Epidemiology of idiopathic glomerular disease: A prospective study

Abstract

In this study incidence rates of idiopathic glomerular disease in 1.5 X 10(6) Dutch adults between 16 and 65 years of age were determined, as well as the prevalence of these diseases in terms of indication for renal biopsy. The study was conducted between 1978 and 1985; indications for renal biopsy in decreasing hierarchical order were recently discovered uremia, nephrotic syndrome, chronic hematuria of less than two years duration with or without proteinuria or disturbed renal function, and chronic proteinuria of less than two years duration, of unknown origin. The main findings are fourfold. The incidence of IgA nephropathy and thin glomerular basal membrane lesions was high, 19 and 13 per 10(6) adults respectively, and the prevalence in patients biopsied because of non-azotemic chronic hematuria was 31% and 22%, respectively. In the normotensive non-azotemic adults biopsied because of chronic, mild proteinuria the prevalence of focal segmental glomerular sclerosis and vascular hyalinosis was both 41%. Of the patients biopsied because of nephrotic syndrome the prevalence of membranoproliferative glomerulonephritis (5%) was low, as was the incidence (less than 2 per 10(6) adults per year). Finally, the prevalence of diffuse sclerosing glomerulonephritis was 25% in patients biopsied because of uremia. This study is useful for the differential diagnosis of idiopathic glomerular disease.

Estimating Renal Survival Using the ANCA-Associated GN Classification

“…Renal biopsy specimens were processed for light microscopy and immunofluorescence as previously described. 3,4 Biopsy specimens were termed pauci-immune when immunofluorescence was 2+ or less (on a scale of 0-4+) for any immunoglobulin or complement. 12 Renal biopsy specimens were scored independently and blinded from clinical information by two observers (P.V.B.V.…”

“…In contrast, Berden et al classified 13 of their 100 patients (13%) in the sclerotic group. In our study, we sought to make an early diagnosis of GN in patients with erythrocyturia and proteinuria, 3,4 possibly resulting in fewer sclerotic glomeruli.…”

“…2 To validate the ANCA-associated GN classification system (AGN classification), we scored all AAV renal biopsy specimens from patients with AAV who participated in the Limburg Renal Registry, a prospective renal biopsy study on glomerular diseases. 3,4 The database was searched for patients with pauci-immune necrotizing crescentic GN. 5 Two hundred twenty-one consecutive patients who underwent renal biopsy between January 1, 1979, and August 31, 2011, in the province of Limburg, The Netherlands, were identified as having pauci-immune necrotizing crescentic GN.…”

Kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin as prognostic markers in idiopathic membranous nephropathy

“…1 Natural history studies with follow-up of at least three years indicate that approximately 50% of patients with nephrotic iMN develop renal failure. [2][3][4] It has been demonstrated that a restrictive treatment strategy which limits immunosuppressive treatment to patients with established renal insufficiency results in good longterm renal survival.…”

Predicting the Renal Outcome and Correlation of Renal Parameters in IG-A Nephropathy using new Oxford-Mest Classification System

“…Diffuse and Focal Glomerulonephritis with Crescents are the dominant renal biopsy features. 6 Secondary causes of IgA deposits in Mesangium are [7][8][9][10] 1. Diseases of the liver: alcoholic, primary biliary, or cryptogenic cirrhosis; hepatitis B (where endemic); chronic schistosomiasis 2.…”