Epidemiology of Inflammatory Bowel Disease from 1981 to 2014

Ng, Siew C.; Leung, Wai Keung; Shi, Hai; Li, Michael K K; Leung, Chi Man; Ng, Carmen; Lo, Fu Hang; Hui, Yee Tak; Tsang, Steven Woon Choy; Chan, Yiu Kay; Loo, Ching Kong; Chan, Kam Hon; Hui, Aric Josun; Chow, Wai Hung; Harbord, Marcus; Ching, Jessica Y. L.; Lee, Mandy; Chan, Victor; Tang, Whitney; Hung, Ivan F. N.; Ho, Judy W. C.; Lao, Wai Cheung; Wong, Margaret Wan Nar; Sze, Shun Fung; Shan, Edwin Hok Shing; Lam, Belsy C Y; Tong, Raymond Wai Hung; Mak, Lai Yee; Wong, Sai Ho; Wu, Justin C.Y.; Chan, Francis K.L.; Sung, Joseph J.Y.

doi:10.1097/mib.0000000000000846

Cited by 94 publications

(44 citation statements)

References 33 publications

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“…In both CD and UC, incidence peaked in the age interval 20–30 years; however, a second peak between the ages of 60–79 years was reported in UC. A similar age distribution has been reported in Asia, where the median age of diagnosis in patients with CD and UC was 34 and 42 years, respectively . In contrast to findings in West, a bimodal distribution was only seen in CD and not in UC in most Asian populations, where the incidence rate of CD peaked in the age ranges of 20–24 years and 40–44 years .…”

Section: Clinical Features Of Ibdsupporting

confidence: 79%

“…A similar age distribution has been reported in Asia, where the median age of diagnosis in patients with CD and UC was 34 and 42 years, respectively. 26,27 In contrast to findings in West, a bimodal distribution was only seen in CD and not in UC in most Asian populations, where the incidence rate of CD peaked in the age ranges of 20-24 years and 40-44 years. 13 However, a recent review suggested that there is an increase in elderly onset UC in the Japanese population, likewise, a questionnaire-based single-center study in Japan suggested a bimodal distribution of UC with incidence rate peaking at 10-20 years followed by smaller peaks at 40-44 years and 50-60 years 31,32 .…”

Section: Clinical Features Of Ibdcontrasting

confidence: 58%

“…25 In 2014, the adjusted prevalence of UC and CD in Hong Kong had risen to 24.5 and 18.6 per 100,000 individuals. 26 Study from South Korea revealed similar trends, where the prevalence of UC quadrupled from 7.6 per 100,000 individuals in 1997 to 30.9 in 2005. 27 Figure 3 summarizes the prevalence of IBD based on population-based cohort studies from 2010-2019.…”

Section: Introductionmentioning

confidence: 74%

“…In Taiwan, the prevalence of CD and UC between 2001 and 2015 has increased from 0.6 and 2.1 to 3.9 and 12.8, respectively, per 100,000 individuals . In 2014, the adjusted prevalence of UC and CD in Hong Kong had risen to 24.5 and 18.6 per 100,000 individuals . Study from South Korea revealed similar trends, where the prevalence of UC quadrupled from 7.6 per 100,000 individuals in 1997 to 30.9 in 2005 .…”

Section: Introductionmentioning

confidence: 90%

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The epidemiology of inflammatory bowel disease: East meets west

Mak

Zhao

et al. 2019

J of Gastro and Hepatol

446

291

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The incidence of inflammatory bowel diseases (IBD) in East has risen over the past decade to become a global disease. The increasing number of studies on the incidence and course of IBD in East has enabled us to explore East versus West differences in the epidemiology of IBD which could enhance our understanding of the heterogeneity of the disease and eventually assist in the discovery of novel therapeutic targets and design of preventive strategies. Comparison of population‐based data in East and West reveals that the incidence of IBD has risen rapidly in East while plateauing in West. Furthermore, the clinical presentation and course of IBD differs between East and West with more patients in East presenting with complicated disease. Considering the scarcity of population‐based data from East and the lack of studies with long durations of follow‐up, it remains to be clarified whether these differences reflect true differences in disease presentation. The effects of genetic and environmental risk factors contributing to IBD also differ between Eastern and Western populations. Considering the differential effects of genetic and environmental risk factors in East and West, future studies should seek to discover novel genetic and environmental risk factors which might specifically apply to eastern populations. In this narrative review, we compare the epidemiology of IBD between eastern and western countries by summarizing evidence from population‐based cohort studies in the last ten years. Furthermore, we look at differences in genetic susceptibility and environmental triggers of IBD between East and West.

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Section: Clinical Features Of Ibdsupporting

confidence: 79%

Section: Clinical Features Of Ibdcontrasting

confidence: 58%

Section: Introductionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 90%

See 2 more Smart Citations

The epidemiology of inflammatory bowel disease: East meets west

Mak

Zhao

et al. 2019

J of Gastro and Hepatol

446

291

View full text Add to dashboard Cite

show abstract

“…The burden of IBD in India and other Asian countries is rising 8910. Several studies from the West have determined the prevalence of IBD in the relatives of UC or CD patients.…”

Section: Introductionmentioning

confidence: 99%

Familial aggregation of inflammatory bowel disease in patients with ulcerative colitis

et al. 2017

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Background/AimsFamilial occurrence of inflammatory bowel disease (IBD) is well documented. Reports from Western countries have shown a higher familial occurrence of ulcerative colitis (UC) in first- and second-degree relatives than that in the Asian UC population. No data are currently available from the Indian subcontinent in this regard. We present our data on the familial aggregation of UC.MethodsRecords of patients with UC followed at the Inflammatory Bowel Disease Clinic at the All India Institute of Medical Sciences, New Delhi from August 2004 to January 2016 were reviewed. Details regarding the prevalence of family history and characteristics of these patients were recorded. Affected family members were contacted and disease characteristics were noted for assessment of familial aggregation.ResultsOf the 2,058 UC patients included in the analysis, a positive family history of IBD was confirmed in 31 patients (1.5%), 24 (77.4%) of whom had only first-degree relatives affected. All the affected relatives had UC and none had Crohn's disease. Among first-degree relatives, siblings were found to have the highest prevalence of IBD (53.3%), followed by parents (26.7%).ConclusionsThe probability of occurrence of IBD in family members of affected North Indian UC patients is lower than that reported in Western populations.

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Childhood antibiotics as a risk factor for Crohn's disease: The ENIGMA International Cohort Study

et al. 2022

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She is a scientific co-founder of GenieBiome limited and holds provisional patents for Therapeutic and Diagnostic Use of Bacteria in COVID-19 Infection, Therapeutic and Prophylactic Use of Microorganisms and Fecal Virome and Fecal Fungome and Therapeutic Efficacy of Fecal Microbiota Transplantation in recurrent clos difficile infections. Other authors have no conflicts of interests to declare.Author contribution: Joyce W Y Mak and Jessica Y L Ching had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. All authors were responsible for the study concept and design.

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Epidemiology of Inflammatory Bowel Disease from 1981 to 2014

Abstract: In a population-based study in Hong Kong, prevalence of IBD is lower than in the west although comparable to that of other East Asian countries. Complicated CD is common. Overall mortality remains low in Asians with IBD.

Cited by 94 publications

References 33 publications

The epidemiology of inflammatory bowel disease: East meets west

The epidemiology of inflammatory bowel disease: East meets west

Familial aggregation of inflammatory bowel disease in patients with ulcerative colitis

Childhood antibiotics as a risk factor for Crohn's disease: The ENIGMA International Cohort Study

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