Epidemiology of Staphylococcus aureus Bacteremia in Children at a Single Center from 2002 to 2016

Abstract

Purpose: We aimed to investigate the epidemiological characteristics of Staphylococcus aureus bacteremia in Korean children. Methods: We retrospectively collected and analyzed data from the medical records of the patients with S. aureus bacteremia ≤18 years of age in Gil Medical Center from 2002 to 2016. Results: A total of 212 SAB cases were detected. The annual incidence of SAB from 2002 to 2016 ranged from 0.77 to 1.95 per 1,000 patients hospitalized. The neonate group (<28 days of age) and the pediatric group (28-18 years of age) were 51.4% (n=109) and 48.6% (n=103), respectively. According to the origin of infection, there were 93 cases (43.9%) of communityassociated (CA)-SAB and 119 cases (56.1%) of healthcare-associated (HA)-SAB. The rates of HA-SAB among the neonate group and among the pediatric group were 64.2% and 47.6%, respectively (P=0.015). There was no difference in complications between CA-SAB and HA-SAB, but mortality was higher in HA-SAB. The proportion of methicillin-resistance S. aureus (MRSA) was the highest in neonates (88.1%), decreased with age, and was 36.4%-37.5% among children aged ≥5 years. The MRSA proportion was 72.2%, showing no consistent trend over the period. Conclusions: The annual incidence of SAB and the proportion of MRSA in SAB remained constant in the recent 15 years in children. Judicious decision of antimicrobial agents for treatment considering the patient's age and the origin of infection is necessary.

The molecular epidemiology and clinical implication of methicillin-resistant Staphylococcus aureus (MRSA) sequence types in pediatric bacteremia: a restrospective observational study, 2016-2021

“…While MRSA rates in SAB have been decreasing in Europe and the United States since the 2000s [2,19,20], and a similar trend has been observed in adults in South Korea [21,22], the MRSA rate among SAB cases in Korean children remained high, ranging from 51.9-76.1% between 2002 to 2016 [5]. However, during the study period, the incidence of pediatric MRSA bacteremia decreased by 23% annually, with MRSA accounting for 47.5% of SAB cases.…”

“…MRSA bacteremia has been associated with higher mortality rates compared to methicillin-susceptible S. aureus (MSSA) bacteremia [4]. In Korea, the prevalence of methicillin-resistant S. aureus (MRSA) among pediatric patients with SAB admitted to a tertiary hospital was notably elevated, ranging from 65.2-76.1% between 2002 and 2016 [5].…”