Epidemiology of macrolide-resistant Mycoplasma pneumoniae by age distribution in Japan

Kawakami, Naoki; Namkoong, Ho; Saito, Fumitake; Ishizaki, Masami; Yamazaki, Masahiko; Mitamura, Keiko

doi:10.1016/j.jiac.2020.08.006

Cited by 12 publications

(8 citation statements)

References 19 publications

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“…This is consistent with the statistical results of most relevant studies. Most studies suggest that the predisposing age of MP is around 5 years old ( 21 , 22 ), and 5 years old is in the middle stage of 3–7 patients, which is in line with the research conclusions. In addition, the study also conducted a lot of analysis and exploration on the changes of inflammatory indicators of MP.…”

Section: Discussionsupporting

confidence: 82%

Clinical analysis of the epidemiology and changes in inflammatory indexes of Mycoplasma pneumonia in acute and recovery stage pediatric patients

Liu¹,

Chen²,

Yan³

2022

Transl Pediatr

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Background: As Mycoplasma pneumoniae pneumonia (MPP) is on the rise in children and adolescents, this work explored the clinical analysis of epidemiological and inflammatory changes in children with MPP during the acute and convalescent phases, and analyzed their relationship with clinical manifestations.Methods: One hundred and twenty MP patients (experimental group) and 100 healthy children (control group) were selected as the research objects. Enzyme-linked immunosorbent assay (ELISA) was used to detect the changes in tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10) and procalcitonin (PCT). Results:The proportion of children aged 3-7 years was significantly higher than that of other age groups (0-1, 1-3, and 7-14 years old) (P<0.05). The serum levels of TNF-α, IL-6, IL-8, IL-10, and PCT in children with MP were significantly higher than those in the control group (P<0.05). Changes in pulmonary fibrosis and serum and pleural fluid TNF-α, IL-6, IL-8, IL-10, and PCT concentrations on chest X-ray and computed tomography (CT) in children with MP with pleural effusion significantly higher than that in children without pulmonary fibrosis (P<0.05).Conclusions: MPP was more common in children aged 3-7 years. In addition, the changes of inflammatory markers TNF-α, IL-6, IL-8, IL-10, and PCT in serum and pleural effusion of children with MP were of great value for the diagnosis, treatment, and prognosis of the disease.

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Section: Discussionsupporting

confidence: 82%

Clinical analysis of the epidemiology and changes in inflammatory indexes of Mycoplasma pneumonia in acute and recovery stage pediatric patients

Liu¹,

Chen²,

Yan³

2022

Transl Pediatr

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“…The higher the MP-DNA load, the longer the retention time of MP in the respiratory tract. As a result, persistent damage will be caused to the bronchial mucosa, and the patients become less sensitive to drugs, weakening the efficacy and delaying rehabilitation [10,11]. In this study, it was found that in MPLI-positive group, the duration of disease, defervescence time, disappearance time of cough and expectoration, disappearance time of chest opacity and length of stay were all longer than those in MPLI-negative group, and the proportion of cases with extrapulmonary complications and the WBC count were higher than those in MPLI-negative group.…”

Section: Discussionmentioning

confidence: 99%

Significance of the determination of DNA load of drug-resistant mycoplasma pneumoniae and 23sRNA gene mutation locus in children

Zhu¹,

Song²,

Ji³

et al. 2023

Trop. J. Pharm Res

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Purpose: To determine the significance of the detection of Mycoplasma pneumoniae (MP)-DNA load and 23sRNA gene mutation locus in children with drug-resistant MP pneumonia. Methods: A total of 158 children with MP pneumonia received drug sensitivity tests. The patients were divided into resistance group and non-resistance group. The MP-DNA load index (MPLI) and mutation rate of 23sRNA gene at 2063 locus were assessed and compared between the two groups: the MPLI-negative group and the MPLI-positive group, based on whether MPLI was greater than 6.12. The association of MPLI of all the patients and the 23sRNA gene mutation at 2063 locus in the resistance group, as well as clinical indicators were analyzed. Results: The MPLI of the resistance group was lower than that of the non-resistance group. In the MPLI-positive group, the duration of disease, defervescence time, disappearance time of cough and expectoration, disappearance time of chest opacity, and length of stay were all longer than those of the MPLI-negative group, while the proportion of cases with extrapulmonary complications and the white blood cell (WBC) count were higher than those of the MPLI-negative group. The mutation rate of 23sRNA gene at 2063 locus in the resistance group was higher than that in non-resistance group (p < 0.05). The defervescence time, disappearance time of cough and expectoration, disappearance time of chest opacity and length of stay were longer in the mutation-positive group than those in the mutation-negative group (p < 0.05). Conclusion: The mutation rate of 23sRNA gene at 2063 locus is higher in children with drug-resistant MP pneumonia. Furthermore, low MPLI and 23sRNA gene mutations at 2063 locus are associated with the duration of disease, disappearance time of clinical symptoms and other clinical indicators.

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“…El uso excesivo de antibióticos macrólidos en Asia ha contribuido al aumento de la resistencia a los macrólidos por M. pneumoniae. En China, más del 85% de las neumonías pediátricas causadas por este agente son resistentes a los macrólidos (Kawakami, N. et al, 2021). Se calcula que la incidencia de la resistencia varía según la región, así como el período de tiempo y la situación epidemiológica inherente.…”

Section: Resistencia a Antibióticosunclassified

Neumonía atípica en pacientes pediátricos, resistencia al tratamiento

Rosero-Pérez,

Fiallos–Brito

2023

MQRInvestigar

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Introducción: La neumonía atípica en pacientes pediátricos representa un desafío clínico significativo, caracterizado por su presentación clínica insidiosa y patrones de resistencia al tratamiento convencional. Esta condición es causada típicamente por patógenos que no se identifican en las pruebas rutinarias para neumonía, incluyendo Mycoplasma pneumoniae, Chlamydophila pneumoniae y Legionella spp. Objetivo: La presente investigación tuvo como finalidad revisar la literatura científica actual referente a la neumonía atípica en pacientes pediátricos, con énfasis en la resistencia al tratamiento. Metodología: Se efectuó un estudio bibliográfico minucioso en repositorios de datos como PubMed, Scopus y Google Scholar, utilizando palabras clave como “neumonía atípica pediátrica”, “resistencia antibiótica” y “tratamiento”. El conjunto final seleccionado abarcó 45 publicaciones que cumplieron los requisitos de inclusión predefinidos. Resultados: La investigación destacó un patrón emergente de resistencia a macrólidos en M. pneumoniae, con tasas que varían geográficamente. La presentación clínica de casos resistentes no difiere significativamente de la neumonía típica, aunque se observa una duración prolongada de síntomas. Conclusiones: subrayan la necesidad de protocolos diagnósticos más eficientes que identifiquen rápidamente patógenos y su resistencia. Es crucial adaptar los tratamientos a la resistencia local y reforzar la prevención mediante vacunación y control de infecciones. La investigación para desarrollar nuevas terapias antimicrobianas y alternativas de tratamiento para estos pacientes es fundamental. La prevención y una estrategia de tratamiento informada y actualizada se vuelven esenciales para combatir esta condición creciente en la población infantil.

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Epidemiology of macrolide-resistant Mycoplasma pneumoniae by age distribution in Japan

Cited by 12 publications

References 19 publications

Clinical analysis of the epidemiology and changes in inflammatory indexes of Mycoplasma pneumonia in acute and recovery stage pediatric patients

Clinical analysis of the epidemiology and changes in inflammatory indexes of Mycoplasma pneumonia in acute and recovery stage pediatric patients

Significance of the determination of DNA load of drug-resistant mycoplasma pneumoniae and 23sRNA gene mutation locus in children

Neumonía atípica en pacientes pediátricos, resistencia al tratamiento

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