Epidemiology of Invasive Early-Onset Neonatal Sepsis, 2005 to 2014

Schrag, Stephanie J.; Farley, Monica M.; Petit, Susan; Reingold, Arthur; Weston, Emily; Pondo, Tracy; Jain, Jennifer Hudson; Lynfield, Ruth

doi:10.1542/peds.2016-2013

Cited by 365 publications

(373 citation statements)

References 17 publications

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“…Despite the advances in neonatal medicine, EOS remains a potentially fatal condition that affects approximately 0.3–0.8/1,000 infants born at ≥35 weeks’ gestation in high-resource settings [1, 2]. Current neonatal sepsis management algorithms provide neither a satisfactory framework for consistent and objective risk assessment nor an estimate of patient-specific risks.…”

Section: Introductionmentioning

confidence: 99%

Implementation of the Neonatal Sepsis Calculator in an Australian Tertiary Perinatal Centre

et al. 2018

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Background: Early-onset sepsis (EOS) is a potentially fatal condition that affects about 0.3–0.8/1,000 infants born at ≥35 weeks’ gestation in developed countries. Current EOS management algorithms result in 8–15% of infants receiving antibiotics for suspected sepsis. The Neonatal Sepsis Calculator provides evidence-based estimates of individual sepsis risk, but data on its clinical application is limited. Objectives: To evaluate the feasibility, safety, and effect on the newborn infants that were investigated and that received antibiotic treatment for suspected EOS following the introduction of the Neonatal Sepsis Calculator. Methods: This was a prospective, observational, single-centre cohort study comparing the rates of newborn infants born at ≥35 weeks’ gestation requiring evaluation and/or treatment for suspected EOS in a large tertiary perinatal centre before versus after the prospective introduction of the Neonatal Sepsis Calculator (Epoch 1: October 2014 to January 2015 vs. Epoch 2: July to December 2016). Results: There were 1,732 and 2,502 eligible infants born during Epochs 1 and 2, respectively. Of these, 425 (24.2%) and 530 (21.2%), respectively, were admitted to the neonatal unit. The proportion of infants investigated for sepsis decreased from 15.2 to 11.1%, and that of infants treated with antibiotics from 12.0 to 7.6%. One case of EOS occurred during each Epoch. Conclusions: The implementation of the Neonatal Sepsis Calculator was feasible and safe in our unit. Application of this clinical decision support tool may reduce the number of infants undergoing investigations and empirical treatment for suspected EOS.

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Section: Introductionmentioning

confidence: 99%

Implementation of the Neonatal Sepsis Calculator in an Australian Tertiary Perinatal Centre

et al. 2018

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“…Sepsis and septic shock are recognized as one of the most frequent causes of mortal complications in neonatal intensive care units worldwide. It has been observed that early-onset sepsis has become a serious and common issue among neonates, especially preterm infants [2]. Neonatal period is the most critical stage in the life of newborn babies, and neonatal sepsis is one of the most common causes for mortality at this age.…”

Section: Introductionmentioning

confidence: 99%

Cardiac Function Affection in Infants with Neonatal Sepsis

Alzahrani¹

2017

J Clin Trial

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Objective: Neonatal sepsis is associated with the presence of the systemic inflammatory response syndrome (SIRS) in response to a culture-proven infection. It is known as one of the most frequent causes of mortality in the neonatal intensive care units. The study has aimed to investigate the effects of neonatal sepsis on cardiac function of the infants. Methods:The study is based on prospective cohort research. It consists of two groups; control group and focus group. The focus group comprised of 30 full-term neonates with neonatal sepsis admitted to NICU; whereas, healthy neonates were included in the control group. Neonatal sepsis was diagnosed among the infants with the presence of at least two clinical signs of sepsis including feeding intolerance, temperature instability, apnea, poor reflexes, poor capillary refill>2 seconds. The clinical examination of neonates including CBC, CRP, blood culture, and sensitivity was also conducted. Moreover, echocardiography was performed on participants of both groups. Results:The results revealed that 50% of the patients from both the groups were male. The mean weight of the infants ranged from 2.2 to 3.5 kg with a mean of 2.9 ± 0.3 kg. Results showed that 63.3% patients had low platelet count, and 16.7% patients suffered from leukocytosis. 11 patients (36.7%), suffering from sepsis, were diagnosed with significant shift in their neutrophil count. There were significant changes in the echocardiogram of the patients suffering neonatal sepsis; whereas, dramatic improvement in cardiac function was observed by comparing the parameters before and after resolution of sepsis. Conclusion:The septic neonates experienced significant cardiovascular changes that are revealed through the technique known as echocardiography.

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“…La vigilancia activa de las infecciones invasoras indica que la prevalencia de E. coli ha aumentado en los últimos años, como asimismo la frecuencia de resistencia a ampicilina (19). Esto último podría relacionarse con el cambio en las prácticas de la profilaxis intraparto para evitar infecciones invasoras tempranas por SGB (7,19).…”

Section: Discussionunclassified

“…Las más frecuentes son causadas por Streptococcus agalactiae o Streptococcus del grupo B (SGB) y por Escherichia coli (7,8). Corresponde al obstetra la prevención del parto prematuro y de los resultados adversos perinatales en estos casos (9,10).…”

Section: Introductionunclassified

Meningitis Neonatal Precoz causada por transmisión vertical de Escherichia coli productora de beta-lactamasa de espectro extendido en parto prematuro con rotura prematura de membranas

Ovalle

García

Oda

et al. 2017

Rev. chil. obstet. ginecol.

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Epidemiology of Invasive Early-Onset Neonatal Sepsis, 2005 to 2014

Abstract: GBS prevention efforts have not led to an increasing burden of early-onset E coli infections. However, the stable burden of E coli sepsis and associated mortality underscore the need for interventions.

Cited by 365 publications

References 17 publications

Implementation of the Neonatal Sepsis Calculator in an Australian Tertiary Perinatal Centre

Implementation of the Neonatal Sepsis Calculator in an Australian Tertiary Perinatal Centre

Cardiac Function Affection in Infants with Neonatal Sepsis

Meningitis Neonatal Precoz causada por transmisión vertical de Escherichia coli productora de beta-lactamasa de espectro extendido en parto prematuro con rotura prematura de membranas

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