2010
DOI: 10.1128/aac.01077-09
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Epidemiology of Invasive Meningococcal Disease with Decreased Susceptibility to Penicillin in Ontario, Canada, 2000 to 2006

Abstract: Neisseria meningitidis has been relatively slow to acquire resistance to penicillin. We previously reported an increase in the incidence of invasive meningococcal disease (IMD) strains with decreased susceptibility to penicillin (

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Cited by 26 publications
(14 citation statements)
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“…In a previous study in Tunisia, 34% of the strains were MDSP (26). This is a high percentage of MDSP compared to that in French (34%) and Canadian (21.7%) studies (27,28). However, in Spain, the percentage of MDSP is higher (67%) (29).…”
Section: Discussionmentioning
confidence: 77%
“…In a previous study in Tunisia, 34% of the strains were MDSP (26). This is a high percentage of MDSP compared to that in French (34%) and Canadian (21.7%) studies (27,28). However, in Spain, the percentage of MDSP is higher (67%) (29).…”
Section: Discussionmentioning
confidence: 77%
“…In fact, antibiotic susceptibility results were reviewed after the whole genome sequencing data were analyzed. The observed decrease of susceptibility in recent isolates could result from bias in small sample size and/or genuinely decreased susceptibility to penicillin in Ontario, Canada (Brown et al 2001). Different penA sequences were found to be associated with the difference in susceptibility within these two pairs.…”
Section: Resultsmentioning
confidence: 99%
“…Moreover, meningococci with reduced susceptibility to penicillin G (penicillin intermediate [Pen i ]) have been described (3, 57). The Pen i phenotype is mainly due to the presence of five amino acid substitutions (F504L, A510V, I515V, G541N, and I566V) in the transpeptidase region of the penicillin-binding protein 2 (PBP2), encoded by the penA gene (810).…”
Section: Textmentioning
confidence: 99%