Epidemiology of fractures in patients with haemophilia

Caviglia, Horacio; Landro, María Eulalia; Galatro, Gustavo; Candela, M.; Neme, Daniela

doi:10.1016/j.injury.2015.06.034

Cited by 14 publications

(18 citation statements)

References 9 publications

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“…37 However, many studies have shown that time of bone healing after fracture does not differ between patients with and without haemophilia. 38 We observed no complications associated with postoperative bleeding in the present study. The complication rates associated with bleeding in open-wedge HTO using allobone are low in the general population.…”

Section: Radiographic Evaluationsupporting

confidence: 40%

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Clinical and radiologic results after open‐wedge high tibial osteotomy in haemophilic knee arthropathy with varus deformity

et al. 2018

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Section: Radiographic Evaluationsupporting

confidence: 40%

“…There is some concern that bone healing in haemophilia might be delayed . However, many studies have shown that time of bone healing after fracture does not differ between patients with and without haemophilia . Even, Salduz et al reported a case of successful distraction osteogenesis using an external fixator in a haemophilic patient.…”

Section: Discussionmentioning

confidence: 99%

Clinical and radiologic results after open‐wedge high tibial osteotomy in haemophilic knee arthropathy with varus deformity

et al. 2018

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“…However, a person with haemophilic arthropathy should still be considered at risk for fractures around joints that have significant loss of motion and in bones that are osteoporotic. 18 Caviglia et al 21 reported the largest series of 151 fractures in haemophiliacs. They have underlined a changing pattern of fractures, becoming more common in the upper extremity, with occurrence at younger ages but being less frequent overall.…”

Section: Fracturesmentioning

confidence: 99%

“…18 Compartment syndrome is more likely to occur in haemophilic patients, so documenting the neurovascular function is vital. 18,21 However, complications are now less frequent due to the advent of new and more feasible treatments, consequently producing less impairment of the patient’s quality of life. 18,21…”

Section: Fracturesmentioning

confidence: 99%

Musculoskeletal treatment in haemophilia

Atilla

Guney

2019

EFORT Open Reviews

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Haemophilia is a group of coagulation disorders inherited in an X-linked recessive pattern. Nearly three-quarters of all haemorrhages in haemophilia occur in the musculoskeletal system, usually in the large muscles and joints of the lower extremity. While prevention of bleeding with active prophylaxis is the recommended optimal therapy for severe haemophilia, there are many patients suffering from musculoskeletal system complications subsequent to uncontrolled bleeding. Recombinant clotting factor concentrates led to home treatment of acute bleeding episodes as well as allowing for minor and major surgical interventions. Avoiding of further complications by radiosynoviorthesis is the first-line recommendation, and arthroplasty is regarded as the effective salvage procedure for patients presenting with severe disability. Physiotherapy and rehabilitation in haemophilia patients are important to return the normal status of joint motion, to regain the muscle strength, to obtain the optimal functional levels and to improve patients’ quality of life. Cite this article: EFORT Open Rev 2019;4 DOI: 10.1302/2058-5241.4.180068

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“…A recent retrospective study showed a shift in fracture prevalence from the lower to the upper limbs, as the most common skeletal site, during the last decade (63% compared with 24–30% during the period before 2002). The mean age was 32 years showing also a decrease during the last decade (from 35 to 26 years) .…”

Section: Introductionmentioning

confidence: 95%