Epidemiology of Neonatal Necrotizing Enterocolitis in the Post-Surfactant Era:A Population-Based Study

Llanos, Adolfo; Moss, Mark E.; Pinzon, Maria C Mora; Shultz, Jaci M; Kendig, James W.

doi:10.1203/00006450-199904020-01480

Cited by 12 publications

(29 citation statements)

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“…In North American studies, non-Hispanic black infants were at an increased risk [2,17,18]. Maternal risk factors identified included prolonged rupture of membranes, hemorrhage, and cesarean delivery [18].…”

Section: Discussionmentioning

confidence: 99%

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National prospective surveillance study of necrotizing enterocolitis in neonatal intensive care units

Rees

Eaton

Pierro

2010

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 99%

“…It is well-known that NEC is associated with prematurity and particularly with extremely low birth weight [1][2][3]. Necrotizing enterocolitis is rare in term infants [4], in whom it is usually associated with congenital anomalies, sepsis, or hypotension [5].…”

mentioning

confidence: 99%

National prospective surveillance study of necrotizing enterocolitis in neonatal intensive care units

Rees

Eaton

Pierro

2010

Journal of Pediatric Surgery

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“…1,2 In the early stages of the disease, the clinical presentation is often rather nonspecific. Diagnostic tests and therapeutic management are thus often based on the experience of the physician involved, and there is great variation in the clinical, radiological and laboratory evaluation.…”

Section: Introductionmentioning

confidence: 99%

A simple presurgical necrotizing enterocolitis-mortality scoring system

et al. 2006

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Objective: To assess the relationship between early laboratory parameters, disease severity, type of management (surgical or conservative) and outcome in necrotizing enterocolitis (NEC). Study design:Retrospective collection and analysis of data from infants treated in a single tertiary care center (1980 to 2002). Data were collected on disease severity (Bell stage), birth weight (BW), gestational age (GA) and pre-intervention laboratory parameters (leukocyte and platelet counts, hemoglobin, lactate, C-reactive protein).Results: Data from 128 infants were sufficient for analysis. Factors significantly associated with survival were Bell stage (P<0.05), lactate (P<0.05), BW and GA (P<0.01, P<0.001, respectively). From receiver operating characteristics curves, the highest predictive value resulted from a score with 0 to 8 points combining BW, Bell stage, lactate and platelet count (P<0.001). At a cutoff level of 4.5 sensitivity and specificity for predicting survival were 0.71 and 0.72, respectively.Conclusion: Some single parameters were associated with poor outcome in NEC. Optimal risk stratification was achieved by combining several parameters in a score.

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“…23 enteral feeding NEC predominantly occurs in babies who have been enterally fed, 24 although it has occasionally been reported in completely unfed babies. 25,26 Feeding with formula milk appears to increase the risk of NEC, whereas breast milk has a protective effect. 27,28 The timing of initiation and speed of increase of enteral feeds is a subject of much debate.…”

Section: Bacterial Colonizationmentioning

confidence: 99%

Necrotizing enterocolitis: current perspectives

Yajamanyam

Rasiah²,

Ewer³

2014

RRN

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Necrotizing enterocolitis is the most common gastrointestinal emergency in neonates, particularly in those born very preterm. It is a leading cause of morbidity and mortality, especially in extremely low birth weight infants. Despite extensive research, the pathophysiology of necrotizing enterocolitis remains unclear and therapeutic options are limited. Multiple risk factors have been reported, but most are associated with prematurity and its complications. This makes management very challenging in vulnerable preterm infants. In this review, we focus on the risk factors and some of the current research in this area, particularly studies aimed at early detection and potential preventive measures for this potentially lethal condition.

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Epidemiology of Neonatal Necrotizing Enterocolitis in the Post-Surfactant Era:A Population-Based Study

Cited by 12 publications

References 0 publications

National prospective surveillance study of necrotizing enterocolitis in neonatal intensive care units

National prospective surveillance study of necrotizing enterocolitis in neonatal intensive care units

A simple presurgical necrotizing enterocolitis-mortality scoring system

Necrotizing enterocolitis: current perspectives

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