Epidemiology of erectile dysfunction

Kubin, Maria; Wagner, Gorm; Fugl‐Meyer, Axel R.

doi:10.1038/sj.ijir.3900949

Cited by 308 publications

(256 citation statements)

References 60 publications

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“…This has important implications in an ageing population because the prevalence is highest in the older age groups. 1,3,8,9 This is in contrast with some studies where older age was associated with more bother 24,25 but in agreement with our earlier bother/prevalence of ED analysis. 8 There was no clearly defined time frame for the men to refer to when answering the question that we have used to assess ED status.…”

Section: Discussioncontrasting

confidence: 57%

“…8,9 To make epidemiological data clinically more relevant, it has been suggested to use a definition of ED in which psychological distress, patient bother or concern is incorporated. 1,3 This approach has not yet been used in studies on the incidence of ED. [4][5][6] Therefore, this study aimed to describe the incidence rate of ED in communitydwelling older Dutch men according to three definitions, including one with concern/bother taken into account.…”

Section: Introductionmentioning

confidence: 99%

“…With the introduction of new classes of drugs and new modes of administration of existing drugs public interest in the condition has increased. [1][2][3] Nevertheless, there is still a paucity of incidence data on ED in the general population. Data are restricted to three surveys conducted in the United States, 4,5 Brazil 4-6 and Finland.…”

Section: Introductionmentioning

confidence: 99%

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Incidence rates of erectile dysfunction in the Dutch general population. Effects of definition, clinical relevance and duration of follow-up in the Krimpen Study

et al. 2004

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This study aims to describe the incidence rate of erectile dysfunction (ED) in older men in the Netherlands according to three definitions. The influence of the duration of follow-up on the incidence rate is also explored. In a large community-based follow-up study, 1661 men aged 50-75 y completed the International Continence Society sex questionnaire and a question on sexual activity, at baseline and at a mean of 2.1 and 4.2 y of follow-up. We defined 'ED' as a report of erections with 'reduced rigidity' or worse; 'Significant_ED' as 'severely reduced rigidity' or 'no erections'; and 'Clinically_Relevant_ED' as either 'ED' reported as 'quite a problem' or 'a serious problem', or 'Significant_ED' reported as at least 'a bit of a problem'. Incidence rates of ED status were calculated in those men who completed at least one period of follow-up and were not diagnosed with prostate cancer (n ¼ 1604). For 'ED' the incidence rate (cases per 1000 person-years) is 99 and ranges over the 10-y age groups from 77 (50-59 y) to 205 (70-78 y); for 'Significant_ED' these rates were 33, 21, and 97, respectively and for 'Clinically_Relevant_ED' 28, 25, and 39, respectively. In general, incidence rates should not vary with the duration of follow-up. However, for 'ED' the 4.2 y incidence rate is about 69% of the 2.1 y incidence rate. This study presents incidence rates, for the general population, as well as based on a definition of ED that takes concern/bother into account. 'Clinically_Relevant_ED' has a lower increase in incidence with increasing age than other definitions that do not take concern/bother into account. The phenomenon of lower incidence rates with longer duration of follow-up may account for the differences in reported incidence rates between different studies. The effects of differences related to the duration of follow-up should be taken into consideration in future incidence reports.

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Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

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Incidence rates of erectile dysfunction in the Dutch general population. Effects of definition, clinical relevance and duration of follow-up in the Krimpen Study

et al. 2004

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“…14 In other studies, prevalence rates of erectile dysfunction have ranged from 61% in Belgium, 69% in Italy to about 80% in Japan. [15][16][17][18] The variability in various aspects of previous investigations such as ED definitions, questionnaire used, study design, age distribution, study population and sample size make a comparison of ED prevalence rates difficult. Quantitative data on the effect of different definitions of ED on the prevalence are lacking, because precise information on the used definition and questionnaire is often absent.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of erectile dysfunction among middle-aged men in a metropolitan area in Germany

et al. 2006

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The comparison of results of previous studies on the prevalence of erectile dysfunction is hampered due to differences in study design and research instruments including definitions used. The aim of the study was to determine the prevalence of erectile dysfunction/erectile disorder (ED) using different definitions.An epidemiological cross-sectional study was conducted between May and November 2002 in Berlin, Germany. A total of 6000 men between 40 and 79 years of age were randomly selected by the Berlin Office of Vital Statistics and were sent a questionnaire by mail. The prevalence of ED was determined using five different methods. A total of 1915 questionnaires were eligible for analysis. The five different definitions yielded age-adjusted ED prevalence rates between 18 and 48%. Age was strongly correlated with all five definitions (Po0.001). These results indicate the need for standardized criteria when conducting future studies on ED and may aid in designing public health and clinical management strategies.

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“…6,7 The incidence of ED has increased due to the modern lifestyle associated with limited physical activity and high-calorie intake. 8 ED is prevalent in patients with cardiovascular comorbidities, diabetes and elevated fasting glucose levels, and is reportedly associated with future coronary risk.…”

Section: Introductionmentioning

confidence: 99%

Effects of Ginkgo biloba extracts with mirodenafil on the relaxation of corpus cavernosal smooth muscle and the potassium channel activity of corporal smooth muscle cells

Kim¹,

Han²,

Lim³

et al. 2011

Asian J Androl

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In this study, we investigated the effects of a combination of Ginkgo biloba extracts (GBE) and phosphodiesterase type 5 (PDE-5) inhibitors on the muscular tone of the corpus cavernosum and potassium channel activity of corporal smooth muscle cells. Strips of corpus cavernosum from male New Zealand white rabbits were mounted in organ baths for isometric tension studies. After contraction with 1310 25 mol l 21 norepinephrine, GBE (0.01-1 mg ml 21 ) and mirodenafil (0.01-100 nmol l 21 ) were added together into the organ bath. In electrophysiological studies, whole-cell currents were recorded by the conventional patch-clamp technique in cultured smooth muscle cells of the human corpus cavernosum. The corpus cavernosum was relaxed in response to GBE in a dose-dependent manner (from 0.64%68.35% at 0.01 mg ml 21 to 52.28%611.42% at 1 mg ml 21 ). After pre-treatment with 0.03 mg ml 21 of GBE, the relaxant effects of mirodenafil were increased at all concentrations. After tetraethylammonium (TEA) (1 mmol l 21 ) administration, the increased effects were inhibited (P,0.01). Extracellular administration of GBE increased the whole-cell K 1 outward currents in a dose-dependent fashion. The increase of the outward current was inhibited by 1 mmol l 21 TEA. These results suggest that GBE could increase the relaxant potency of mirodenafil even at a minimally effective dose. The K 1 flow through potassium channels might be one of the mechanisms involved in this synergistic relaxation.

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Epidemiology of erectile dysfunction

Cited by 308 publications

References 60 publications

Incidence rates of erectile dysfunction in the Dutch general population. Effects of definition, clinical relevance and duration of follow-up in the Krimpen Study

Incidence rates of erectile dysfunction in the Dutch general population. Effects of definition, clinical relevance and duration of follow-up in the Krimpen Study

Prevalence of erectile dysfunction among middle-aged men in a metropolitan area in Germany

Effects of Ginkgo biloba extracts with mirodenafil on the relaxation of corpus cavernosal smooth muscle and the potassium channel activity of corporal smooth muscle cells

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