Epidemiology of familial multiple sclerosis: A population-based study in Tehran during 1999–2018

Salehi, Zahra; Almasi‐Hashiani, Amir; Sahraian, Mohammad Ali; Eskandarieh, Sharareh

doi:10.1016/j.msard.2020.102178

Cited by 13 publications

(15 citation statements)

References 28 publications

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“…While, one study reported parent-child relationship as the prevalent kinship [28]. In this context, the probability of the transmission of disease from mother to child is more than father to child [13,8,58]. Amongst the siblings, sister-sister, sister-brother, and brother-brother relation are, respectively, more prevalent [29,34].…”

Section: Discussionmentioning

confidence: 99%

“…Amongst the siblings, sister-sister, sister-brother, and brother-brother relation are, respectively, more prevalent [29,34]. Evidently, after rst-degree relatives, third-degree relatives have more chance for the development of MS [13,18,34].…”

Section: Discussionmentioning

confidence: 99%

“…Hence, it seems that the worldwide frequency of FMS is steady-state over time. Nonetheless, some studies in middle-east reported the increasing [13,24] or decreasing [16] prevalence of FMS over time, highlighting the existence of substantial difference in terms of genetic and environmental factors between different populations even in a same geographical area. Moreover, the overwhelming majority of the studies have been performed in a cross-sectional setting; while, su cient long follow-up period is needed to evaluate the development of the disease in new members of the relatives, primarily distant relatives that would not have been found in short-term periods.…”

Section: Discussionmentioning

confidence: 99%

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The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis

Ehtesham

Rafie

Mosallaei

2021

Preprint

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Background: Considering that familial multiple sclerosis (FMS) can reveal the extent to which genetic and environmental factors each involve in the etiopathogenesis of the disease, we performed an updated meta-analysis of the worldwide prevalence of FMS by addition of recent publications. Methods: A search in PubMed, Scopus, the ISI Web of Science, and Google Scholar up to 20 December 2020 was done. The inclusion criteria were based on the CoCoPop approach (condition, context, and population). The qualified studies entered the process of the meta-analysis by using comprehensive meta-analysis ver. 2 software.Results: The pooled prevalence of MS in relatives of 16179 FMS cases was estimated to be 11.8% (95% CI: 10.7-13) based on a random-effects model. The pooled mean age of disease onset in adult probands was calculated to be 28.7 years (95% CI: 27.2± 30.2). In 13 studies that reported the data of FMS in pediatrics (n=6636) and adults (n=877), the FMS prevalence was 10.8% (95% CI: 8.1-14.2) and 15.5% (95% CI: 13.8-17.4), respectively. Considering the data of 9 studies, the prevalence of FMS in males (n=5243) and females (n=11503) patients was calculated to be 13.7% (95% CI: 10.1-18.2) and 15.4% (95% CI: 10.3-22.4), respectively. The odds ratio of male/female in FMS cases was not statistically significant (OR= 0.9; 95% CI: 0.6-1.2, P=0.55). Subgroup analysis demonstrated a significant difference in the prevalence of FMS between the geographical areas (P= 0.007). The meta-regression model for FMS prevalence was significantly lower in terms of higher latitude (P< 0.001) and increased MS prevalence (P< 0.001). In contrast, meta-regression based on prevalence day was not statistically significant (P=0.29).Conclusions: The prevalence of FMS is more in the pediatric group than that of adults, is distinct between geographical areas, and diminishes with the increment of MS prevalence and latitude. Also, the symptoms initiate relatively at lower ages in FMS cases. By contrast with multifactorial diseases, our analysis unveiled that the prevalence of FMS was not more prevalent in men than women and the risk of MS development in relatives was not more when the affected proband was male.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis

Ehtesham

Rafie

Mosallaei

2021

Preprint

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“…The general population is approximately at risk of MS of 0.2 %. The first-grade relative has an estimated 3% -5%, and 15-25% higher relative MS risk than the background population [17][18][19]. Among families, the risk of recurrence is increasing with the proportion of gender sharing.…”

Section: Genetic Risk In Multiple Sclerosismentioning

confidence: 99%

An Overview of Genome-Wide Association Studies in Multiple Sclerosis

Algothmi

2021

JPRI

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The common neurodegenerative disorder of the central nervous system is multiple sclerosis (MS). It progresses with autoimmune inflammation and demyelination. Molecular basis study of MS pathogenesis is a significant element of field research, leading to new prevention and treatment strategies by defining the genetic association, epigenetic, and environmental risks factor of MS that could provide a predictive method for estimating human predisposition to MS. From a genetic perspective, MS is a complex disorder due to the combination of genetic and non-genetic factors. The main histocompatibility complex (MHC) is the only universal genetic site associated with MS, and it has been approved for many years. The most common risk for MS in most populations is human leukocyte antigen (HLA) at 6p21. Before the advent of genome-wide association studies (GWASs) encouraging finding new susceptibility loci, other genetic factors in the MS remained uncommon. In this literature review, we summarized details, including references, abstracts, and full text of journal articles. These details were selected and obtained from virtual databases such as Medline and PubMed. Using the keywords and health descriptors in MS, GWAS, IL7R and HLA genes for published data from 2007 until 2019.So, the purpose of this research was to perform an analysis of recent progress in identifying genetic factors and gene polymorphism that affect the risk of MS and how these results explain the disease pathogenesis.

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“…These regions have low-to-moderate incidences of MS, with rates lower than Southern Europe but considerably higher than Sub-Saharan Africa. Iran has always had the highest MS incidence in the region, rising from 51.9 to 2010 to 148.06 per 100,000 population in 2017, likely due to genetic factors linked to the Iranian population’s multiple ethnic backgrounds [ 14 – 16 ]. Early diagnosis, particularly with the advent of magnetic resonance imaging in the 1980 s and the new McDonald diagnostic criteria, may be part of the explanation for the rapid increase in prevalence rates in the Middle East region [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Multiple sclerosis projection in Tehran, Iran using Bayesian structural time series

et al. 2021

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Background The prevalence of Multiple Sclerosis (MS) has been increasing worldwide and the highest prevalence ratio among Asian countries was reported in Iran. This study aims to estimate the increase in MS occurrence during more than three decades in Tehran and forecast the future condition of the disease using time series approaches for the next ten years. Methods The cross-sectional study was conducted from 1999 to 2019 based on records of MS cases from Iranian MS Society (IMSS) registry system. The prevalence was estimated using population data presented by the Statistical Centre of Iran. Through Bayesian Structural Time Series (BSTS) model, we want to predict the prevalence of familial and sporadic MS in the next ten years. . Results Among 22,421 cases with MS, 16,831 (75.1 %) were female and 5589 (24.9 %) were male. Female to male ratio was 3.0:1 and the number of familial MS cases were 2982 (13.3 %) of subjects. Female gender was less responsible for higher rate of MS in familial definition (beta = 0.020) in comparison to sporadic cases (beta = 0.034). Forecasting by BSTS revealed an increase in MS prevalence for the next ten years so that the prevalence rate for total, familial and sporadic MS respectively begins with 189.50 (183.94-195.14), 25.69 (24.97–26.45) and 163.74(159.06-168.57) in 2020 and ends with 220.84 (171.48-266.92), 30.79 (24.16–37.15), and 189.33(146.97-230.19) in 2029. Conclusions According to the findings, MS prevalence increased during three decades and it will increase over the next ten years. Tehran province is one of the regions with highest MS prevalence in Asia. The results of present study indicated that females are at higher risk for MS than males in both sporadic and familial MS.

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Epidemiology of familial multiple sclerosis: A population-based study in Tehran during 1999–2018

Cited by 13 publications

References 28 publications

The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis

The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis

An Overview of Genome-Wide Association Studies in Multiple Sclerosis

Multiple sclerosis projection in Tehran, Iran using Bayesian structural time series

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