporting

confidence: 87%

A Review on Epidemiology, Clinical Manifestation and Diagnostic Approach of Dengue in Bangladesh Perspective

Naznin,

Hossain,

Iftekhar

et al. 2023

J. Bangladesh Coll. Phys.

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Background: Dengue is an arboviral disease caused by dengue virus; single positive stranded RNA virus of the family Flaviviridae. Symptomatic dengue infection causes a wide range of clinical manifestations; from mild dengue fever (DF) to potentially fatal disease, such as dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Dengue is endemic in Bangladesh with recurrent outbreak and is one of the major public health concerns in current period. Therefore; we conducted a literature review to analyze demography, epidemiology, pathogenesis, clinical feature and diagnosis of dengue virus infection. Methods: According to the PRISMA guidelines, the references were selected from PubMed, Web of Science and Google Scholar database using search strings containing a combination of terms that included ”dengue”, “Bangladesh”, “epidemiology”, “outbreak”,” pathogenesis”, “clinical manifestation”, “demography “and “diagnosis”. Quality of references was evaluated by independent contributors. Results: About 167,700 confirmed dengue cases were reported at 16’september’2023 in Bangladesh. Although dengue is endemic in Bangladesh, the current dengue surge is unusual in terms of seasonality and the early sharp increase in comparison to previous years, where the surge started around –late June. Plasma leakages are the main pathophysiological hallmark that distinguishes DHF from DF. Severe plasma leakage can result in hypovolemic shock. Various factors are thought to impact disease presentation and severity. Virus segregation in cell cultures, nucleic acid demonstration by polymerase chain reaction (PCR), and serological detection of viral antigens (such as NS1) or particular antibodies are the preferred microbiological assays for dengue detection. Currently, no specific drugs and licensed vaccines are available to treat dengue disease in any of its clinical presentations for all age group. Conclusion: Understanding the clinical manifestation of dengue infection, prompt diagnosis, appropriate treatment, active and continuous surveillance of cases and vectors are the essential determinants for dengue prevention, control and reducing fatality rate. J Bangladesh Coll Phys Surg 2023; 41: 69-81

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Section: Resultsupporting

confidence: 87%

A Review on Epidemiology, Clinical Manifestation and Diagnostic Approach of Dengue in Bangladesh Perspective

Naznin,

Hossain,

Iftekhar

et al. 2023

J. Bangladesh Coll. Phys.

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“…The World Health Organization (WHO) revised dengue case classification, where severe dengue cases were reported to contain severe plasma leakage leading to dengue shock syndrome and fluid accumulation with respiratory distress, severe bleeding, and severe organ involvement, including the liver (AST or ALT ≥ 1000) and central nervous system, which may cause impaired consciousness, and other organs including heart, and occasional death may occur [ 29 , 30 ]. In SAARC (South Asian Association for Regional Cooperation) countries, the case fatality has been reported to be 1.9% of dengue cases [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Increasing Dengue Burden and Severe Dengue Risk in Bangladesh: An Overview

Kayesh

Khalil²,

Kohara

et al. 2023

TropicalMed

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Dengue is a prevalent and rapidly spreading mosquito-borne viral disease affecting humans. The geographic range of dengue is expanding, and much like in many other tropical regions of the world, dengue has become a major public health issue in Bangladesh. Until a large epidemic dengue outbreak in 2000, sporadic outbreaks have occurred in Bangladesh since 1964. After 2000, varying intensities of dengue activity were observed each year until 2018. However, in 2019, Bangladesh experienced the largest dengue epidemic in its history, with 101,354 dengue cases and 164 dengue-related deaths. Notably, this outbreak occurred in many regions that were previously considered free of the disease. As of 10 December 2022, a total of 60,078 dengue cases and 266 dengue-related deaths were reported in Bangladesh, with the 2022 outbreak being the second largest since 2000. There is an increased genetic diversity of the dengue virus (DENV) in Bangladesh and all four DENV serotypes are prevalent and co-circulating, which increases the risk for severe dengue owing to the antibody-dependent enhancement effect. Vector control remains the mainstay of dengue outbreak prevention; however, the vector control programs adopted in Bangladesh seem inadequate, requiring improved vector control strategies. In this review, we provide an overview of the epidemiology of DENV infection and the risks for a severe dengue outbreak in Bangladesh. Additionally, we discuss different dengue vector control strategies, from which the most suitable and effective measures can be applied in the context of Bangladesh for tackling future dengue epidemics.

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“…While a prevalence of NS1 antigenaemia as high as 35% is seen in all age febrile patients in Nigeria 26 , a prevalence as low as 2.2% in the same nation 27 is reported that is compatible with our observation. An NS1 antigen prevalence of 24.1% is shown in a systematic review among dengue suspected cases in Southeast Asia 28 . Overall, the findings suggest that dengue, as an endemic and epidemic-prone arboviral infection, likely plays a varying role as a cause of illness in both place and time.…”

Section: Discussionmentioning

confidence: 96%

Detection of dengue virus infection in children presenting with fever in Hawassa, southern Ethiopia

Shimelis

Mulu

Mengesha

et al. 2023

Sci Rep

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Dengue fever is a mosquito-borne viral infection, with rising incidence globally. Eastern Ethiopia has had dengue fever outbreaks in recent years. However, the extent to which the infection contributes to hospital presentation among children with fever in southern Ethiopia is unknown. We examined 407 stored plasma samples collected to investigate the aetiology of fever in children aged at least 2 months and under 13 years presenting to the outpatient of the largest tertiary hospital in southern Ethiopia. We analyzed samples for dengue virus non-structural 1 antigen using enzyme-linked immunosorbent assay. The median (interquartile range) age of the 407 children examined was 20 (10–48) months, and 166 (40.8%) of the children were females. Of 407 samples analyzed, 9 (2.2%) were positive for dengue virus non-structural 1 antigen, of whom 2 were initially treated with antimalarial drugs despite having negative malaria microscopy, and 1 of the 8 patients had a persistent fever at the seventh day of follow-up time. The presence of active dengue virus infection in the study area highlights the need for studies at the community level as well as the integration of dengue diagnostics into fever-management strategies. Further research to characterize circulating strains is warranted.

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Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis

Cited by 13 publications

References 78 publications

A Review on Epidemiology, Clinical Manifestation and Diagnostic Approach of Dengue in Bangladesh Perspective

A Review on Epidemiology, Clinical Manifestation and Diagnostic Approach of Dengue in Bangladesh Perspective

Increasing Dengue Burden and Severe Dengue Risk in Bangladesh: An Overview

Detection of dengue virus infection in children presenting with fever in Hawassa, southern Ethiopia

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