Epidemiology of Helicobacter in Chinese families: a foundation for cost-effective eradication strategies?

Marshall, Barry J.

doi:10.1136/gutjnl-2023-329786

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Helicobacter pylori virulence factors such as cytotoxin-associated gene A (CagA), vacuolating cytotoxin A (VacA), and Helicobacter pylori neutrophil-activating protein (HP-NAP) significantly affect the function of DCs in tumor microenvironment or bone marrow-derived DCs and play an important role in the induction of GC ( Fu and Lai, 2023 ; Raspe et al, 2023 ; Yuan et al, 2023 ). The Treg cell-mediated inflammatory response caused by H. pylori infection ( Bagheri et al, 2016 , 2018 ; Owyang et al, 2020 ) and the genome instability caused by CagA ( Bagheri et al, 2018 ; Takahashi-Kanemitsu et al, 2020 ; Alipour, 2021 ; Imai et al, 2021 ; Murata-Kamiya and Hatakeyama, 2022 ; Marshall, 2023 ) have been extensively studied. Recent research has shown that H. pylori can inhibit miRNA-375 expression in the stomach.…”

Section: Discussionmentioning

confidence: 99%

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

Ke,

Tan,

Zhen

et al. 2024

Front. Microbiol.

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BackgroundNumerous studies have cast light on the relationship between the gastric microbiota and gastric carcinogenesis. In this study, we conducted a bibliometric analysis of the relevant literature in the field of gastric cancer and the gastric microbiota and clarified its research status, hotspots, and development trends.Materials and methodsPublications were retrieved from the Web of Science Core Collection on 18 July 2023. CiteSpace 6.2.R4, VOSviewer 1.6.19.0, and Biblioshiny were used for the co-occurrence and cooperation analyses of countries, institutions, authors, references, and keywords. A keyword cluster analysis and an emergence analysis were performed, and relevant knowledge maps were drawn.ResultsThe number of published papers in this field totaled 215 and showed an increasing trend. The analysis of funding suggested that the input in this field is increasing steadily. China had the highest number of publications, while the United States had the highest betweenness centrality. Baylor College of Medicine published the most articles cumulatively. Both Ferreira RM and Cooker OO had the highest citation frequency. The journal Helicobacter showed the most interest in this field, while Gut provided a substantial research foundation. A total of 280 keywords were obtained using CiteSpace, which were primarily focused on the eradication and pathogenic mechanisms of Helicobacter pylori, as well as the application of the gastric microbiota in the evaluation and treatment of gastric cancer. The burst analysis suggested that in the future, research may focus on the application of gastric microorganisms, particularly Fusobacterium nucleatum, in the diagnosis and treatment of gastric cancer, along with their pathogenic mechanisms.ConclusionCurrent studies have been tracking the eradication of Helicobacter pylori and its pathogenic mechanisms, as well as changes in the gastric microbiota during gastric carcinogenesis. Future research may focus on the clinical application and pathogenesis of stomach microorganisms through bacteria such as Fusobacterium nucleatum.

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Section: Discussionmentioning

confidence: 99%

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

Ke,

Tan,

Zhen

et al. 2024

Front. Microbiol.

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“…The primary difference between family-based screening and conventional strategies lies in the order of individual screening during the procedure, despite the ultimate objective being unchanged of testing the entire population. 57 The latest guideline from China provided feasible eradication treatment for completing the family screening strategy. 40 Also, compared with a genetic cause, H. pylori has a larger role in GC development.…”

Section: Existing H Pylori Management Strategiesmentioning

confidence: 99%

Prevention and Screening of Gastric Cancer by Helicobacter pylori Management: Synthesis of Existing Data

Zhou,

Li,

2023

Cancer Screen Prev

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Gastric cancer (GC) is a preventable disease, and Helicobacter pylori infection is the most important controllable risk factor. Despite numerous studies confirming that eradicating H. pylori can reduce the risk of GC, there remains a significant gap between the fundamental and clinical knowledge and public health interventions. This article provides a review of the progress made in the last decade by gastroenterologists in understanding the carcinogenic effects of H. pylori. The authors also summarize the evidence demonstrating the beneficial effects of eradication of H. pylori on gastric precancerous lesions and GC, and outline current strategies for H. pylori management. Notably, a family-based approach to H. pylori management represents a novel strategy for future GC prevention and control, boasting numerous advantages and having the potential to play a crucial role in future policymaking.

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Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy

Yin,

Lai,

Zhang

et al. 2024

Advanced Science

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Helicobacter pylori (H. pylori) is a primary pathogen associated with gastrointestinal diseases, including gastric cancer. The increase in resistance to antibiotics, along with the adverse effects caused by complicated medication protocols, has made the eradication of H. pylori a more formidable challenge, necessitating alternative therapeutics. Herein, a targeted nanoplatform is reported based on sonodynamic therapy, the chitosan‐conjugated fucose loaded with indocyanine green (ICG@FCS). It penetrates the gastric mucosa and homes in on H. pylori through dual targeting mechanisms: molecular via fucose and physical via ultrasound. Upon ultrasound activation, it generates singlet oxygen, effectively attacking planktonic bacteria, disrupting biofilms, and facilitating the clearance of intracellular bacteria by promoting autophagy, including multidrug‐resistant strains. The ICG@FCS nanoplatform minimally affects the gut microbiota and aids in gastric mucosa repair. a holistic integrative H. pylori therapy strategy is proposed that targets eradication while preserving gastrointestinal health. This strategy emphasizes the importance of maintaining patient health while eradicating the pathogen. This advancement is set to refine the comprehensive antibacterial approach, offering a promising horizon in the ongoing battle against antibiotic resistance and more effective gastric cancer prevention strategies.

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Epidemiology of Helicobacter in Chinese families: a foundation for cost-effective eradication strategies?

Cited by 4 publications

References 6 publications

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

Prevention and Screening of Gastric Cancer by Helicobacter pylori Management: Synthesis of Existing Data

Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy

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