Epidemiology of <i>Staphylococcus aureus</i> infections in patients admitted to freestanding pediatric hospitals, 2009–2016

Spaulding, Alicen B; Thurm, Cary; Courter, Joshua; Banerjee, Ritu; Gerber, Jeffrey S.; Newland, Jason G.; Parker, Sarah K.; Brogan, Thomas V.; Kronman, Matthew P.; Shah, Samir S.; Smith, Michael J.; Patel, Sameer; Lee, Brian; Hersh, Adam L.

doi:10.1017/ice.2018.259

Cited by 20 publications

(7 citation statements)

References 10 publications

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“…The stability in methicillin resistance among S. aureus cultures of community-onset infections differs from other epidemiologic studies that have reported decreases in methicillin resistance in pediatric S. aureus infections. [4][5][6] Most prior studies analyzed trends in hospitalized children, which may account for this difference and would align with our finding of MSSA predominance in invasive infections. The cause of national increases in invasive MSSA is unclear.…”

Section: Discussionsupporting

confidence: 85%

Trends in pediatric community-onset Staphylococcus aureus antibiotic susceptibilities over a five-year period in a multihospital health system

Prochaska

Xiao

Sick-Samuels

et al. 2023

ASHE

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The epidemiology of community-onset Staphylococcus aureus infections is evolving. We performed a multihospital, retrospective study of pediatric community-onset S. aureus susceptibilities between 2015 and 2020. Oxacillin and clindamycin susceptibility remained lower at 67% and 75%, respectively. Tetracycline and trimethoprim-sulfamethoxazole susceptibility remained high at >90%. Oxacillin susceptibility was highest in invasive infections.

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Section: Discussionsupporting

confidence: 85%

Trends in pediatric community-onset Staphylococcus aureus antibiotic susceptibilities over a five-year period in a multihospital health system

Prochaska

Xiao

Sick-Samuels

et al. 2023

ASHE

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“…The difference in the colonization rate may be attributed to the different study locations or periods. In the United States, a decline in the proportion of MRSA among S. aureus isolates (60.4% decrease) or a trend of MRSA infection (52% decrease) has been observed in the pediatric population since 2010 ( 17 , 18 ).…”

Section: Discussionmentioning

confidence: 99%

Community-Associated Methicillin-Resistant Staphylococcus Aureus Colonization in a Birth Cohort of Early Childhood: The Role of Maternal Carriage

Tsai

Chiu

et al. 2021

Front. Med.

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Background: Methicillin-resistant Staphylococcus aureus (MRSA) colonization in infants may pose a risk for subsequent infection in children. The study aimed to determine S. aureus colonization patterns in infancy, and strain relatedness between maternal and infant colonization.Methods: A prospective cohort study was conducted for nasopharyngeal S. aureus detection in neonates at delivery; in children at 1, 6, 12, 24, 36, and 60 months of age; and from mothers immediately after the delivery of their baby and when their child is 1 month old. A questionnaire for infants and mothers was administered at each planned visit.Results: In total, 521 and 135 infant–mother dyads underwent nasopharyngeal swab collection at 1 month and immediately after delivery, respectively. Among the 521 dyads at 1 month of age, concordant S. aureus colonization was found in 95 dyads, including MRSA in 48.4% (46/95). No concordant MRSA carriage was present among the 135 dyads at delivery. The genetic relatedness of concurrent MRSA-colonized dyads showed that more than two-thirds (32/46 [69.6%]) had identical genotypes, mainly ST 59/PVL-negative/SCCmec IV. Infants aged 1 month had the highest incidence of S. aureus, and the trend declined to a nadir at the age of 12 months. Carrier mothers who smoked cigarettes may increase the risk of infant Staphylococcus colonization (odds ratio, 2.12; 95% confidence interval, 1.23–3.66; p < 0.01).Conclusions: Maternal–infant horizontal transmission may be the primary source of MRSA acquisition in early infancy. The avoidance of passive smoking could be recommended for the prevention of S. aureus carriage.

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“…Globally, complicated skin and soft tissue infections (cSSTIs) and bacteremia due to Staphylococcus aureus are common causes of infection for children, and although infection rates have declined, methicillinresistant S. aureus (MRSA) remains a threat worldwide [1][2][3][4][5]. Methicillin-resistant strains continue to cause a large proportion of cSSTIs and bloodstream infections (bacteremia) caused by S. aureus [4].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of daptomycin in Japanese pediatric participants with complicated skin and soft tissue infections or bacteremia caused by gram-positive cocci

Iwata¹,

Koyama

Murata

2022

Journal of Infection and Chemotherapy

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Epidemiology of Staphylococcus aureus infections in patients admitted to freestanding pediatric hospitals, 2009–2016

Cited by 20 publications

References 10 publications

Trends in pediatric community-onset Staphylococcus aureus antibiotic susceptibilities over a five-year period in a multihospital health system

Trends in pediatric community-onset Staphylococcus aureus antibiotic susceptibilities over a five-year period in a multihospital health system

Community-Associated Methicillin-Resistant Staphylococcus Aureus Colonization in a Birth Cohort of Early Childhood: The Role of Maternal Carriage

Efficacy and safety of daptomycin in Japanese pediatric participants with complicated skin and soft tissue infections or bacteremia caused by gram-positive cocci

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