Epidemiology of fat replacement of the right ventricular myocardium determined by multislice computed tomography using a logistic regression model

Imada, Megumi; Funabashi, Nobusada; Asano, Masahisa; Uehara, Masae; Hori, Yasuhiko; Ueda, Marehiko; Komuro, Issei

doi:10.1016/j.ijcard.2006.07.174

Cited by 31 publications

(19 citation statements)

References 17 publications

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“…An interesting finding was that an increase in the presence of myocardial fatty replacement was not significantly related to the patients' BMI. This differs from previous reports by Maskimovic and Imada which showed that obesity is significantly more common in cases of fatty replacement of RV [14,22].…”

Section: Discussioncontrasting

confidence: 99%

Focal macroscopic fat deposition within the right ventricular wall in asymptomatic patients undergoing screening EBCT coronary calcium scoring examinations

Kirsch

Williamson

Glockner

2007

Int J Cardiovasc Imaging

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Section: Discussioncontrasting

confidence: 99%

Focal macroscopic fat deposition within the right ventricular wall in asymptomatic patients undergoing screening EBCT coronary calcium scoring examinations

Kirsch

Williamson

Glockner

2007

Int J Cardiovasc Imaging

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“…This data is similar to the results reported by Imada et al [6], who so far have been the only ones who have analysed changes in coronary arteries in patients with fat infiltration of the anterior wall of the RV. The authors evaluated 49 patients who were diagnosed in ECG-gated MSCT examinations -76% of them had calcified and 24% had non-calcified atherosclerotic plaques in the coronary arteries.…”

Section: Discussionsupporting

confidence: 92%

Fatty foci within the heart and the accompanying changes in the coronary arteries diagnosed in electrocardiogram-gated multislice computed tomography of the heart

et al. 2014

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“…28 A study of 49 subjects using enhanced CT imaging showed that obesity was a signifi cant risk factor for fat replacement of the RV myocardium in healthy individuals. 29 Animal models of cardiac-specifi c steatosis show an increase in cardiac mass, ventricular dilation, and progression to heart failure in the absence of systemic obesity or its sequelae, suggesting a direct cardiotoxic effect of fat. 30 Human studies have shown that myocardial lipid content increases with BMI 31 and contributes to oxidative stress and cardiac myocyte apoptosis.…”

Section: Acknowledgmentsmentioning

confidence: 99%

Obesity and Right Ventricular Structure and Function

Chahal

McClelland

Tandri

et al. 2012

Chest

125

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T he prevalence of obesity has doubled in adults and more than tripled in children in the United States in the past 25 years and increases the risk of heart failure and death. 1,2 Obesity is associated with increases in total blood volume, left ventricular (LV) mass, LV stroke volume, and cardiac output without changes in LV ejection fraction (LVEF). 3-7 Also seen is the direct infi ltration or metaplasia of fat in the heart, termed the "cardiomyopathy of obesity." [8][9][10] Right ventricular (RV) morphology and function are important determinants of outcome in cardiopulmonary conditions, such as COPD, congestive heart failure, and pulmonary arterial hypertension. [11][12][13] Although obesity clearly affects the LV, few studies have examined the impact of obesity on the RV. Studies have shown RV systolic and diastolic dysfunction in overweight and obese individuals. 14,15 However, these were small studies of selected populations without signifi cant ethnic diversity using transthoracic echocardiography, which has limitations in the evaluation of the RV particularly in obese individuals. MRI offers precise and reproducible assessment of the RV and is considered the standard of reference for determination of RV morphology. 16 The aim of this study was to assess the relationship between obesity and RV structure and function assessed with MRI in a multiethnic population free of clinical cardiovascular disease. Background:The relationship between obesity and right ventricular (RV) morphology is not well studied. We aimed to determine the association between obesity and RV structure and function in a large multiethnic population-based cohort. Results: The study sample included 4,127 participants. After adjustment for demographics, height, education, and cardiovascular risk factors, overweight and obese participants had greater RV mass (6% and 9% greater, respectively), larger RV end-diastolic volume (8% and 18% greater, respectively), larger RV stroke volume (7% and 16% greater, respectively), and lower RV ejection fraction ( Ն 1% lower) than lean participants (all P , .001). These fi ndings persisted after adjusting for the respective left ventricular (LV) parameters. Conclusions: Overweight and obesity were independently associated with differences in RV morphology even after adjustment for the respective LV measure. This association could be explained by increased RV afterload, increased blood volume, hormonal effects, or direct obesity-related myocardial effects.CHEST 2012; 141(2):388-395

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Epidemiology of fat replacement of the right ventricular myocardium determined by multislice computed tomography using a logistic regression model

Cited by 31 publications

References 17 publications

Focal macroscopic fat deposition within the right ventricular wall in asymptomatic patients undergoing screening EBCT coronary calcium scoring examinations

Focal macroscopic fat deposition within the right ventricular wall in asymptomatic patients undergoing screening EBCT coronary calcium scoring examinations

Fatty foci within the heart and the accompanying changes in the coronary arteries diagnosed in electrocardiogram-gated multislice computed tomography of the heart

Obesity and Right Ventricular Structure and Function

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