Epidemiology of group B streptococcal disease in infants younger than 1 year in Japan: a nationwide surveillance study 2016–2020

Epidemiology and bacterial characteristics of invasive group B streptococcus disease: a population-based study in Japan in 2010–2020

“…The incidence rate of per 1,000 live births was higher than the incidence rate of surveillance in 10 prefectures in Japan reported by Chang et al from 2007Chang et al from to 2012. In contrast, it was lower than the incidence rate reported by a nationwide surveillance of 343 hospitals in Japan in 2016-2020 [9]. The incidence of the present survey was different from those previous studies because of the differences of survey period, survey area and consideration of hospitalised cases in neighbouring prefectures.…”

“…Focusing on the bacterial profile, the most common serotype in this study was serotype III, which was the same as that reported in other domestic studies and studies conducted in other countries [9, 16, 20, 21]. Furthermore, the proportion of ST17, recognised as a hypervirulent international clone associated with invasive neonatal disease, was as high as 29.7% in 19 of the 64 patients aged <1 year in whom ST could be identified.…”

“…Accurate up-to-date information on the incidence of invasive GBS disease is fundamental in estimating vaccine efficacy and decision-making for GBS vaccine management as applicable country wise. However, limited information is available regarding the population-based incidence of invasive GBS disease among children in Japan [7][8][9]. In this study, the incidence and clinical manifestations of invasive GBS disease in children in Chiba Prefecture, Japan, were investigated and the serotypes and drug susceptibility of isolated GBS strains during the study period of 11 years analysed.…”

Clonal Complex 12 Serotype Ib Streptococcus agalactiae Strain Causing Complicated Sepsis in Neonates: Clinical Features and Genetic Characteristics

“…These subgroupings aid in the development of vaccines, the investigation of genetic evolution, and the tracking of transmission routes and probable clonal expansion and potentially contribute to preventive strategies ( 15 – 17 ). Although the type III CC17 GBS strain is well known to have caused the majority of cases of neonatal sepsis and meningitis in recent decades ( 17 – 19 ), the serotype Ib GBS strain was recently reported to be emerging with high incidence in Asia, especially in southeast China and Japan ( 20 – 23 ). The type Ib GBS strain is worthy of continuous monitoring due to its multidrug resistance and considerably high association with severe sepsis ( 20 – 23 ), but the relevant data regarding its molecular and genetic properties remain limited.…”

“…Although the type III CC17 GBS strain is well known to have caused the majority of cases of neonatal sepsis and meningitis in recent decades ( 17 – 19 ), the serotype Ib GBS strain was recently reported to be emerging with high incidence in Asia, especially in southeast China and Japan ( 20 – 23 ). The type Ib GBS strain is worthy of continuous monitoring due to its multidrug resistance and considerably high association with severe sepsis ( 20 – 23 ), but the relevant data regarding its molecular and genetic properties remain limited. We aimed to investigate the clinical and molecular characteristics of type Ib GBS isolates that cause severe invasive diseases in neonates.…”