Epidemiology of gout and hyperuricemia in New Caledonia

Abstract

Objectives. New Caledonia is a Paci c island of 270,000 inhabitants with mixed ethnicities, including Melanesians (39.1%), Polynesians (10.2%) and people from European ancestry (27.2%). This study aimed at determining the prevalence of gout and hyperuricemia in the general population and the various ethnicities of New Caledonia. Methods. A 3-degree random sample of the population aged 18 to 60 years was adjusted according to the 2014 New Caledonia census. Face-to-face planned interviews and physical measurements were performed by trained nurses. All consenting participants underwent capillary measurement of creatinine; all consenting men and only women older than 40 years underwent point-of-care uricemia testing . Gout was de ned by a validated algorithm. Two de nitions of hyperuricemia were used: capillary level equivalent to plasma uric acid level > 360 µmol/l (6 mg/dl) and > 420 µmol/l (7 mg/dl) and/or urate-lowering drug treatment for both thresholds.Results. We included 1.144 participants (adjusted mean age 37.7±12.0 years; adjusted sex ratio 50.4% men). The adjusted prevalence of gout was 3.3% (95% con dence interval 2.2-4.9). Prevalence was 6.7% (2.5-16.8), 4.1% (1.8-8.9), and 2.6% (1.4-4.7) for Polynesians, Europeans and Melanesians, respectively, and 1.9% (0.5-6.6) for other ethnicities. Prevalence of hyperuricemia, determined in 658 participants, was 67.0% (61.9-71.6) and 37.0% (32.3-42.0) for the 360-and 420-µmol/l thresholds, respectively, and was signi cantly greater for Polynesians and Melanesians than Europeans for both thresholds.Conclusions. The prevalence of gout and hyperuricemia in New Caledonia was high, including in patients of European descent. Key MessagesThis study is the rst to estimate the prevalence of gout in New Caledonia, a multiethnic Paci c island.The prevalence of gout was 3.3% (95% con dence interval 2.2-4.9) and varied across ethnicities.

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Cardiovascular safety of febuxostat versus allopurinol among the Asian patients with or without gout: A systematic review and meta‐analysis

“…Gout, a prevalent rheumatic metabolic disease, exhibits varying prevalence rates across different regions, countries, and races 1–3 . In the United Kingdom, the estimated prevalence of gout is 0.03%, whereas in Taiwan Province it is 10.42% 4 .…”

“…Gout, a prevalent rheumatic metabolic disease, exhibits varying prevalence rates across different regions, countries, and races. [1][2][3] In the United Kingdom, the estimated prevalence of gout is 0.03%, whereas in Taiwan Province it is 10.42%. 4 The incidence of gout is on the rise and is found in younger patients according to an epidemiologic study.…”