Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC)

Zhao, Yanfang; Ma, Xueqin; Wang, R.; Yan, Xiao; Li, Z.-S.; Zou, Duowu; He, Jia

doi:10.1111/j.1365-2036.2011.04809.x

Cited by 76 publications

(68 citation statements)

References 38 publications

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“…Our results were in agreement to the previous cross-sectional survey conducted in adult Chinese population (n = 16 078) where BMI, alcohol consumption, and smoking status were comparable across both constipation subtypes. 21 In 2008, Pourhoseingholi et al conducted a cross-sectional study in Tehran province where 40% of FC patients were overweight and 20% were obese, indicating a clear association between obesity and FC; however Zhao et al, in 2011 found a negative correlation between high BMI and FC and few studies reported no significant relationship between BMI and FC. [22][23][24] In 2013, Farzaneh et al evaluated the effects of demographic factors, BMI, alcohol drinking and smoking habits in 153 IBS patients against 163 non-IBS patients at Taleghani Hospital Gastroenterology Clinic at Tehran.…”

Section: Discussionmentioning

confidence: 99%

“…Our results were comparable to a previously reported literature where patients with IBS-C were much more likely to report gastroesophageal reflux disorder. 21,39 In another study, dyspepsia and diabetes were reported as the most common comorbidities in patients with IBS-C and FC, respectively. 37 In addition, 7.15% patients of FC were on antidepressants for management of stress/ anxiety/ depression.…”

Section: Discussionmentioning

confidence: 99%

“…Other symptoms of constipation were comparable between both constipation subtypes. 21 The severity of constipation was assessed by CSS. Patients of both constipation subtypes had a high severity of constipation and about 50% of patients with FC spent >10 minutes in the lavatory per attempt.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of functional constipation and constipation-predominant irritable bowel syndrome in Indian patients with constipation

Rooprai

Bhat

Sainani³

et al. 2017

Int J Basic Clin Pharmacol

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Background: Evaluate prevalence of functional constipation (FC) and irritable bowel syndrome-constipation (IBS-C) in Indian constipated patients and assess their demographic/socio-economic/clinical characteristics.Methods: Patients (≥18 years) who visited their general physician with symptoms of constipation (Rome III criteria for FC or IBS-C as per physician assessment) and willing to participate were enrolled in this prospective, clinical-epidemiological study. Demographic, socioeconomic status, lifestyle and dietary habits, comorbid conditions, treatment history, concomitant medications, stool form (Bristol stool form scale), severity of constipation (constipation scoring system [CSS]), constipation-related symptoms (patient assessment of constipation symptoms [PAC-SYM]) and quality of life (patient assessment of constipation-quality of life questionnaire [PAC-QoL]) were recorded.Results: Out of 925 constipated patients, 75.6% were diagnosed with FC against 24.4% with IBS-C (P < 0.0001). Patients of both subtypes had high average scores of PAC-SYM (FC: 27.1 ± 6; IBS-C: 30.1 ± 4.9) and CSS (FC: 8.4 ± 3.1; IBS-C: 11.2 ± 3), leading to high PAC-QoL score (FC: 38.1 ± 16.8; IBS-C: 42.2 ± 13.6). Hypertension (16%) and diabetes (10%) in patients with FC while acid peptic disorders (21.7%) amongst IBS-C patients were the most common comorbid conditions observed. Laxatives were the most common medication used; osmotic (32.6% versus 40.7%) and bulk laxatives (22.8% versus 37.4%) were the commonest laxatives. However, about 1/5th patients of FC were using home remedies.Conclusions: There was a higher prevalence of FC over IBS-C in Indian constipated patients; both subtypes had high frequency and severity of constipation-related symptoms and poor QoL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prevalence of functional constipation and constipation-predominant irritable bowel syndrome in Indian patients with constipation

Rooprai

Bhat

Sainani³

et al. 2017

Int J Basic Clin Pharmacol

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show abstract

“…[1][2][3] Some authors questioned the partitioning and treated the FC and IBS-C as distinct parts of a continuum, with differences based only on symptom severity. [4][5][6][7][8] Nevertheless, differential responses to treatment seem to suggest that FC and IBS-C may be different disorders. 9 Whether being different points of the same disorders or distinct disorders, it is of great importance in illustrating pathophysiological mechanisms underlying the discrimination between FC and IBS-C.…”

Section: Introductionmentioning

confidence: 99%

White Matter Microstructural Similarity and Diversity of Functional Constipation and Constipation-predominant Irritable Bowel Syndrome

Nan

Zhang

Chen

et al. 2018

J Neurogastroenterol Motil

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Background/AimsThe Rome III criteria separated chronic constipation into functional constipation (FC) and constipation-predominant irritable bowel syndrome (IBS-C), but some researchers questioned the partitioning and treated both as distinct parts of a continuum. The study aims to explore the similarity and diversity of brain white matter between FC and IBS-C. MethodsThe voxel-wise analysis of the diffusion parameters was used to quantify the white matter changes of female brains in 18 FC patients and 20 IBS-C patients compared with a comparison group with 19 healthy controls by tract-based spatial statistics. The correlations between diffusive parameters and clinical symptoms were evaluated using a Pearson's correlation. ResultsIn comparison to healthy controls, FC patients showed a decrease of fractional anisotropy (FA) and an increase of radial diffusivity (RD) in multiple major fibers encompassing the corpus callosum (CC, P = 0.001 at peak), external capsule (P = 0.002 at peak), corona radiata (CR, P = 0.001 at peak), and superior longitudinal fasciculus (SLF, P = 0.002 at peak). In contrast, IBS-C patients showed FA and RD aberrations in the CC (P = 0.048 at peak). Moreover, the direct comparison between FC and IBS-C showed only RD differences in the CR and SLF. In addition, FA and RD in the CC were significantly associated with abdominal pain for all patients, whereas FA in CR (P = 0.016) and SLF (P = 0.040) were significantly associated with the length of time per attempt and incomplete evacuation separately for FC patients. ConclusionThese results may improve our understanding of the pathophysiological mechanisms underlying different types of constipation.

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“…2 On the mainland of China, about 6% of population experience constipation, of which women and the elderly are the largest group. 3 Although non-life-threatening, long-term constipation can cause serious complications, such as diverticulosis of the colon, crissum diseases, and melanosis coli. 4 As Rogers concluded, chronic constipation not only can bring about discomfort but also affects a person's physical and psychological wellbeing, with further consequences of reduced quality of life and high costs for both families and society.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Auriculotherapy for Constipation in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Lei

Duan

et al. 2014

The Journal of Alternative and Complementary Medicine

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Objectives: To assess the clinical evidence of auriculotherapy for constipation treatment and to identify the efficacy of groups using Semen vaccariae or magnetic pellets as taped objects in managing constipation. Methods: Databases were searched, including five English-language databases (the Cochrane Library, PubMed, Embase, CINAHL, and AMED) and four Chinese medical databases. Only randomized controlled trials were included in the review process. Critical appraisal was conducted using the Cochrane risk of bias tool. Results: Seventeen randomized, controlled trials (RCTs) met the inclusion criteria, of which 2 had low risk of bias. The primary outcome measures were the improvement rate and total effective rate. A meta-analysis of 15 RCTs showed a moderate, significant effect of auriculotherapy in managing constipation compared with controls (relative risk [RR], 2.06; 95% confidence interval [CI], 1.52-2.79; p < 0.00001). The 15 RCTs also showed a moderate, significant effect of auriculotherapy in relieving constipation (RR, 1.28; 95% CI, 1.13-1.44; p < 0.0001). For other symptoms associated with constipation, such as abdominal distension or anorexia, results of the meta-analyses showed no statistical significance. Subgroup analysis revealed that use of S. vaccariae and use of magnetic pellets were both statistically favored over the control in relieving constipation. Conclusions: Current evidence illustrated that auriculotherapy, a relatively safe strategy, is probably beneficial in managing constipation. However, most of the eligible RCTs had a high risk of bias, and all were conducted in China. No definitive conclusion can be made because of cultural and geographic differences. Further rigorous RCTs from around the world are warranted to confirm the effect and safety of auriculotherapy for constipation.

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Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC)

Abstract: SUMMARY BackgroundThe epidemiology and effects of functional constipation (FC) on Chinese people remain unclear.

Cited by 76 publications

References 38 publications

Prevalence of functional constipation and constipation-predominant irritable bowel syndrome in Indian patients with constipation

Prevalence of functional constipation and constipation-predominant irritable bowel syndrome in Indian patients with constipation

White Matter Microstructural Similarity and Diversity of Functional Constipation and Constipation-predominant Irritable Bowel Syndrome

Efficacy of Auriculotherapy for Constipation in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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