Epidemiology of healthcare-associated infections and mechanisms of antimicrobial resistance of responsible pathogens in Ukraine: a multicentre study

Salmanov, Aidyn G; Shchehlov, D.V.; Svyrydiuk, O.E.; Bortnik, Ihor M.; Mamonova, M.Yu.; Korniyenko, S. M.; Rud, Victor; Artyomenko, Volodymyr; Gudym, M.S.; Maliarchuk, Rostyslav; Bondar, Taras

doi:10.1016/j.jhin.2022.10.007

Cited by 31 publications

(10 citation statements)

References 22 publications

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“…This is probably attributable to the medical evacuation of patients from Ukrainian hospitals. OXA-type and NDM-1 have been reported as the most frequent alleles among carbapenemase-positive MDRO causing hospital-acquired infections in Ukraine, but carbapenemase allele combinations were not reported [ 8 ]. Limitations of our study are the lack of denominator data, including how the number of MDRO from patients from Ukraine relates to the total number of patients, the monthly number of hospitalisations in the Netherlands, and how many patients from Ukraine have been screened for MDRO or how many were not colonised with an MDRO.…”

Section: Discussionmentioning

confidence: 99%

“…The European Centre for Disease Prevention and Control (ECDC) advised to pre-emptively isolate patients transferred from hospitals in Ukraine or with a history of hospital admission in Ukraine in the last 12 months and to screen for carriage of MDRO [ 6 ]. Available information from Ukrainian military and general hospitals indicates high prevalence of MDRO in Ukraine between 2014 and 2021 [ 3 , 7 , 8 ]. Percentages of resistance of 17–84% against third-generation cephalosporins and carbapenems among Enterobacterales and P. aeruginosa , and > 50% resistance to carbapenems, fluoroquinolones and aminoglycosides among Acinetobacter species have been reported [ 3 , 7 , 8 ].…”

Section: Multidrug-resistant Organisms In the Netherlands And Ukrainementioning

confidence: 99%

“…Available information from Ukrainian military and general hospitals indicates high prevalence of MDRO in Ukraine between 2014 and 2021 [ 3 , 7 , 8 ]. Percentages of resistance of 17–84% against third-generation cephalosporins and carbapenems among Enterobacterales and P. aeruginosa , and > 50% resistance to carbapenems, fluoroquinolones and aminoglycosides among Acinetobacter species have been reported [ 3 , 7 , 8 ]. European surveillance data for Ukraine indicated 18% of S. aureus to be meticillin-resistant, while 41% meticillin-resistance was reported in healthcare-associated S. aureus infections [ 3 , 8 ].…”

Section: Multidrug-resistant Organisms In the Netherlands And Ukrainementioning

confidence: 99%

“…Percentages of resistance of 17–84% against third-generation cephalosporins and carbapenems among Enterobacterales and P. aeruginosa , and > 50% resistance to carbapenems, fluoroquinolones and aminoglycosides among Acinetobacter species have been reported [ 3 , 7 , 8 ]. European surveillance data for Ukraine indicated 18% of S. aureus to be meticillin-resistant, while 41% meticillin-resistance was reported in healthcare-associated S. aureus infections [ 3 , 8 ]. However, these percentages are based on isolates from hospitalised patients and may therefore not be representative for MDRO carriage in the community [ 3 , 7 ].…”

Section: Multidrug-resistant Organisms In the Netherlands And Ukrainementioning

confidence: 99%

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Multidrug-resistant organisms in patients from Ukraine in the Netherlands, March to August 2022

et al. 2022

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Since March 2022, there has been an emergence of multidrug-resistant organisms (MDRO) in the Netherlands in patients originating from Ukraine (58 patients, 75 isolates). For about half of these patients, recent hospitalisation in Ukraine was reported. Genomic surveillance revealed that the majority of the MDRO represent globally spread epidemic lineages and that 60% contain New Delhi metallo-β-lactamase (NDM) genes. Professionals should be aware of an increase in such MDRO associated with migration and medical evacuation of people from Ukraine.

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Section: Discussionmentioning

confidence: 99%

Section: Multidrug-resistant Organisms In the Netherlands And Ukrainementioning

confidence: 99%

Section: Multidrug-resistant Organisms In the Netherlands And Ukrainementioning

confidence: 99%

Section: Multidrug-resistant Organisms In the Netherlands And Ukrainementioning

confidence: 99%

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Multidrug-resistant organisms in patients from Ukraine in the Netherlands, March to August 2022

et al. 2022

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“…However, a study performed in an endemic setting indicated a decline in carbapenem-resistant Klebsiella pneumoniae infections, potentially as a result of COVID-19 prevention measures [ 31 ]. The potential of endemicity may be due to both successful clones and the potential for rapid, horizontal transferring of plasmid-mediated resistance such as carbapenemases and extended-spectrum beta-lactamases, with several examples globally [ 32 ]. With this potential in mind, prevention of resistant Gram-negative bacteria with mobile genetic elements should be intensified in the coming years, particularly with the reopening of international travel.…”

Section: Discussionmentioning

confidence: 99%

The epidemiology of multidrug-resistant organisms in persons diagnosed with cancer in Norway, 2008–2018: expanding surveillance using existing laboratory and register data

Danielsen,

Elstrøm,

Eriksen-Volle

et al. 2023

Eur J Clin Microbiol Infect Dis

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Surveillance has revealed an increase of multidrug-resistant organisms (MDROs), even in low-prevalent settings such as Norway. MDROs pose a particular threat to at-risk populations, including persons with cancer. It is necessary to include such populations in future infection surveillance. By combining existing data sources, we aimed to describe the epidemiology of MDROs in persons diagnosed with cancer in Norway from 2008 to 2018. A cohort was established using data from the Cancer Registry of Norway, which was then linked to notifications of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin- and/or linezolid-resistant enterococci (V/LRE), and carbapenemase-producing Gram-negative bacilli (CP-GNB) from the Norwegian Surveillance System for Communicable Diseases, and laboratory data on third-generation cephalosporin-resistant Enterobacterales (3GCR-E) from Oslo University Hospital (OUH). We described the incidence of MDROs and resistance proportion in Enterobacterales from 6 months prior to the person’s first cancer diagnosis and up to 3 years after. The cohort included 322,005 persons, of which 0.3% (878) were diagnosed with notifiable MDROs. Peak incidence rates per 100,000 person-years were 60.9 for MRSA, 97.2 for V/LRE, and 6.8 for CP-GNB. The proportion of 3GCR-E in Enterobacterales in blood or urine cultures at OUH was 6% (746/12,534). Despite overall low MDRO incidence, there was an unfavourable trend in the incidence and resistance proportion of Gram-negative bacteria. To address this, there is a need for effective infection control and surveillance. Our study demonstrated the feasibility of expanding the surveillance of MDROs and at-risk populations through the linkage of existing laboratory and register data.

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Moving toward point-of-care surgery in Ukraine: testing an ultra-portable operating room in an active war zone

Lagazzi,

Teodorescu,

Argandykov

et al. 2024

Eur J Trauma Emerg Surg

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Epidemiology of healthcare-associated infections and mechanisms of antimicrobial resistance of responsible pathogens in Ukraine: a multicentre study

Cited by 31 publications

References 22 publications

Multidrug-resistant organisms in patients from Ukraine in the Netherlands, March to August 2022

Multidrug-resistant organisms in patients from Ukraine in the Netherlands, March to August 2022

The epidemiology of multidrug-resistant organisms in persons diagnosed with cancer in Norway, 2008–2018: expanding surveillance using existing laboratory and register data

Moving toward point-of-care surgery in Ukraine: testing an ultra-portable operating room in an active war zone

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