Epidemiology of Fatty Liver in a Hospital-based Study in Taiwan

Lai, Shih‐Wei; Tan, Chee-Keong; Ng, Kim-Choy

doi:10.1097/00007611-200211000-00011

Cited by 19 publications

(15 citation statements)

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“…[12][13][14] Worldwide, the prevalence of NAFLD in the general population ranges from 9%-37%. [15][16][17][18][19][20][21][22] In the United States, recent estimates suggest that NAFLD affects 30% of the general population and as high as 90% of the morbidly obese. 23 The histopathologic entity known as NASH has been estimated to affect 5%-7% of the general population and as many as 34%-40% of patients who have elevated liver enzymes in the setting of negative serologic markers for liver disease.…”

Section: Epidemiology Of Nafldmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma: A Weighty Connection

2010

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Hepatocellular carcinoma (HCC) is a common and deadly malignancy that is increasing in incidence in developed countries. The emergence of hepatitis C virus (HCV) accounts for about half of this increase in HCC, although the etiology of HCC in 15%-50% of new HCC cases remains unclear. The most common form of chronic liver disease in developed countries is nonalcoholic fatty liver disease (NAFLD), which encompasses a broad spectrum of histopathology. The prevalence of NAFLD, including the more aggressive nonalcoholic steatohepatitis (NASH), is increasing with the growing epidemics of diabetes and obesity. NASH can progress to cirrhosis and its related complications. Growing evidence suggests that NASH accounts for a large proportion of idiopathic or cryptogenic cirrhosis, which is associated with the typical risk factors for NASH. HCC is a rare, although important complication of NAFLD. Diabetes and obesity have been established as independent risk factors for the development of HCC. New evidence also suggests that hepatic iron deposition increases the risk of HCC in NASH-derived cirrhosis. Multiple case reports and case reviews of HCC in the setting of NASH support the associations of diabetes and obesity with the risk of HCC, as well as suggest age and advanced fibrosis as significant risks. Insulin resistance and its subsequent inflammatory cascade that is associated with the development of NASH appear to play a significant role in the carcinogenesis of HCC. The complications of NASH, including cirrhosis and HCC, are expected to increase with the growing epidemic of diabetes and obesity.

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Section: Epidemiology Of Nafldmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma: A Weighty Connection

2010

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“…NASH and NAFLD are no longer considered strictly western diseases since they have been identified in urban areas around the world. Epidemiological studies in Asian countries found that 9.3%-36.9% of patients had fatty liver on ultrasound examination [6][7][8] . Metabolic syndrome, which is defined by the guideline of the Adult Treatment Panel Ⅲ (ATPⅢ) is prevalent in NAFLD and even more so in NASH [9] .…”

Section: Introductionmentioning

confidence: 99%

Visceral fat and insulin resistance as predictors of non-alcoholic steatohepatitis

Sobhonslidsuk

Jongjirasiri²,

Thakkinstian³

et al. 2007

WJG

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A m m a r i n T h a k k i n s t i a n , Clinical Epidermiology unit, Ramathibodi Hospital, Mahidol University, Thailand Naruemon Wisedopas, Abstract AIM: To examine whether visceral fat is associated with non-alcoholic steatohepatitis (NASH), to assess for parameters associated with visceral adiposity and to investigate for factors associated with fibrotic severity in NASH. METHODS:Thirty NASH and 30 control subjects u n d e r w e n t b i o c h e m i c a l t e s t s , a n t h r o p o m e t r i c assessment, bioelectrical impedance, dual energy X-ray absorptiometry and abdominal fat study by CT scan. Liver biopsies were graded according to the Brunt criteria. RESULTS:

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“…Recent studies in Taiwan and Japan on patients attending medical examination in local hospitals found that 9.3-36.9% of patients had fatty liver on ultrasound examination. 2,21 These studies were however limited by the use of the relatively inaccurate diagnostic method and the failure to define the histological severity of the disease. 22,23 In our hospital, liver biopsy was performed in all patients who have deranged liver function tests or abnormal imaging results of unknown aetiology and who consented to the procedure.…”

Section: Introductionmentioning

confidence: 99%

Clinical and histological features of non‐alcoholic fatty liver disease in Hong Kong Chinese

Wong¹,

Chan²,

Hui³

et al. 2004

Aliment Pharmacol Ther

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Summary Background : Non‐alcoholic fatty liver disease is prevalent in affluent countries and is a cause of cirrhosis and possibly hepatocellular carcinoma. Aim : To examine the clinical and histological features of biopsy‐proven non‐alcoholic fatty liver disease and investigate the predictors of severe histological disease in Chinese patients. Methods : Electronic records of all patients (n = 247) who underwent liver biopsy between 1996 and 2003 in our hospital were retrieved. Patients who had histological features of non‐alcoholic fatty liver disease were identified. The demographic, clinical, laboratory and histological (Brunt's criteria) parameters of these patients were analysed. Results : Forty‐two patients had histology‐proven non‐alcoholic fatty liver disease. The median age was 47 years (range 23–69). All except one patient had features of metabolic syndrome. The median alanine aminotransferase was 93 (range 24–270) IU/L. Thirty‐six (85.7%) patients had steatohepatitis and 11 (26.1%) also had fibrosis. Only one patient had stage 3 fibrosis. The presence of diabetes mellitus predicted higher grade steatohepatitis and fibrosis (P = 0.019) whereas alanine aminotransferase level had no correlation with histological severity of steatohepatitis. After a median follow‐up of 42 months, no patient developed hepatic decompensation. Conclusions : Most Chinese patients with non‐alcoholic fatty liver disease had features of the metabolic syndrome. Histological activity was generally mild. Diabetes mellitus was the most important predictor of severe histological disease.

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Epidemiology of Fatty Liver in a Hospital-based Study in Taiwan

Cited by 19 publications

References 0 publications

Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma: A Weighty Connection

Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma: A Weighty Connection

Visceral fat and insulin resistance as predictors of non-alcoholic steatohepatitis

Clinical and histological features of non‐alcoholic fatty liver disease in Hong Kong Chinese

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