Epidemiology of Erectile Dysfunction: the Role of Medical Comorbidities and Lifestyle Factors

Rosen, Raymond C.; Wing, Rena R.; Schneider, Stephen H.; Gendrano, Noel

doi:10.1016/j.ucl.2005.08.004

Cited by 101 publications

(86 citation statements)

References 45 publications

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“…It is interesting to note that previous interventional studies have already shown that physical activity is beneficial in reducing rates of ED in nondiabetic men. 16,[33][34][35] The results of our study should be interpreted in the context of several possible limitations. Its crosssectional nature does not allow us to make inference about cause and effect.…”

Section: Discussionmentioning

confidence: 88%

Determinants of erectile dysfunction in type 2 diabetes

et al. 2010

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This study was designed to evaluate the prevalence and correlates of ED in a population of diabetic men. Consecutive patients with type 2 diabetes were recruited among outpatients regularly attending Diabetes Clinics. Inclusion criteria for the initial selection of patients were a diagnosis of type 2 diabetes for at least 6 months but less than 10 years, age 35-70 years, body mass index (BMI) of 24 or higher, HbA1c of 6.5% or higher: a total of 555 (90.8%) of the 611 men were analyzed in this study. ED was assessed by the IIEF-5 instrument. Approximately, 6 in 10 men in our sample of diabetic men had varying degrees of erectile dysfunction: mild 9%, mild to moderate 11.2%, moderate 16.9% and severe 22.9%. The prevalence of severe ED increased with age. Higher hemoglobin A1c (HbA1c) levels were associated with ED; similarly, the presence of metabolic syndrome, hypertension, atherogenic dyslipidemia (low levels of HDL-cholesterol and high levels of triglycerides) and depression was associated with ED. Physical activity was protective of ED; men with higher levels of physical activity were 10% less likely to have ED as compared with those with the lowest level. In conclusion, among subjects with type 2 diabetes glycemic control and other metabolic covariates were associated with ED risk, whereas higher level of physical activity was protective. These results encourage the implementation of current medical guidelines that place intensive lifestyle changes as the first step of the management of type 2 diabetes.

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Section: Discussionmentioning

confidence: 88%

Determinants of erectile dysfunction in type 2 diabetes

et al. 2010

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“…1,2 It is thought to be mainly due to a combination of vascular and neurogenic changes 3 and is strongly associated with other risk factors of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of nitric oxide, lipoprotein(a), and malondialdehyde levels in the peripheral venous and cavernous blood of diabetics with erectile dysfunction

et al. 2006

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Diabetes mellitus (DM) is the single most common cause of erectile dysfunction (ED) seen in clinical practice. Evaluation of penile arterial insufficiency in diabetic patients currently entails expensive and invasive testing. We assessed the diagnostic value of certain peripheral and cavernous blood markers as predictors of penile arterial insufficiency in diabetic men with ED. This study was conducted on a total of 51 subjects in three groups: 26 impotent diabetics, 15 psychogenic impotent men and 10 normal age matched control males. All subjects underwent standard ED evaluation including estimation of postprandial blood sugar and serum lipid profile. Peripheral venous levels of nitric oxide (NO), lipoprotein(a) (LP(a)), malondialdehyde (MDA) and glycosylated hemoglobin (HbA1c) were obtained in all subjects. Patients in the two impotent groups underwent additional measurement of NO, LP(a) and MDA levels in cavernous blood. They also underwent intracavernosal injection (ICI) of a trimix (papaverine, prostaglandin E1 and phentolamine mixture) and pharmaco-penile duplex ultrasonography (PPDU). Compared to patients in the psychogenic group, diabetic men had significantly lower erectile response to ICI (Po0.001), lower peak systolic velocity (PSV) (Po0.001), and smaller increase in cavernosal artery diameter (CAD) (Po0.001). Peripheral and cavernous levels of both LP(a) and MDA were higher in the diabetic group as compared to the psychogenic ED group (Po0.001), while the values of peripheral venous and cavernous NO were lower (Po0.001) in the diabetic men. Comparison of biochemical marker assays with the PPDU results showed a significant negative correlation between both venous and cavernous LP(a) and MDA levels on the one hand, and PSV, and the percentage of CAD increase on the other. At the same time, peripheral and cavernous NO levels had a significant positive correlation with the same parameters. Lipoprotein(a), MDA and NO levels were better predictors of low PSV than HbA1c, cholesterol or triglyceride levels. The finding of high levels of LP(a) and MDA with low levels of NO in the peripheral and cavernous venous blood of diabetic men with ED correlates strongly with severity of ED as measured by PPDU. This provides a rationale for further studies of biochemical markers as a surrogate for traditional invasive testing in the diagnosis of penile arterial insufficiency.

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“…They found that a sustained virological response was associated with an improvement in HRQL and sexual health. Previous studies in men without HCV infection demonstrated that SD was associated with worse HRQL and that HRQL improved in men who were treated for erectile dysfunction 36,37 . Danoff et al 4 .…”

Section: Rev Soc Bras Med Trop 47(5):564-572 Sep-oct 2014mentioning

confidence: 95%

“…Despite this time difference, our study confi rmed that current IFN-α use was associated with SD. Depression and anxiety disorders are commonly associated with SD 36,[38][39][40] . The results of the current study revealed that depressive symptoms were associated with SD and DSL in CHC patients.…”

Section: Rev Soc Bras Med Trop 47(5):564-572 Sep-oct 2014mentioning

confidence: 99%

Sexual dysfunction and dissatisfaction in chronic hepatitis C patients

Fábregas

Moura

Ávila

et al. 2014

Rev. Soc. Bras. Med. Trop.

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564www.scielo.br/rsbmt I www.rsbmt.org.br Revista da Sociedade Brasileira de Medicina Tropical 47(5):564-572, Sep-Oct, 2014http://dx.doi. org/10.1590/0037-8682-0147-2014 Major Article ABSTRACT Introduction: The prevalence of sexual dysfunction (SD) and dissatisfaction with sexual life (DSL) in patients with chronic hepatitis C virus infection (CHC) was jointly investigated via a thorough psychopathological analysis, which included dimensions such as fatigue, impulsiveness, psychiatric comorbidity, health-related quality of life (HRQL) and sociodemographic and clinical characteristics. Methods: Male and female CHC patients from an outpatient referral center were assessed using the Brief Fatigue Inventory, the Barrat Impulsiveness Scale, the Beck Depression Inventory (BDI), the Hospital Anxiety and Depression Scale, the Hamilton Anxiety Scale (HAM-A), and the World Health Organization Quality of Life Scale-Brief Version (WHOQOL-BREF). Structured psychiatric interviews were performed according to the Mini-International Neuropsychiatric Interview. SD was assessed based on specifi c items in the BDI (item 21) and the HAM-A (item 12). DSL was assessed based on a specifi c question in the WHOQOL-BREF (item 21). Multivariate analysis was performed according to an ordinal linear regression model in which SD and DSL were considered as outcome variables. Results: SD was reported by 60 (57.1%) of the patients according to the results of the BDI and by 54 (51.4%) of the patients according to the results of the HAM-A. SD was associated with older age, female gender, viral genotype 2 or 3, interferon-α use, impulsiveness, depressive symptoms, antidepressant and benzodiazepine use, and lower HRQL. DSL was reported by 34 (32.4%) of the patients and was associated with depressive symptoms, anxiety symptoms, antidepressant use, and lower HRQL. Conclusions: The prevalence of SD and DSL in CHC patients was high and was associated with factors, such as depressive symptoms and antidepressant use. Screening and managing these conditions represent signifi cant steps toward improving medical assistance and the HRQL of CHC patients.

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Epidemiology of Erectile Dysfunction: the Role of Medical Comorbidities and Lifestyle Factors

Cited by 101 publications

References 45 publications

Determinants of erectile dysfunction in type 2 diabetes

Determinants of erectile dysfunction in type 2 diabetes

Diagnostic value of nitric oxide, lipoprotein(a), and malondialdehyde levels in the peripheral venous and cavernous blood of diabetics with erectile dysfunction

Sexual dysfunction and dissatisfaction in chronic hepatitis C patients

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