Epidemiology of Malignant Cervical, Corpus Uteri and Ovarian Tumours - Current Data and Epidemiological Trends

Abstract

Introduction !In addition to breast cancer, gynaecological malignancies also include cervical, endometrial and ovarian cancers. Cancer of the corpus uteri is the most common malignancy of the female genital tract, followed by ovarian and cervical cancer.In Germany, these malignancies account respectively for 5.1 % (fourth most common malignancy in women), 3.5 % (sixth most common) and 2.2 % (twelfth most common) of all newly diagnosed cancers in women. As most cervical and endometrial cancers, particularly oestrogen-dependent endometrial tumours, are diagnosed at an early Abstract ! Cervical, uterine and ovarian cancers are the most common malignancies of the female genital tract. Using current data from population-based cancer registries in Germany, we present the recent figures for the incidence, prevalence, associated mortality and survival for these cancers. In 2009, a total of 23 800 women were newly diagnosed with one of the three gynaecological cancers (cervical cancer: 20.3 %, endometrial cancer: 48.5 %, ovarian cancer: 31.2 %). This figure equals approximately one third of the number of women newly diagnosed with breast cancer in the same year. The relative 5-year survival for carcinomas of the corpus uteri is 79 % and is higher that those for cervical cancer (68 %) and ovarian cancer (40 %). Ovarian cancer in particular is often diagnosed at a later stage and has a high risk of recurrence. Due to the favourable prognosis for endometrial tumours and the unfavourable prognosis for ovarian malignancies, the incidence of various gynaecological tumours is ranked differently compared to the 5-year prevalence of these same tumours. Currently, the 5-year prevalence in Germany for patients with cervical, endometrial or ovarian cancer is estimated to be around 80 000 women. Slightly more than half of these women were diagnosed with cancer of the corpus uteri. Around 25 % of women have ovarian and 21% have cervical cancer. Zusammenfassung

Incidence and mortality rates in breast, corpus uteri, and ovarian cancers in Poland (1980–2013): an analysis of population-based data in relation to socio-economic changes

“…Similar results were found by Waldmann et al, who reported a decrease in incidence and mortality of OC among a German population during the last two decades. 34 Another study reported stable OC incidence and mortality rates in Nordic countries for 1964–2003. 35 Interestingly, despite the decreasing fertility rate and parity, we observed a decrease in the OC incidence in the analyzed population.…”

Comparing PI3K/Akt Inhibitors Used in Ovarian Cancer Treatment

“…Epithelial ovarian carcinoma (EOC) is the most lethal gynecological malignancy (Siegel et al, 2012). Most patients with EOC are diagnosed at an advanced stage and although most initially respond to cytoreductive surgery and platinum-based chemotherapies, many EOC patients eventually relapse, develop chemoresistant tumors, and die because of the disease (Ozols, 2006;Waldmann et al, 2013). As the empirical incorporation of additional cytotoxic agents against ovarian cancer does not improve prognosis (Bookman et al, 2009), understanding the key signaling pathway responsible for chemoresistance and disease progression is required to develop new treatment strategies.…”

Endometriosis as a risk factor for ovarian or endometrial cancer — results of a hospital-based case–control study

“…About 14,000 of these women are expected to die of the disease [ 1 ]. In Germany the corresponding figures are 7400 and 5500 [ 2 ]. This high mortality rate is mainly the consequence of ineffective early detection or screening programs.…”