Epidemiology of Nasopharyngeal Lymphoma in the United States: A Population‐Based Analysis of 1119 Cases

Han, Albert Y; Kuan, Edward C.; Alonso, José Eugenio Lozano; Badran, Karam W.; John, Maie A. St.

doi:10.1177/0194599817695808

Cited by 23 publications

(37 citation statements)

References 40 publications

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“…systemic TCL vs. nasal type NK/T cell lymphoma, was provided. Additionally, this fairly large SEER data showed a significantly short overall survival (OS) in NK/T cell lymphoma (13.6 months) (12). The median OS in our study was 36 months, ranging from 4 to 125 months.…”

Section: Discussionsupporting

confidence: 43%

“…One partial, n/a not available study described 62 cases of non-Hodgkin lymphoma of the head and neck region; the majority of which were B cell lymphomas (52 out of 62) with only 7 patients with diagnosis of TCL, including cutaneous forms [11]. Another study focusing on nasopharyngeal lymphoma in 1,119 cases, reported NK/T cell lymphoma comprising only 6% (n = 67) of the cases [12]. However no further sub classification of the TCL, i.e.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Systemic Non-Hodgkin T Cell Lymphomas Presenting in the Head and Neck Region: An Institutional Experience of a Rare Entity

Broadwater

Peker

2018

Head and Neck Pathol

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T cell lymphoma (TCL) is a group of rare and aggressive diseases. TCL primary to head and neck organs often present as extranodal NK/T cell lymphoma, nasal type. Systemic TCL with initial head and neck presentation is extremely rare. Here we report our institutional experience. Clinicopathologic data was collected from patients diagnosed with TCL and treated at the University of Alabama at Birmingham between 2002 and 2012. Eleven cases of systemic TCL initially presented at head and neck region were identified. The median age was 54 years and male:female ratio was 1.8. The most common sites involved were sinonasal tissue, tonsil, tongue and larynx. Most patients presented with a mass lesion without systemic symptoms. The presentation of TCL primary to the head and neck region is often non-specific. A misdiagnosis of undifferentiated tumor or chronic inflammation due to ambiguous morphology is not uncommon. TCL should be considered in differential diagnosis and a thorough evaluation is warranted for accurate diagnosis.

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Section: Discussionsupporting

confidence: 43%

Section: Discussionmentioning

confidence: 99%

Systemic Non-Hodgkin T Cell Lymphomas Presenting in the Head and Neck Region: An Institutional Experience of a Rare Entity

Broadwater

Peker

2018

Head and Neck Pathol

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“…WR is not included in the anatomical classification of cervical lymph levels, and is often referred to as an extranodal site of lymphoid tissue. WR is considered the most common extranodal site in the head and neck region in NHL 2,3 . In the pediatric population, WR involvement in NHL is also well described 1,4,5 ; however, involvement of WR in Hodgkin lymphoma (HL) is extremely rare, and is reported almost exclusively in the adult population 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Expert consensus statements for Waldeyer's ring involvement in pediatric Hodgkin lymphoma: The staging, evaluation, and response criteria harmonization (SEARCH) for childhood, adolescent, and young adult Hodgkin lymphoma (CAYAHL) group

Seelisch

Alarcón

Flerlage

et al. 2020

Pediatric Blood & Cancer

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Waldeyer's ring (WR) involvement in pediatric Hodgkin lymphoma (HL) is extremely rare and criteria for determining involvement and response to treatment are unclear. The international Staging, Evaluation, and Response Criteria Harmonization for Childhood, Adolescent and Young Adult Hodgkin Lymphoma (SEARCH for CAYAHL) Group performed a systematic review of the literature in search of involvement or response criteria, or evidence to support specific criteria. Only 166 cases of HL with WR involvement were reported in the literature, 7 of which were pediatric. To date no standardized diagnostic or response assessment criteria are available. Given the paucity of evidence, using a modified Delphi survey technique, expert consensus statements were developed by the SEARCH group to allow for a more consistent definition of disease and response evaluation related to this rare site of involvement among pediatric oncologists. The available evidence and expert consensus statements are summarized.

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“…Lymphoma, the most common non-epithelial malignancy of the head and neck region, can be classified into two types, Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL) [1]. Among them, primary nasopharyngeal (NP) lymphoma is a very rare tumor, with only limited studies found in the literatures [2,3,4,5,6,7,8,9,10]. Waldeyer-Hartz firstly described the lymphoid tissues within the nasopharynx, oropharyngeal wall, base of the tongue, palatine tonsils, and soft palate, known today as Waldeyer’s ring (WR) [7].…”

Section: Introductionmentioning

confidence: 99%

Nasopharyngeal Lymphoma: A 22-Year Review of 35 Cases

Hsueh

Yang

Gau

et al. 2019

JCM

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Nasopharyngeal (NP) lymphoma is a rare primary malignancy of the head and neck and represents a minority of malignancies originating from the nasopharynx. For this reason, there are limited data regarding epidemiologic and treatment outcomes. This is a retrospective review of patients diagnosed with NP lymphoma from 1995 to 2017 at a tertiary medical center. The patients’ demographic data, clinical presentations, treatment modalities, Epstein–Barr virus (EBV)-encoded small RNA (EBER) staining, and outcomes were investigated. We considered a total of 35 patients, including 20 males and 15 females, diagnosed with NP lymphoma. The age ranged from 17 to 88 years (mean = 59.6). The common presentations were nasal obstruction, epistaxis, and neck mass. In our study, the most common pathological diagnosis of NP lymphoma was diffuse large B cell lymphoma (DLBCL) (n = 17), followed by NK/T cell lymphoma (NKTCL) (n = 9). Other pathologic diagnoses included extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALToma), small lymphocytic lymphoma, mantle cell lymphoma. There were 13 cases showing EBER positivity, including 7 cases of NKTCL, 5 cases of DLBCL, and 1 case of post-transplant lymphoproliferative disorder (PTLD). Most patients received chemotherapy alone, while some patients received both chemotherapy and radiotherapy. Seven patients had local recurrence, and fewer than half of the patients (n = 16) were alive at the time of the study (mean follow-up duration: 54.4 months). The five-year overall survival was 50.4%. NP lymphoma is very rare, and the most common pathologic type is DLBCL. EBER positivity is found in both NKTCL and DLBCL. Identifying more effective therapeutic agents is extremely important to improve patients’ survival.

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Epidemiology of Nasopharyngeal Lymphoma in the United States: A Population‐Based Analysis of 1119 Cases

Cited by 23 publications

References 40 publications

Systemic Non-Hodgkin T Cell Lymphomas Presenting in the Head and Neck Region: An Institutional Experience of a Rare Entity

Systemic Non-Hodgkin T Cell Lymphomas Presenting in the Head and Neck Region: An Institutional Experience of a Rare Entity

Expert consensus statements for Waldeyer's ring involvement in pediatric Hodgkin lymphoma: The staging, evaluation, and response criteria harmonization (SEARCH) for childhood, adolescent, and young adult Hodgkin lymphoma (CAYAHL) group

Nasopharyngeal Lymphoma: A 22-Year Review of 35 Cases

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