Epidemiology of mixed Schistosoma mansoni and Schistosoma haematobium infections in northern Senegal

Meurs, Lynn; Mbow, Moustapha; Vereecken, Katleen; Menten, Joris; Mboup, Souleymane; Polman, Katja

doi:10.1016/j.ijpara.2012.02.002

Cited by 64 publications

(88 citation statements)

References 53 publications

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“…S. mansoni prevalences were 16% in Pakh, 75% in Ndieumeul and 55% in Diokhor. Schistosoma haematobium was co-endemic in all the villages (57% in Pakh, 66% in Ndieumeul and 44% in Diokhor) with mixed infection prevalences of 12% in Pakh, 55% in Ndieumeul and 32% in Diokhor (Meurs et al, 2012;unpublished data).…”

Section: Description Of the Study Sites And Epidemiologymentioning

confidence: 93%

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Inbreeding within human Schistosoma mansoni: do host-specific factors shape the genetic composition of parasite populations?

et al. 2014

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The size, structure and distribution of host populations are key determinants of the genetic composition of parasite populations. Despite the evolutionary and epidemiological merits, there has been little consideration of how host heterogeneities affect the evolutionary trajectories of parasite populations. We assessed the genetic composition of natural populations of the parasite Schistosoma mansoni in northern Senegal. A total of 1346 parasites were collected from 14 snail and 57 human hosts within three villages and individually genotyped using nine microsatellite markers. Human host demographic parameters (age, gender and village of residence) and co-infection with Schistosoma haematobium were documented, and S. mansoni infection intensities were quantified. F-statistics and clustering analyses revealed a random distribution (panmixia) of parasite genetic variation among villages and hosts, confirming the concept of human hosts as 'genetic mixing bowls' for schistosomes. Host gender and village of residence did not show any association with parasite genetics. Host age, however, was significantly correlated with parasite inbreeding and heterozygosity, with children being more infected by related parasites than adults. The patterns may be explained by (1) genotype-dependent 'concomitant immunity' that leads to selective recruitment of genetically unrelated worms with host age, and/or (2) the 'genetic mixing bowl' hypothesis, where older hosts have been exposed to a wider variety of parasite strains than children. The present study suggests that host-specific factors may shape the genetic composition of schistosome populations, revealing important insights into host-parasite interactions within a natural system.

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Section: Description Of the Study Sites And Epidemiologymentioning

confidence: 93%

“…The prevalences and intensities of S. mansoni infection increased up to the second decade of life, with a subsequent decrease in adults (Meurs et al, 2012). S. mansoni prevalences were 16% in Pakh, 75% in Ndieumeul and 55% in Diokhor.…”

Section: Description Of the Study Sites And Epidemiologymentioning

confidence: 98%

Inbreeding within human Schistosoma mansoni: do host-specific factors shape the genetic composition of parasite populations?

et al. 2014

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“…6 Children aged between 5 and 15 years have a higher infection rate, with a consequent reduction in the adult population. 3,[7][8][9][10] The reported risk of infection was higher in women, 5 but in other studies, 11,12 male children were more likely to be infected than female children were. [8][9][10] Socio-economic status, level of education, and untreated water and sanitation were associated with transmission of the pathogens.…”

Section: Introductionmentioning

confidence: 89%

“…3,4 The prevalence in the north of Senegal was 61% for S. mansoni and 50% for S. haematobium. 5 For urinary schistosomiasis, the reported prevalence among children aged 7 to 15 years was 57.6%. 6 Children aged between 5 and 15 years have a higher infection rate, with a consequent reduction in the adult population.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitudes, and Practices Related to Schistosomiasis Among Children in Northern Senegal

Frigerio

Bert

Clari

et al. 2017

Annals of Global Health

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Background: Schistosomiasis is a highly prevalent parasitic disease in Senegal. The early symptoms are haematuria and dysuria. Children's comprehension of the disease is fundamental to preventing the infection. The aim of this study was to investigate the knowledge, attitude and practices related to schistosomiasis among school children of two rural villages in North Senegal. Methods:A cross-sectional study was conducted. Data about children's knowledge of schistosomiasis, behaviour and preventive measures were collected through a questionnaire.Results: Questionnaire responses from 575 school children were analysed. Correct answers about risky behaviour for schistosomiasis were associated with early symptoms (p=0.010).Wearing shoes and washing hands with soap were associated with not having haematuria and dysuria (p=0.007 and 0.049 respectively). Playing in rivers was associated with the abovementioned symptoms (p<0.001). Children who had good knowledge of schistosomiasis reportedly did not have symptoms (p=0.002). A logistic regression model showed that being a female (OR=0.35; p=0.01) or attending a primary school (OR=0.13; p<0.001) were significant predictors of a lower risk of the early symptoms of urinary schistosomiasis.Conclusion: This study revealed that the level of knowledge among children in North Senegal about the cause, transmission, prevention and treatment of schistosomiasis warrants implementing educational intervention.

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“…7,8 To fight against this pathology, Senegal, in agreement and in partnership with the WHO (who provided praziquantel), implemented a national control program against schistosomiasis called "Programme National de Lutte contre les Bilharzioses" (PNLB) in 1999. However, some parts of the country in eastern Senegal are really difficult to reach.…”

Section: Introductionmentioning

confidence: 99%

Schistosomiasis Sustained Control Program in Ethnic Groups Around Ninefescha (Eastern Senegal)

N’Diaye¹,

Dioukhane²,

Ndao³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Epidemiology of mixed Schistosoma mansoni and Schistosoma haematobium infections in northern Senegal

Cited by 64 publications

References 53 publications

Inbreeding within human Schistosoma mansoni: do host-specific factors shape the genetic composition of parasite populations?

Inbreeding within human Schistosoma mansoni: do host-specific factors shape the genetic composition of parasite populations?

Knowledge, Attitudes, and Practices Related to Schistosomiasis Among Children in Northern Senegal

Schistosomiasis Sustained Control Program in Ethnic Groups Around Ninefescha (Eastern Senegal)

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