Epidemiology of epilepsy in Cameroon: A review

Massi, Daniel Gams; Yacouba, Mapoure Njankouo; Jacques, D.; Caroline, K.; Callixte, Kuate Tegueu

doi:10.1016/j.jns.2019.10.1053

Cited by 2 publications

(1 citation statement)

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“…Epilepsy is a chronic brain disorder affecting over 50 million people globally [9]. Cameroon has one of the highest prevalence worldwide [10], and this disease accounts for a significant proportion of the world's disease burden [11]. Anyone can develop epilepsy, as it affects people of all ages, social classes, races, and geographical locations [11,12].…”

Section: Introductionmentioning

confidence: 99%

Natural products with anticonvulsant potentials from Syzygium aromaticum (Myrtaceae)

Nubed¹,

Taïwé²,

Simons³

et al. 2023

GSC Biol. Pharm. Sci.

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Chemical investigation of the methanol crude extract of dried flower buds of Syzygium aromaticum (Myrtaceae) resulted in the isolation of seven known compounds; oleanolic acid (1), lignoceric acid (2), β-sitosterol (3), heneicosanoic acid (4), 5-hydroxy-7-methoxy-2-methylchromone (5), 5-hydroxy-7-methoxy-2,8-dimethylchromone (6) and vanillin (7). Their structures were elucidated using one-dimensional NMR spectroscopy and comparison with literature data. The crude extract, and compounds 1-6, revealed significant anticonvulsant activities against seizures induced by picrotoxin, pentylenetetrazole and bicuculline, respectively in mice. Compound 3 produced 100% protection, compound 2, and 5; on the other hand, each offered 83.33%, while the lowest protection came from compounds 1, 4, and 6 (16.66 – 50 00 %). This is the first report on the anticonvulsant activity of these isolated compounds, and the first report on the isolation of compounds 2, 4, 5, 6, and 7 from Syzygium aromaticum.

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