Epidemiology of irritable bowel syndrome and its associated factors in Saudi undergraduate students

AlButaysh, Omar F; ALQuraini, Azam Abdulwahab; Almukhaitah, Abdulmohsen A; Alahmdi, Yasser M; Alharbi, Fahad M.

doi:10.4103/sjg.sjg_459_19

Cited by 35 publications

(61 citation statements)

References 23 publications

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“…The prevalence of IBS among the female university students was 10.1%, which is within the range reported in China (8.7%-31.3%) [12,18,25], yet lower than the range in other countries (20.5%-41.8%) [26,27]. The variations reported in the rate of the prevalence of IBS might due to differing diagnostic criteria, lack of knowledge about various crosscultural aspects of IBS, and geographical area.…”

Section: Discussionmentioning

confidence: 44%

“…In addition, we found that there was no significant difference in the prevalence of IBS among the three colleges. Students in the College of Medicine had a higher risk of developing functional bowel diseases compared with those in other colleges [2,26]. The lack of difference may be explained by the fact that all of the participants in this study were enrolled in medical-related departments despite being in different university colleges.…”

Section: Discussionmentioning

confidence: 81%

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Exploring Quality of Life, Stress, and Risk Factors Associated with Irritable Bowel Syndrome for Female University Students in Taiwan

Chen

Hung

Kao

et al. 2021

IJERPH

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Irritable bowel syndrome (IBS) is a common recurrent functional gastrointestinal disorder that impacts on patients physically and mentally. Studies on IBS have focused on adults, yet few studies have examined IBS among female university students. The aim of this study was to investigate the prevalence of IBS for female university students and its related factors. Using a cross-sectional study design, a total of 2520 female university students were recruited in southern Taiwan. The structured questionnaires, including the Rome III IBS diagnostic questionnaire, IBS symptom severity scale, Perceived Stress Scale, and World Health Organization Quality of Life BREF questionnaire (WHOQOL-BREF) were used for data collection. A total of 1894 female students complete the questionnaires. The response rate was 75.15%. The results indicated 193 female students with IBS and the prevalence of IBS was 10.1%. IBS female students had higher levels of stress and lower QOL than non-IBS female students. The risk factors for female university students developing IBS were dysmenorrhea, food avoidance, class absenteeism, and the lower physical domain of QOL. It is advised to consider these factors when providing students with counselling and relevant services in the expectation of alleviating their IBS symptoms, reducing the incidence rate of IBS, and further improving their QOL.

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Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 81%

Exploring Quality of Life, Stress, and Risk Factors Associated with Irritable Bowel Syndrome for Female University Students in Taiwan

Chen

Hung

Kao

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…Long-term follow-up reports about this kind of functional bowel disease are rare because IBS-D has the clinical feature of recurrent episodes. IBS-D has many triggers, of which diet and emotion stress show high inducibility of this disease [ 31 , 32 ]. So, we prolong the treatment period to 12 weeks in order to reduce symptom relapse and obtain better long-term efficacy.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Tong-Xie-Yao-Fang granule and its impact on whole transcriptome profiling in diarrhea-predominant irritable bowel syndrome patients: study protocol for a randomized controlled trial

Wang

Huang

Zhu

et al. 2020

Trials

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Background Irritable bowel syndrome (IBS) is one kind of common functional bowel disease with obscure pathogenesis, and exploration about whole transcriptome profiling in IBS-D is still negligible. Conventional medications have limited effects, which makes focus shifted to traditional Chinese medicine (TCM). Tong-Xie-Yao-Fang, as a classic herbal formula in TCM, is pretty effective and safe for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D), but the underlying therapeutic mechanism remains unknown. We aim to verify the efficacy and safety of TXYF granule (the formula particles mixed together) in IBS-D and elucidate the gene-level mechanism of IBS-D and therapeutic targets of TXYF granule based on whole transcriptome analysis. Methods/design This is a randomized, double-blind, and placebo-controlled clinical trial consisting of 2 weeks of run-in period, 12 weeks of treatment period, and 8 weeks of follow-up period. We will enroll 120 participants with IBS-D, who will be randomly assigned to the TXYF granule group and the placebo group, and recruit additional 10 healthy individuals as controls for mechanistic outcome. The two groups respectively take TXYF granule or placebo orally for treatment. The primary outcome is the response rate of IBS-Symptom Severity Score (IBS-SSS). The secondary outcomes include adequate relief (AR), IBS-Quality of Life Questionnaire (IBS-QOL), and long-term efficacy. Mechanistic outcome is the whole transcriptome profiling of the intestinal mucosae from IBS participants before and after the treatment and healthy individuals. Discussion This trial will prove the effectiveness and safety of TXYF granule with high-quality evidence and provide a penetrating and comprehensive perspective on the molecular mechanism of IBS-D by whole transcriptome analysis, which makes us pinpoint specific biomarkers of IBS-D and therapeutic targets of TXYF. Trial registration Chinese Clinical Trial Registry ChiCTR-IOR-1900021785. Registered on 9 March 2019

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“…Longterm follow-up reports about this kind of functional bowel disease are rare because IBS-D has the clinical feature of recurrent episodes. IBS-D has many triggers, of which diet and emotion stress show high inducibility of this disease (31,32). So, we prolong the treatment period to 12 weeks in order to reduce symptoms relapse and obtain better long-term e cacy.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Tong-Xie-Yao-Fang granule and its impact on whole transcriptome profiling in diarrhea-predominant irritable bowel syndrome patients: study protocol for a randomized controlled trial

Wang

Huang

Zhu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Irritable bowel syndrome (IBS) is one kind of common functional bowel disease with obscure pathogenesis and exploration about whole transcriptome profiling in IBS-D is still negligible. Conventional medications have limited effects, which makes focus shifted to traditional Chinese medicine (TCM). Tong-Xie-Yao-Fang, as a classic herbal formula in TCM, is pretty effective and safe for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D), but the underlying therapeutic mechanism remains unknown. We aim to verify the efficacy and safety of TXYF granule (the formula particles mixed together) in IBS-D and elucidate the gene-level mechanism of IBS-D and therapeutic targets of TXYF granule based on whole transcriptome analysis. Methods/design: This is a randomized, double-blind and placebo-controlled clinical trial consisting of 2 weeks run-in period, 12 weeks treatment period and 8 weeks follow-up period. We will enroll 120 participants with IBS-D, who will be randomly assigned to TXYF granule group and the placebo group and recruit additional 10 healthy individuals as controls for mechanistic outcome. The two groups respectively take TXYF granule or placebo orally for treatment. The primary outcome is the response rate of IBS-Symptom Severity Score (IBS-SSS). The secondary outcomes include adequate relief (AR), IBS-Quality of Life Questionnaire (IBS-QOL) and long-term efficacy. Mechanistic outcome is the whole transcriptome profiling of the intestinal mucosae from IBS participants before and after the treatment and healthy individuals. Discussion: This trial will prove the effectiveness and safety of TXYF granule with high-quality evidence and provide a penetrating and comprehensive perspective on the molecular mechanism of IBS-D by whole transcriptome analysis, which makes us pinpoint specific biomarkers of IBS-D and therapeutic targets of TXYF.

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Epidemiology of irritable bowel syndrome and its associated factors in Saudi undergraduate students

Cited by 35 publications

References 23 publications

Exploring Quality of Life, Stress, and Risk Factors Associated with Irritable Bowel Syndrome for Female University Students in Taiwan

Exploring Quality of Life, Stress, and Risk Factors Associated with Irritable Bowel Syndrome for Female University Students in Taiwan

Efficacy of Tong-Xie-Yao-Fang granule and its impact on whole transcriptome profiling in diarrhea-predominant irritable bowel syndrome patients: study protocol for a randomized controlled trial

Efficacy of Tong-Xie-Yao-Fang granule and its impact on whole transcriptome profiling in diarrhea-predominant irritable bowel syndrome patients: study protocol for a randomized controlled trial

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