Epidemiology of Helicobacter pylori in an asymptomatic population in the United States

Graham, David Y.; Malaty, Hoda M.; Evans, Dolores G.; Evans, Doyle J.; Klein, Peter; Adam, Ervín

doi:10.1016/0016-5085(91)90644-z

Cited by 858 publications

(524 citation statements)

References 32 publications

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“…In an adult cohort from the United States, positive H. pylori serology ranged from 16.7% for persons 20-29 years old to 56.9% for persons of age 70 or greater, demonstrating a clear age-related prevalence [75]. Within the United States, a higher frequency of infection has been demonstrated in non-Hispanic blacks and Mexican Americans [75,76].…”

Section: About H Pylorimentioning

confidence: 96%

Helicobacter pylori eradication: Novel therapy for immune thrombocytopenic purpura? A review of the literature

et al. 2005

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Eradication of Helicobacter pylori (H. pylori ) from the gastric mucosa has been associated with improvement of several systemic diseases, including immune thrombocytopenic purpura (ITP). Over the last 5 years, several studies have reported improved platelet counts in H. pylori-positive ITP patients following standard triple H. pylori eradication therapy. Review of published studies in which eradication of H. pylori has been performed in the ITP population indicates an overall response rate of 52% in 193 subjects in whom H. pylori was eradicated. Cohorts from Japan and Italy report higher response rates. There is no established mechanism to explain how this organism, which does not invade the gastric mucosa, could be implicated in the pathogenesis of this immune-based platelet disorder. Several theories including molecular mimicry, platelet aggregation, and immunomodulatory effects of macrolides have been proposed to explain the platelet response to anti-H. pylori therapy. Large randomized-controlled studies enrolling patients from various ethnic backgrounds will be necessary to determine the response rate and mechanism of response and to gain a better understanding of the pathogenesis of ITP. Am.

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Section: About H Pylorimentioning

confidence: 96%

Helicobacter pylori eradication: Novel therapy for immune thrombocytopenic purpura? A review of the literature

et al. 2005

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“…Graham & Malaty, 49,51 em 1992 e 1994, na área metropolitana de Houston, nos EUA, desenvolveram estudos envolvendo adultos assintomáticos da raça negra, branca e hispânicos, encontrando prevalência para H. pylori significativamente menor em indivíduos brancos e expressiva relação inversa entre o baixo nível socioeconômico na infância e a presença de infecção, mesmo após correção de fatores de confusão, a despeito do nível socioeconômico na época da pesquisa.…”

Section: Etniaunclassified

“…Estudos realizados por Graham et al 49 e Fiedorek et al, 36 nos EUA, entre os poucos existentes abordando diretamente esse aspecto, demonstraram que a infecção pelo H. pylori apresenta relação inversa à renda familiar.…”

Section: Renda Familiarunclassified

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Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

2002

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Descritores ResumoRealizou-se revisão da epidemiologia da infecção pelo Helicobacter pylori, com o objetivo de analisar sua importância na infância e adolescência no que se refere à incidência, à prevalência, às vias de transmissão e aos fatores de risco. Para tanto, realizou-se uma pesquisa nas bases de dados Lilacs (OPS/Bireme) e Medline (National Library of Medicine) e no banco de teses da Universidade de São Paulo dos anos de 1983 a 1999. A análise da literatura levou à conclusão de que a infecção pelo Helicobacter pylori é adquirida principalmente durante a infância, apresenta aumento da prevalência com a idade, os principais fatores de riscos estão relacionados ao baixo nível socioeconômico e o mecanismo de transmissão permanece desconhecido. AbstractThe scope of the review is to study the epidemiological aspects of Helicobacter pylori infection and its importance during childhood and adolescence, focusing on incidence, prevalence, transmission and risk factors. The study's references included the following databases: LILACS (PAHO/ Bireme), MEDLINE, the US's National Library of Medicine and the thesis developed at University of São Paulo for the period 1983 to 1999. It was noted that Helicobacter pylori infection is mainly acquired during childhood, age-related prevalence, main risk factors are associated to low socioeconomic status, and its transmission mechanism remains unclear.

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“…To date, accumulating data has showed that host genetic factors contribute to the susceptibility to H. pylori infection. For example, there are differences in H. pylori susceptibility between African Americans and US residents of European ancestry after adjusting for socioeconomic status, age and living conditions (Graham et al, 1991). Approximately 5% to 10% of a population is never infected with H. pylori, even in the presence of high exposure rates (Bardhan, 1997).…”

Section: Discussionmentioning

confidence: 99%

Common Genetic Variations in the MUC5AC Gene are Not Related to Helicobacter pylori Serologic Status

Zhou

Zhang²,

Gao³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Several lines of evidence suggest that MUC5AC genetic polymorphisms might confer susceptibility to H. pylori infection and therefore gastric cancer risk. We here assessed the association of common polymorphisms in the MUC5AC gene with H. pylori seroprevalence using an LD-based tagSNP approach in a north-western Chinese Han population. A total of 12 tagSNPs were successfully genotyped among 281 unrelated ethnic Han Chinese who had no cancer history, and no identifiable gastric disease or genetic disease. No significant association between any alleles, genotypes or haplotypes and H. pylori seroprevalence was observed. Our results suggest that common genetic variations in MUC5AC gene might not make a major contribution to the risk of H. pylori infection.

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Epidemiology of Helicobacter pylori in an asymptomatic population in the United States

Cited by 858 publications

References 32 publications

Helicobacter pylori eradication: Novel therapy for immune thrombocytopenic purpura? A review of the literature

Helicobacter pylori eradication: Novel therapy for immune thrombocytopenic purpura? A review of the literature

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

Common Genetic Variations in the MUC5AC Gene are Not Related to Helicobacter pylori Serologic Status

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