Epidemiology of Multiple Myeloma and Related Plasma Cell Disorders: An Analytic Review

Blattner, William A.

doi:10.1016/b978-0-444-00377-5.50006-6

Cited by 31 publications

(18 citation statements)

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“…Familial occurrence of myeloma has been reported in spouses (Kyle et al, 1976) and in blood relatives (Maldonado & Kyle 1974). Other suspected risk factors are summarized in the excellent review of Blattner, (1980).…”

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confidence: 99%

Allergies and agricultural exposure as risk factors for multiple myeloma

Gallagher¹,

Spinelli²,

Elwood³

et al. 1983

Br J Cancer

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Summary In a case-control study of 84 multiple myeloma patients and 168 age-and sex-matched controls with tumours at other sites, reported prior allergies were associated with an elevated risk of myeloma (RR = 3.1, P<0.001). In addition, more myeloma patients than controls reported prior myxoedema (RR= 5.0 Incidence rates for multiple myeloma in British Columbia are 3.4 and 2.2 per 100,000 in males and females respectively (B.C. Ministry of Health, 1976). A recent study has indicated that the incidence has been increasing over the last 30 years (Velez et al., 1983). The highest reported incidence in the world is in U.S. black males (Waterhouse et al., 1976). Several occupational risks have been demonstrated, with Milham showing elevated mortality for myeloma among farmers, woodworkers, smeltermen and forgemen (Milham, 1976). Several studies have shown nuclear workers to be at high risk for myeloma (Dolphin, 1976;Lewis, 1963;Cuzick, 1981).Schafer and Miller in a study of 153 patients showed elevated risks of prior biliary disease and peptic ulcer in patients with IgA myeloma when compared to patients with all other myeloma types (Schafer & Miller 1979), and Allen found an elevated frequency among myeloma patients of individuals with group A blood (Allen, 1970). Familial occurrence of myeloma has been reported in spouses (Kyle et al., 1976) and in blood relatives (Maldonado & Kyle 1974 C) The

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confidence: 99%

Allergies and agricultural exposure as risk factors for multiple myeloma

Gallagher¹,

Spinelli²,

Elwood³

et al. 1983

Br J Cancer

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“…Higher rates of MM in U.S. black vs. white populations and in some parts of Africa have been confirmed (Blattner et al, 1979(Blattner et al, , 1981Blattner, 1980Blattner, , 1982Waterhouse et al, 1982). The explanation for the twofold-orgreater incidence of MM among some black (i.e., US., Jamaican, and South African) vs. white populations (Table 1) is unknown; both genetic susceptibility and environmental antigenic exposures have been proposesd (Blattner, et al, 1979;Blattner, 1980Blattner, , 1982.…”

Section: Multiple Myelomamentioning

confidence: 78%

Connective tissue responses in blacks in relation to disease: Further observations

Polednak¹

1987

American J Phys Anthropol

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Additional information is presented in support of the hypothesis (Polednak: Am. J. Phys. Anthropol. 41:49-58, 1974) that in some black populations certain connective-tissue responses, which are involved in protection against infection and repair after injury, also may predispose to specific chronic diseases. These diseases include some autoimmune disorders (i.e., systemic lupus erythematosus, sarcoidosis, and scleroderma) and various benign and malignant tumors involving connective-tissue cells. Complex interactions between genetic factors (HLA and non-HLA loci) and environmental agents may be involved both in the etiology of these autoimmune diseases and in population differences in the incidence of these diseases. A framework is reviewed whereby cellular responses to infectious agents, involving chiefly immunoglobulin-producing cells and macrophages, may have consequences in terms of pathogenesis of specific chronic diseases more common in some black populations. The possible role of natural selection in maintaining some of these diseases is also considered, along with the need for involvement of biomedical anthropologists in their investigation.

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“…drugs) factors arc discussed in the etiol ogy of multiple myeloma [1], A review of the literature indicates the acceptance that chronic infections could lead to a local plas mocyte infiltration which may be followed by a malignant transformation [1][2][3][4][5]. To the best of our knowledge there is no published report of a myeloma in patients with chronic pyelonephritis and dialysis treatment.…”

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confidence: 93%

“…The reported 2 cases arc 0.66% of 302 patients with CRF on hemodialysis for a period of 18 years. Thus the risk of develop ment of myeloma among patients on dialysis is about 100 limes higher compared to the rest of the population where the frequency is 1-4/100,000 (1], The evolution of the 'secondary' myelo ma differs from the evolution of satellite myeloma nephropathy, as the latter gives an opportunity for outliving 5 years in cases where combination of chemotherapy and he modialysis is instituted [6]. Patients with CRF and maintenance hemodialysis are at high risk of malignant processes [6], The reported 2 cases support this thesis [7].…”

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confidence: 99%