2020
DOI: 10.1093/cid/ciaa1065
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Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study

Abstract: Background In this study we evaluated the incidence of invasive pulmonary aspergillosis among intubated patients with critical coronavirus disease 2019 (COVID-19) and evaluated different case definitions of invasive aspergillosis. Methods Prospective, multicentre study on adult patients with microbiologically confirmed COVID-19 receiving mechanical ventilation. All included participants underwent screening protocol for invasi… Show more

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Cited by 405 publications
(666 citation statements)
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“…In a recent study, Wang et al [1] reported invasive pulmonary aspergillosis in patients with coronavirus disease 2019 (COVID-19), thus claiming for an early intervention with bronchoscopy and the importance of obtaining evidence of fungal microbiology in patients with severe/critical COVID-19. We fully agree on this point considering that invasive fungal infections (IFI), mostly invasive pulmonary aspergillosis, are increasingly reported in COVID-19 patients admitted in intensive care units (ICU); coronavirus-associated pulmonary aspergillosis (CAPA) was demonstrated to affect up to 30% of ventilated patients with COVID-19 [2]. Nevertheless, few issues should be addressed.…”
Section: And Gilles Lebouchermentioning
confidence: 55%
See 1 more Smart Citation
“…In a recent study, Wang et al [1] reported invasive pulmonary aspergillosis in patients with coronavirus disease 2019 (COVID-19), thus claiming for an early intervention with bronchoscopy and the importance of obtaining evidence of fungal microbiology in patients with severe/critical COVID-19. We fully agree on this point considering that invasive fungal infections (IFI), mostly invasive pulmonary aspergillosis, are increasingly reported in COVID-19 patients admitted in intensive care units (ICU); coronavirus-associated pulmonary aspergillosis (CAPA) was demonstrated to affect up to 30% of ventilated patients with COVID-19 [2]. Nevertheless, few issues should be addressed.…”
Section: And Gilles Lebouchermentioning
confidence: 55%
“…Questions remain if COVID-19 patients have a true invasive aspergillosis or are just colonized with Aspergillus in regards with serum galactomannan negativity [3]. Nevertheless, an independent association between CAPA and 30-day mortality was recently demonstrated using a multivariate logistic regression model among intubated patients [2], although a causal link remains to date unproven.…”
Section: And Gilles Lebouchermentioning
confidence: 99%
“…We recorded a high number of infections by fungi, and most importantly Aspergillus spp. A recent study [30] has shown an extremely high incidence of infection by Aspergillus spp. in COVID-19 patients hospitalised in the ICU.…”
Section: Discussionmentioning
confidence: 99%
“…Co-infections in Covid-19 and especially in the SARS-CoV-2/HIV patients should be widely investigated since correct treatment would contribute to a favorable outcome [2,3]. Moreover, fungal infections play an important role as opportunistic infections in HIV or Covid-19 patients, and possible co-infections in both populations should be considered, and appropriate screening tests performed [1,8].…”
Section: Discussionmentioning
confidence: 99%
“…Even more challenging is the diagnosis of fungal infections in patients with Covid-19, with most of the infections being associated with Candida and Aspergillus species [1,2]. Indeed, coronavirus-associated pulmonary aspergillosis (CAPA) is a concern in Covid-19 patients, occurring in 20-35% of patients with severe acute respiratory syndrome (SARS), mainly in those requiring admission to the intensive care unit (ICU) and mechanical ventilation [1,5,6]. Similarly, candidemia occurrs in 2.5% to 6.9% of Covid-19 patients in the ICU, mainly catheter-related infections and often with unfavorable outcomes [7,8].…”
Section: Introductionmentioning
confidence: 99%