Epidemiology of Methicillin-Resistant Staphylococcus aureus at a Pediatric Healthcare System, 1991–2003

Jungk, Jessica; Como‐Sabetti, Kathryn; Stinchfield, Patricia; Ackerman, Patricia; Harriman, Kathleen

doi:10.1097/01.inf.0000257452.58182.e1

Cited by 29 publications

(22 citation statements)

References 31 publications

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“…CA-MRSA invasive infections in pediatric patients appear to follow an increasing trend of publications worldwide [8,9,12,18,25]. Pediatricians should be alert that empirical therapy with antistaphylococcal β-lactams may be insufficient in CA-MRSA infections.…”

Section: Discussionmentioning

confidence: 97%

“…Invasive infections due to community-acquired methicillinresistant Staphylococcus aureus (CA-MRSA) have been increasingly reported [18,41]. Αll these isolates harbor SCCmec type IV that confers resistance to β-lactam antistaphylococcal antibiotics and possess Panton-Valentine leukocidin (PVL) gene that has been associated with necrotizing pneumonia and aggressive soft tissue infections [12,15,17,31].…”

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confidence: 99%

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Life-threatening infection due to community-acquired methicillin-resistant Staphylococcus aureus: case report and review

et al. 2009

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We report an unusual case of serious, multifocal, invasive infection due to community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in a 10-year-old girl with favorable outcome. The child manifested femoral osteomyelitis, pyomyositis, deep femoral vein thrombosis, pneumonia, encephalopathy, and disturbances of almost all organs. She remained in a critical condition for a week. Fever persisted for 6 weeks and acute phase reactants remained increased for 6 months, necessitating a 7-month antistaphylococcal therapy with a glycopeptide and clindamycin. This led to resolution of infection-associated problems during the subsequent 36 months of follow-up. CA-MRSA strain isolated from the patient harbored both staphylococcal chromosomal cassette type IV (SCCmec type IV) and Panton-Valentine leukocidin genes. A literature review of serious CA-MRSA infections indicated that only a small minority of published cases had favorable outcome.

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Life-threatening infection due to community-acquired methicillin-resistant Staphylococcus aureus: case report and review

et al. 2009

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“…Over the past decade, CA-MRSA infection has become a quickly growing problem in pediatric hospitals [29,31]. As there is no definite consensus about why otherwise healthy children acquire these resistant bacteria, we decided to evaluate the clinical and microbiological characteristics of CA-MRSA isolates recovered from 138 consecutive patients with SSTIs.…”

Section: Discussionmentioning

confidence: 99%

Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina

Specht

Gardella

Úbeda

et al. 2014

J Infect Dev Ctries

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Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) emerged at the Pediatric Hospital of Misiones Province, north Argentina, in 2003 as a cause of community-acquired (CA) infections, mostly associated with skin and soft tissue infections (SSTIs). This study aimed to assess the microbiological, epidemiological, and clinical features of CA-MRSA SSTIs treated at the hospital. Methodology: From 2003 through 2006, a longitudinal study on CA-MRSA SSTIs was conducted. Clinical, bacteriological, and molecular data were collected and analyzed by multiple correspondences and cluster analysis (MCCA). Results: A total of 138 children were enrolled; 55.8% of the children required hospitalization. The main clinical presentation was abscesses (51%). Antibiotic therapy in the previous six months was registered in 41% of the patients, and 72% of the patients had relatives with similar symptoms. Resistance to non--lactam antibiotics was found in less than 12% of patients. All 44 isolates carried staphylococcal cassette chromosomemec (SCCmec) type IV, and 30/44 had Panton-Valentine leucocidin (PVL) coding genes. Six pulsed-field gel electrophoresis (PFGE) patterns were detected from 17 isolates. MCCA hierarchic classification resulted in four distinctive patient classes (new variable). No relationship could be observed regarding the PVL detection, as PVL (+) isolates were detected in all classes; the same lack of significance was observed concerning the distribution of resistance to non-β-lactam antibiotics. Conclusions: This study increases the understanding and knowledge about CA-MRSA skin and soft tissue infections in pediatric patients. Continuous efforts should be made to control this significant public health problem.

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“…There have also been cases of infection caused by CA-MRSA strains acquired in connection with staying in hospital 52 . In 2007 a paper was published reporting that with the help of retrospective investigation of S. aureus strain isolates from 1991-2003, there were identifi ed MRSA strains with a CA-MRSA pattern at a child clinic already in 1991 20 .…”

Section: Current Knowledge Of Methicillin-resistant Staphylococcus Aumentioning

confidence: 99%

“…From that time MRSA was considered to be the most important agent of hospital infections, both in adult and child patients 20 .…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

Current Knowledge of Methicillin-Resistant Staphylococcus Aureus and Community-Associated Methicillin-Resistant Staphylococcus Aureus

Matousková¹,

Janout²

2008

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background: Bacterial strains that are oxacillin and methicillin-resistant, historically termed methicillin-resistant Staphylococcus aureus (MRSA) are resistant to all ß-lactam agents, including cephalosporins and carbapenems. MRSA are pathogenic and have a number of virulence factors that enable them to result in disease. They are transmissible and important causes of nosocomial infections worldwide. An MRSA outbreak can occur when one strain is transmitted to other patients or through close contacts of infected persons in the community. Hospital-associated MRSA (HA-MRSA) isolates are also frequent causes of healthcare-associated bloodstream and catheter-related infections. Community-associated MRSA (CA-MRSA) isolates are often only resistant to beta-lactam agents and erythromycin but they are an emerging cause of community-associated infections, ecpecially skin and soft tissue infections (SSTI) and necrotizing pneumonia.Methods: Current possibilities for detecting MRSA strains in the laboratory are reviewed and discussed in the context of the recent literature.Results and Conclusion: The active surveillance and prevention of MRSA occurence and spreading in hospitals are discussed in the context of recent literature.

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Epidemiology of Methicillin-Resistant Staphylococcus aureus at a Pediatric Healthcare System, 1991–2003

Abstract: CA-MRSA is well established in this pediatric population. Although no discernable changes in CA- or HA-MRSA case characteristics were documented during the study period, significant changes were observed in CA-MRSA isolate characteristics, indicating that this pathogen continues to evolve.

Cited by 29 publications

References 31 publications

Life-threatening infection due to community-acquired methicillin-resistant Staphylococcus aureus: case report and review

Life-threatening infection due to community-acquired methicillin-resistant Staphylococcus aureus: case report and review

Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina

Current Knowledge of Methicillin-Resistant Staphylococcus Aureus and Community-Associated Methicillin-Resistant Staphylococcus Aureus

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