Epidemiology of hepatitis C Virus infection in an area of Southern Italy

Osella, Alberto Rubén; Misciagna, Giovanni; Leone, Alfonso; Leo, Alfredo Di; Fiore, Giorgio

doi:10.1016/s0168-8278(97)80276-0

Cited by 88 publications

(71 citation statements)

References 23 publications

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“…Indeed, the most commonly identified genotypes (1b, 2a/2c) are the same as those identified most frequently in the general population in Italy, according to several seroepidemiologic population-based studies. [26][27][28][29] These results are consistent with those of a previous study on HCV prevalence among patients with lymphoproliferative disorders in whom no association with a specific HCV genotype was found. 5 In 2 studies, however, genotype 2a was more common among patients with monoclonal gammopathy than in patients without this disease.…”

Section: Discussionsupporting

confidence: 91%

Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study

Mele

Pulsoni

Bianco

et al. 2003

Blood

267

201

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Section: Discussionsupporting

confidence: 91%

Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study

Mele

Pulsoni

Bianco

et al. 2003

Blood

267

201

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“…In contrast, Mele et al (6) did not observe any difference in the distribution of HCV genotypes between Italian B-cell NHL patients and control subjects. The HCV genotype distribution observed among both groups was similar to previous estimates of the HCV genotype distribution among the Italian population (18)(19)(20).…”

Section: Prevalence Of Anti-hcv Abs And/or Hcv-rna and Hcv Genotypes supporting

confidence: 87%

Extrahepatic disorders of HCV infection: A distinct entity of B-cell neoplasia?

et al. 2010

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Abstract. Some infectious agents have been associated with B-cell lymphoma development. In the last decades, it has been demonstrated that patients infected by hepatitis C virus (HCV) are more likely to develop B-cell non-Hodgkin's lymphoma (NHL) than those uninfected. The prevalence of HCV-infection among NHL patients is reported in this review of all Italian studies on NHL and HCV infection, both case-control and case series. From 18 studies, the prevalence of anti-HCV antibodies in 2736 NHL patients was 19.7% (range: 8.3-37.1%). The association of HCV-infection with each NHL histotype in case-control studies is discussed. Molecular mechanisms by which HCV infection promotes B-cell NHL development is also explored and indicate that HCV-associated lymphomas may be a distinct entity. Clarification of these mechanisms may improve diagnosis, classification and therapy of this subset of NHL. Finally, treatment of HCV-positive patients with lymphoproliferative disorders are herein summarized and further support the notion that HCV infection contributes to the development of these pathologic conditions.

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“…Methodological details of this population-based study have been published previously [23,24]. In brief, in 1985, a random sample of 3,500 subjects (2,000 men and 1,500 women) aged ≥30 years was drawn from the electoral roll of Castellana Grotte (17,334 residents at the 1981 Census); 30% worked in the agricultural sector.…”

Section: Study Populationmentioning

confidence: 99%

Midlife Metabolic Profile and the Risk of Late-Life Cognitive Decline

Tortelli

Lozupone

Guerra

et al. 2017

JAD

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Abstract. Among metabolic syndrome components, the effects of higher plasma glucose levels on cognitive decline (CD) have been considered in few studies. We evaluated the associations among midlife glycemia, total cholesterol, high-density lipoprotein cholesterol, triglycerides, midlife insulin resistance [homeostasis model assessment for insulin resistance (HOMAindex)], and CD in the older subjects of the population-based MICOL Study (Castellana Grotte, Italy) at baseline (M1) and at follow-ups seven (M2) and twenty years later (M3). At M1, a dementia risk score and a composite cardiovascular risk score for dementia were calculated. For 797 subjects out of 833, we obtained a Mini-Mental State Examination (MMSE) score at M3, subdividing these subjects in three cognitive functioning subgroups: normal cognition, mild CD, and moderate-severe CD. Mean fasting glycemia at baseline was significantly higher in moderate-severe CD subgroup (114.6 ± 71.4 mg/dl) than in the normal cognition subgroup (101.2 ± 20.6). Adjusting for gender, age, and other metabolic components, higher fasting glycemia values both at M1 [odds ratio (OR) = 1.31; 95% confidence interval (CI): 1.08-1.59] and M2 (OR = 1.26; 95% CI: 1.01-1.57) were associated with an increased risk of moderate-severe CD. Mean HOMA index value was significantly higher in the moderate-severe CD subgroup (5.7 ± 9.4) compared to the normal cognition subgroup (2.9 ± 1.4) at M1. The dementia risk probability (MMSE < 24) increased moving through higher categories of the dementia risk score and decreased as long as the cardiovascular score increased. The present findings highlighted the indication to control blood glucose levels, regardless of a diagnosis of diabetes mellitus, as early as midlife for prevention of late-life dementia.

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Epidemiology of hepatitis C Virus infection in an area of Southern Italy

Cited by 88 publications

References 23 publications

Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study

Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study

Extrahepatic disorders of HCV infection: A distinct entity of B-cell neoplasia?

Midlife Metabolic Profile and the Risk of Late-Life Cognitive Decline

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