Epidemiology of Functional Diarrhea and Comparison with Diarrhea-Predominant Irritable Bowel Syndrome: A Population-Based Survey in China

Zhao, Yanfang; Guo, Xiaojing; Zhang, Zhan-Sai; Ma, Xiaoyan; Wang, Rui; Yan, Xiaoyan; He, Jia

doi:10.1371/journal.pone.0043749

Cited by 50 publications

(43 citation statements)

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“…17 Furthermore, we applied the Rome II criteria and RDQ to diagnose FGIDs so that we were able to divide FD and IBS into more specific subtypes in order to avoid confusion of similar diseases, such as diarrhea-predominant IBS and functional diarrhea, constipation-predominant IBS, and functional constipation. 29,30 Overweight and obesity were significantly associated with EDS. Obesity has been proved to be a major risk factor for EDS, while weight loss is associated with its remission.…”

Section: Discussionmentioning

confidence: 95%

Association Between Excessive Daytime Sleepiness and Functional Gastrointestinal Disorders: A Population-based Study in China

Chen

Zhao

et al. 2017

J Neurogastroenterol Motil

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Background/AimsSeveral studies have demonstrated that sleep problems are associated with functional gastrointestinal disorders (FGIDs): irritable bowel syndrome (IBS), functional dyspepsia, etc, but the relationship between excessive daytime sleepiness (EDS) and FGIDs has not been systematically studied in the general population. This study aims to explore the relationship between EDS and specific types of FGIDs and the effect of the number of FGIDs on EDS. MethodsA sample of 3600 individuals (aged 18-80 years) was selected from 5 regions in China using a randomized, stratified, multi-stage sampling method. EDS was measured by the Epworth Sleepiness Scale, while gastroesophageal reflux disease (GERD) and other FGIDs were assessed by Reflux Disease Questionnaire and the Rome II diagnostic criteria, respectively. ResultsThe survey was completed by 2906 individuals (response rate: 80.72%), and 644 individuals (22.16%) had EDS. EDS was significantly associated with ulcer-like dyspepsia (OR, 2.50; 95% CI, 1.08-5.79), diarrhea-predominant IBS (OR, 2.00; 95% CI, 1.09-3.66), alternating IBS (OR, 2.32; 95% CI, 1.30-4.13), functional constipation (OR, 1.68; 95% CI, 1.20-2.35), and GERD (OR, 1.72; 95% CI, 1.08-2.72). Risk of EDS increased along with the increasing numbers of FGIDs: with 1 FGID (OR, 1.72; 95% CI, 1.37-2.15); with 2 FGIDs (OR, 2.43; 95% CI, 1.63-3.62); and with 3 or more FGIDs (OR, 3.26; 95% CI,). ConclusionsFGIDs, such as ulcer-like dyspepsia, diarrhea-predominant IBS, alternating IBS, functional constipation, and GERD, were significantly associated with EDS. Those who suffered from more kinds of FGIDs were more susceptible to EDS.

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Section: Discussionmentioning

confidence: 95%

Association Between Excessive Daytime Sleepiness and Functional Gastrointestinal Disorders: A Population-based Study in China

Chen

Zhao

et al. 2017

J Neurogastroenterol Motil

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“…148 Reported prevalence rates for FDr range from 1.5% to 17%. [149][150][151][152][153] C3. Diagnostic Criterion a for Functional Diarrhea…”

Section: Epidemiologymentioning

confidence: 99%

Bowel Disorders

et al. 2016

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Functional bowel disorders are highly prevalent disorders found worldwide. These disorders have the potential to affect all members of society, regardless of age, gender, race, creed, color or socioeconomic status. Improving our understanding of functional bowel disorders (FBD) is critical as they impose a negative economic impact to the global health care system in addition to reducing quality of life. Research in the basic and clinical sciences during the past decade has produced new information on the epidemiology, etiology, pathophysiology, diagnosis and treatment of FBDs. These important findings created a need to revise the Rome III criteria for FBDs, last published in 2006. This manuscript classifies the FBDs into five distinct categories: irritable bowel syndrome (IBS); functional constipation (FC); functional diarrhea (FDr); functional abdominal bloating/distention (FAB/D); and unspecified FBD (U-FBD). Also included in this article is a new sixth category, opioid induced constipation (OIC) which is distinct from the functional bowel disorders (FBDs). Each disorder will first be defined, followed by sections on epidemiology, rationale for changes from prior criteria, clinical evaluation, physiologic features, psychosocial features and treatment. It is the hope of this committee that this new information will assist both clinicians and researchers in the decade to come.

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“…It is a big problem in developing countries [3]. While the incidence of mortality due to childhood diarrhea has been declining in some industrialized countries [4], [5], [6], it is still an important source of morbidity in these regions [7].…”

Section: Introductionmentioning

confidence: 99%

Is Diurnal Temperature Range a Risk Factor for Childhood Diarrhea?

Huang

Turner

et al. 2013

PLoS ONE

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BackgroundPrevious studies have found that high and cold temperatures increase the risk of childhood diarrhea. However, little is known about whether the within-day variation of temperature has any effect on childhood diarrhea.MethodsA Poisson generalized linear regression model combined with a distributed lag non-linear model was used to examine the relationship between diurnal temperature range and emergency department admissions for diarrhea among children under five years in Brisbane, from 1st January 2003 to 31st December 2009.ResultsThere was a statistically significant relationship between diurnal temperature range and childhood diarrhea. The effect of diurnal temperature range on childhood diarrhea was the greatest at one day lag, with a 3% (95% confidence interval: 2%–5%) increase of emergency department admissions per 1°C increment of diurnal temperature range.ConclusionWithin-day variation of temperature appeared to be a risk factor for childhood diarrhea. The incidence of childhood diarrhea may increase if climate variability increases as predicted.

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Epidemiology of Functional Diarrhea and Comparison with Diarrhea-Predominant Irritable Bowel Syndrome: A Population-Based Survey in China

Cited by 50 publications

References 25 publications

Association Between Excessive Daytime Sleepiness and Functional Gastrointestinal Disorders: A Population-based Study in China

Association Between Excessive Daytime Sleepiness and Functional Gastrointestinal Disorders: A Population-based Study in China

Bowel Disorders

Is Diurnal Temperature Range a Risk Factor for Childhood Diarrhea?

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