Epidemiology of infective endocarditis in Tunisia: a 10-year multicenter retrospective study

Létaief, A.; Boughzala, E.; Kaabia, N.; Ernez, S.; Abid, F; Chaabane, T. Ben; Jemâa, Mounir Ben; Boujnah, Rachid; Chakroun, M.; Daoud, M.; Gaha, Rafika; Kafsi, N; Khalfallah, A; Slimane, Lotfi; Zaoualí, Mohamed Amine

doi:10.1016/j.ijid.2006.10.006

Cited by 89 publications

(67 citation statements)

References 22 publications

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“…These two microorganisms have been reported as main etiological agents in 13-49% and 20-63% of the cases with native valve endocarditis, respectively (5,10,12). However, in our study cohort staphylococci and enterococci were the most frequently isolated causative agents in IE with the incidences of 29% and 11%, respectively.…”

Section: Discussioncontrasting

confidence: 48%

“…These changes are mainly being attributed to a number of factors including a marked reduction in the incidence of acute rheumatic disease and congenital heart disease, increase in cases of degenerative valvular disease, increasing patient longevity, increased use of invasive procedures and implanted medical devices (prosthetic valves, pacemaker, ICD and central vascular catheters etc.) (5,12). In a recent study conducted by Leblebicioğlu et al (14) from Turkey the mean age for IE was 45 years (112 adult patients), and in a study from Turkey by Çetinkaya et al (10) the patients were under the age of 40 years (228 patients).…”

Section: Discussionmentioning

confidence: 98%

“…IE is frequently associated with rheumatic valvular disease resulting in high morbidity and mortality in Turkey (10). In fact, most studies on IE from the developing world with few exceptions are single center studies (11,12).…”

Section: Introductionmentioning

confidence: 99%

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A multicenter study on experience of 13 tertiary hospitals in Turkey in patients with infective endocarditis

Elbey¹,

Akdağ²,

Kalkan³

et al. 2013

Anadolu Kardiyol Derg

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Objective: The aim of this retrospective multicenter study was to investigate the clinical manifestations, microbiological profile, echocardiographic findings and management strategies of infective endocarditis (IE) in Turkey. Methods: The study population consisted of 248 Turkish patients with IE treated at 13 major hospitals in Turkey from 2005 to 2012 retrospectively. All hospitals are tertiary referral centers, which receive patients from surrounding hospitals. Data were collected from the medical files of all patients hospitalized with IE diagnosed according to modified Duke Criteria. Results: One hundred thirty seven of the patients were males. Native valves were involved in 158 patients while in 75 participants there was prosthetic valve endocarditis. Vegetations were detected in 223 patients (89%) and 52 patients had multiple vegetations. Mitral valve was the most common site of vegetation (43%). The most common valvular pathology was mitral regurgitation. The most common predisposing factor was rheumatic valvular disease (28%). Positive culture rate was 65%. Staphylococci were the most frequent causative microorganisms isolated (29%) followed by enterococci (11%). In-hospital mortality rate was 33%. Conclusions: Compared to IE in developed countries younger age, higher prevalence of rheumatic heart disease, more frequent enterococci infection and higher rates of culture negativity were other important aspects of IE epidemiology in Turkey. (

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Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 98%

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A multicenter study on experience of 13 tertiary hospitals in Turkey in patients with infective endocarditis

Elbey¹,

Akdağ²,

Kalkan³

et al. 2013

Anadolu Kardiyol Derg

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“…Although IE patients included in the present study manifested with a wide range of signs and symptoms, in consistent with the previous studies, [7,8,[11][12][13][14][15][16][17][18] the most common symptom was fever (86.7%), while the most common physical examination finding was murmur (88.1%). The patients who received the diagnosis of IE within the first 30 days following symptom onset accounted only for 53.8% of the study population.…”

Section: Discussionsupporting

confidence: 88%

“…[11,12] The mean age of patients at IE onset is as low as 32 years in countries such as Tunisia and India. [13,14] Studies performed in Turkey in different time points reported the mean age at disease onset varying between 45 and 47 years. [15][16][17] Furthermore, IE develops more frequently in men; however, the reason underlying higher proportion of men is poorly understood, and the Guidelines on the prevention, diagnosis, and treatment of IE published by the European Society of Cardiology estimates a maleto-female ratio of 2:1.…”

Section: Discussionmentioning

confidence: 99%

Profile of infective endocarditis cases at a tertiary hospital in Turkey: our 15-year experience

Kocabaş¹,

Kaya²,

Çakan³

2017

Turk Gogus Kalp Dama

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ÖZ ABSTRACT Background:This study aims to evaluate the clinical, echocardiographic, and microbiological profile and in-hospital complication and mortality rates of infective endocarditis cases in the tertiary setting. Methods: A total of 210 consecutive cases (138 males, 72 females; mean age 48.8±17.9 years; range, 18 to 89 years) who were diagnosed with definite infective endocarditis based on the modified Duke criteria and treated between September 2000 and September 2015 were retrospectively analyzed. Results:The rate of prosthetic valve infective endocarditis was 12.3%. Rheumatic heart disease was the most common predisposing factor (20.5%). Transthoracic and/or transesophageal echocardiography showed a vegetation in 174 cases (82.9%). Causative microorganisms were identified in 119 cases (56.7%) as Staphylococci (30.5%), Streptococci (15.2%), and Enterococci (7.6%). Cultures were negative in 91 cases (43.3%). Surgical therapy was necessary in 111 cases (53%). Twenty-four percent of cases had a total recovery with appropriate antibiotheraphy without needing any surgical procedures. The most common complications were septic embolism (25.2%) and congestive heart failure (13.4%). In-hospital mortality occurred in 41 cases (19.5%). Conclusion: Our study results show that infective endocarditis is still associated with high in-hospital mortality and morbidity rates.

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North Africa

Gautret

Mouffok

Parola

2017

Infectious Diseases

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Epidemiology of infective endocarditis in Tunisia: a 10-year multicenter retrospective study

Abstract: Infective endocarditis is still frequently associated with rheumatic disease among young adults in Tunisia, with a high frequency of negative blood cultures and high in-hospital mortality, given that the population affected is relatively young.

Cited by 89 publications

References 22 publications

A multicenter study on experience of 13 tertiary hospitals in Turkey in patients with infective endocarditis

A multicenter study on experience of 13 tertiary hospitals in Turkey in patients with infective endocarditis

Profile of infective endocarditis cases at a tertiary hospital in Turkey: our 15-year experience

North Africa

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