Epidemiology of Head and Neck Cancer

Rettig, Eleni M.; D’Souza, Gypsyamber

doi:10.1016/j.soc.2015.03.001

Cited by 422 publications

(440 citation statements)

References 121 publications

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“…22,23 The proportion of HPV-associated oropharyngeal cancers is currently growing in the Western world, with prevalence estimates in the United States approaching 80%. 6 As a result, the ratio of oropharyngeal cancer to other HN cancers is around 30% in Western practice, which is substantially different from Asian population (12%) and Thailand (< 10%). 4,24 Meta-analysis studies suggest that HPV prevalence in oropharyngeal cancer is low in the Asia Pacific region.…”

Section: Oropharyngeal Cancermentioning

confidence: 99%

“…Association with oral cancer is not so strong. 6,17 Several local studies addressed the prevalence of HPV in oral squamous cell carcinoma, and found HPV rate 3-30%, depending on the technique employed. [18][19][20] Mouth cancer: Major locations of this multisite entity were floor of mouth and buccal mucosa.…”

Section: Oral Cavity Cancermentioning

confidence: 99%

“…6 Epidemiology of HN cancer often remains partially hidden, because many reports present the data according to specific sites of cancer instead of the HN cancer as a group. There is a significant variability in the definition of HN cancer.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of head and neck cancer in Thailand

Tangjaturonrasme

Vatanasapt

Bychkov

2017

Asia-Pac J Clncl Oncology

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Cancer is the most common cause of death in Thailand, with the mortality almost doubled during 1998-2011 (from 48.4 to 95.2 per 100 000). The estimated number of new cancer cases in 2011 was 112 392. Our review provides baseline data on the current epidemiological situation with head and neck (HN) cancer in Thailand based on reports of the National Cancer Registry and findings from local and international publications. Collectively, HN cancer approaches agestandardized rate (ASR) incidence of 15.7 and 10.7 per 100 000 males and females, respectively, and is ranked among the top five dominant cancers in Thailand. The leading HN malignancies in men are oral (ASR incidence 4.6 per 100 000), nasopharyngeal (ASR 2.8) and laryngeal (ASR 2.7) cancers, while the most common cancers in women are thyroid (ASR 5.1) and oral (ASR 3.2) carcinomas. Some local habits (betel quid chewing, traditional cigarette smoking and alcohol intake) are associated with the high incidence of oral cancer in Northeast Thailand. Despite important prognostic significance, the role of human papillomavirus infection in various HN cancers from Thailand has been scarcely addressed. There is a growing incidence of thyroid cancer over the last two decades. The Thai population overall, compared to worldwide rates of HN malignancies, has a lower incidence of laryngeal and thyroid cancers but higher incidence of nasopharyngeal cancer. K E Y

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Section: Oropharyngeal Cancermentioning

confidence: 99%

Section: Oral Cavity Cancermentioning

confidence: 99%

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Epidemiology of head and neck cancer in Thailand

Tangjaturonrasme

Vatanasapt

Bychkov

2017

Asia-Pac J Clncl Oncology

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“…Other risk factors are smoking, anal intercourse and high number of sexual partners [20]. Head and neck cancers are squamous cell carcinomas arising in the upper respiratory and digestive tract: oral cavity, oropharynx, hypopharynx and larynx, while nasopharynx and salivary glands cancers differ histologically [67]. It is estimated that in 2002 there were 405,000 new cases in the world with 211,000 deaths, and two-thirds of these cases occurred in developing country areas [62].…”

Section: Related Pathologiesmentioning

confidence: 99%

Human papillomavirus (HPV) infection: a Mozambique overview

2016

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Human Papillomavirus is agent of the most common sexually transmitted disease which is able to infect mucosal and cutaneous membranes of the anogenital region, upper aerodigestive tract, and other head and neck mucosal regions. Although mainly HPV infection can be asymptomatic and transient, it may persist and give rise to various lesions such as warts, condyloma dysplasia and cancers depending on low or high risk type of HPV infection. Moreover, growing recent evidence suggests a role of this virus in male and female fertility. To date no effective prevention, test, treatment and control strategies are provided for people in developing countries despite the reported high incidence of HPV both in women and men. This paper reviews the more recent literature about HPV infection highlighting epidemiology, related pathologies and possible fertility effects of HPV in male and female with particular attention to the Mozambique context.

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“…Each year, HNSCC is diagnosed in over 50,000 Americans and 600,000 people worldwide 1. Nearly half die of their disease, and survivors often suffer significant morbidity affecting voice, speech, taste, dental health, and swallowing.…”

Section: Introductionmentioning

confidence: 99%

Genomics and advances towards precision medicine for head and neck squamous cell carcinoma

Waes

Musbahi

2017

Laryngoscope Investig Oto

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ObjectiveTo provide a review of emerging knowledge from genomics and related basic science, preclinical, and clinical precision medicine studies in head and neck squamous cell carcinoma (HNSCC).Data SourcesThe Cancer Genome Atlas Network (TCGA) publications, PubMed‐based literature review, and ClinicalTrials.gov.Review MethodsTCGA publications, PubMed, and ClinicalTrials.gov were queried for genomics and related basic science, preclinical, and developmental clinical precision medicine studies in HNSCC.ResultsTCGA reported comprehensive genomic analyses of 279 HNSCC, defining the landscape and frequency of chromosomal copy number alterations, mutations, and expressed genes that contribute to pathogenesis, prognosis, and resistance to therapy. This provides a road map for basic science and preclinical studies to identify key pathways in cancer and cells of the tumor microenvironment affected by these alterations, and candidate targets for new small molecule and biologic therapies.ConclusionRecurrent chromosomal abnormalities, mutations, and expression of genes affecting HNSCC subsets are associated with differences in prognosis, and define molecules, pathways, and deregulated immune responses as candidates for therapy. Activity of molecularly targeted agents appears to be enhanced by rational combinations of these agents and standard therapies targeting the complex alterations that affect multiple pathways and mechanisms in HNSCC.Level of EvidenceNA.

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Epidemiology of Head and Neck Cancer

Cited by 422 publications

References 121 publications

Epidemiology of head and neck cancer in Thailand

Epidemiology of head and neck cancer in Thailand

Human papillomavirus (HPV) infection: a Mozambique overview

Genomics and advances towards precision medicine for head and neck squamous cell carcinoma

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