Epidemiology of HCC in Brazil: Incidence and risk factors in a ten-year cohort

Paranaguá‐Vezozzo, Denise Cerqueira; Ono, Suzane Kioko; Alvarado-Mora, Mónica Viviana; Farias, Alberto Queiróz; Cunha-Silva, Marione; França, João Ítalo Dias; Alves, Venâncio Avancini Ferreira; Sherman, Morris; Carrilho, Flair José

doi:10.1016/s1665-2681(19)30845-2

Cited by 61 publications

(48 citation statements)

References 21 publications

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“…We reviewed 232 articles which potentially met the inclusion criteria in their entirety. After full article review, 22 articles fulfilled our criteria for inclusion in the systematic review and meta‐analysis (Figure ) …”

Section: Resultsmentioning

confidence: 99%

“…Although some prospective studies clearly described that no reminders were offered to patients, and some study protocols did not mention any measures to promote HCC surveillance completion, a number of factors may still contribute to higher adherence in a surveillance prospective study. First, patients selected and/or agreed to participate in a prospective study may be higher risk patients and/or more motivated patients, both of which will improve adherence .…”

Section: Discussionmentioning

confidence: 99%

“…Although some prospective studies clearly described that no reminders were offered to patients, 17,25,31 and some study protocols did not mention any measures to promote HCC surveillance completion, 22 Recognizing that our study contained high heterogeneity as a result of study design, we also analysed the data for only the retrospec- Although imaging with AFP had a higher surveillance rate than imaging only,we feel this may be a spurious result caused by very stringent and complicated surveillance protocols instituted separately from the accepted guidelines. An excellent example is found when reviewing the very high adherence rate in data from Japan; however, the Japanese HCC surveillance protocol is very rigorous and complicated.…”

Section: Discussionmentioning

confidence: 99%

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Poor adherence to hepatocellular carcinoma surveillance: A systematic review and meta‐analysis of a complex issue

Zhao

Jin

et al. 2017

Liver International

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Poor adherence to hepatocellular carcinoma surveillance: A systematic review and meta‐analysis of a complex issue

Zhao

Jin

et al. 2017

Liver International

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“…In this study, 75 of 453 (16.6%) patients developed HCC over 10 years - a higher incidence than the 8.1% observed in a cohort followed-up in the Southeast of Brazil[26]. Data from other countries also reveal higher incidences in various populations, such as 17.5% in the United States[27] and 27% in an Italian cohort[28].…”

Section: Discussionmentioning

confidence: 72%

Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study

Silva¹,

Miozzo²,

Dossin³

et al. 2016

WJG

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AIMTo determine the incidence of hepatocellular carcinoma (HCC) and the impact of HCC surveillance on early diagnosis and survival of cirrhotic outpatients.METHODSIn this retrospective cohort study, cirrhotic outpatients undergoing HCC surveillance between March 2005 and March 2014 were analyzed. Exclusion criteria were HIV coinfection; previous organ transplantation; diagnosis of HCC at first consultation; missing data in the medical chart; and less than 1 year of follow-up. Surveillance was carried out every six months using ultrasound and serum alpha-fetoprotein determination. Ten-year cumulative incidence and survival were estimated through Kaplan-Meier analysis.RESULTSFour hundred and fifty-three patients were enrolled, of which 57.6% were male. Mean age was 55 years. Hepatitis C virus and heavy use of alcohol were the main etiologic agents of cirrhosis. HCC was diagnosed in 75 patients (16.6%), with an estimated cumulative incidence of 2.6% in the 1st year, 15.4% in the 5th year, and 28.8% in the 10th year. Median survival was estimated at 17.6 mo in HCC patients compared to 234 mo in non-HCC patients (P < 0.001). Early-stage HCC was more often detected in patients who underwent surveillance every 6 mo or less (P = 0.05). However, survival was not different between patients with early stage vs non-early stage tumors [HR = 0.54 (0.15-1.89), P = 0.33].CONCLUSIONHCC is a frequent complication in patients with cirrhosis and adherence to surveillance programs favors early diagnosis.

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“…The majority of HCC cases occur in cirrhotic liver, and the primary risk factors are chronic hepatitis B virus or chronic hepatitis C virus (HCV) infection, which account for almost all HCC cases (2). The incidence of HCC varies between different geographical areas; however, it is increasing globally, particularly in Asia, with 6–11 per 100,000 people with the disease (3,4). A study of HCC epidemiology in Germany indicated that, despite the availability of various advanced chemotherapies and radiotherapies, including chemoembolization with drug-eluting beads, sorafenib and selective internal radiotherapy, the overall survival rate has not improved (5).…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics analysis of gene expression alterations in microRNA-122 knockout mice with hepatocellular carcinoma

Shi

et al. 2017

Molecular Medicine Reports

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Reduced microRNA (miR)-122 expression levels are frequently observed in hepatocellular carcinoma (HCC). The present study was conducted to investigate potential targets of miR-122 and determine the underlying regulatory mechanisms of miR-122 in HCC development. The public dataset GSE31731 was utilized, consisting of 8 miR-122 knockout (KO) mice (miR-122 KO) and 8 age-matched wild-type mice (WT group). Following data preprocessing, the differentially expressed genes (DEGs) were selected, followed by enrichment analysis. A protein-protein interaction (PPI) network was established, and a module network was further extracted. Combining the DEGs with microRNA targeting databases permitted the screening of the overlapping targets of miR-122. Furthermore, previously reported genes were screened out by literature mining. Transcription factors (TFs) of the targets were subsequently investigated. DEGs between miR-122 KO and WT groups were selected, including 713 upregulated and 395 downregulated genes. Of these, upregulated genes were enriched in cell cycle-associated processes [including nucleolar and spindle associated protein 1 (NUSAP1)], the cytokine-cytokine receptor interaction pathway [including C-X-C motif chemokine receptor 4 (CXCR4) and C-C motif chemokine receptor 2 (CCR2)], and the extracellular matrix-receptor interaction pathway [including integrin subunit alpha V (ITGAV)]. In addition, multiple overlapping targets were highlighted in the PPI network, including NUSAP1, CXCR4, CCR2 and ITGAV. Notably, CXCR4 and CCR2 were linked in module C, enriched in the cytokine-cytokine receptor interaction pathway. Furthermore, upregulated sex determining region Y-box 4 (SOX4) was identified as a TF. The results of the present study may provide a theoretical basis for further studies on the mechanisms of miR-122 in the development of HCC.

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Epidemiology of HCC in Brazil: Incidence and risk factors in a ten-year cohort

Cited by 61 publications

References 21 publications

Poor adherence to hepatocellular carcinoma surveillance: A systematic review and meta‐analysis of a complex issue

Poor adherence to hepatocellular carcinoma surveillance: A systematic review and meta‐analysis of a complex issue

Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study

Bioinformatics analysis of gene expression alterations in microRNA-122 knockout mice with hepatocellular carcinoma

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