Epidemiology of neurodegenerative diseases in the East African region: A meta-analysis

Onohuean, Hope; Akiyode, Abraham Olutumininu; Akiyode, Oluwole Olusegun; Igbinoba, Sharon Iyobor; Alagbonsi, Isiaka Abdullateef

doi:10.3389/fneur.2022.1024004

Cited by 18 publications

(9 citation statements)

References 94 publications

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“…We limited the search to peer-reviewed articles that were published in the English language. The paper selection process followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 guideline [ 4 , 14 ].…”

Section: Methodsmentioning

confidence: 99%

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UCP-LF and other assay methods for schistosome circulating anodic antigen between 1978 and 2022

Fasogbon

Aja

Ondari

et al. 2023

Biology Methods and Protocols

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Background Detection of circulating anodic antigen (CAA) is known for its high sensitivity in diagnosing schistosomiasis infection, even in low-prevalence settings. The Up-Converting Phosphor-Lateral Flow (UCP-LF) assay developed in 2008 presented greater sensitivity than other assay methods in use for CAA detection. Aim Our study aims to comprehensively review all studies conducted in this area and thus generate informed conclusions on the potential for adopting the UCP-LF assay for diagnosing this important yet neglected tropical disease. Method Using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, we generated search criteria to capture all studies in English journals available in the Scopus and PubMed databases on 20th December 2022. Result A total of 219 articles were identified, and 84 that met the inclusion criteria were retrieved and eventually included in the study. Twelve different assay methods were identified with a noteworthy transition from Enzyme Linked Immuno-Sorbent Assay (ELISA) to the UCP-LF assay, a laboratory-based assay that may be applicable as a point-of-care (POC) diagnostic test for schistosomiasis. Recommendation Reducing the time, cost and dependence on specialized laboratory skills and equipment, especially relating to the trichloroacetic acid (TCA) extraction step and centrifugation in the UCP-LF CAA assay may go a long way to aid its potential as a POC tool. We also propose the development of a CAA-specific aptamer (short protein/antigen binding oligonucleotide) as a possible alternative to monoclonal antibodies (mAb) in the assay. Conclusion UCP-LF has great potential for POC application.

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Section: Methodsmentioning

confidence: 99%

“…The lack of proper diagnostic procedures has significant implications for the epidemiology of the disease [ 4 , 5 ]. For effective control of schistosomiasis, new or improved detection approaches are necessary, especially in nonendemic areas [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

UCP-LF and other assay methods for schistosome circulating anodic antigen between 1978 and 2022

Fasogbon

Aja

Ondari

et al. 2023

Biology Methods and Protocols

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“…They are more common in the community as the average age of the population rises, becoming a serious worldwide diffuse health problem [ 2 ]. Annual incidence rates of NDDs are typically approximated at 10 to 15 per 100,000 people worldwide [ 3 ]. The diagnosis of NDDs is challenging because of the variety of clinical signs and symptoms and it is frequently only confirmed with a neuropathological investigation following the patient’s passing [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

New Insights into Oxidative Stress and Inflammatory Response in Neurodegenerative Diseases

Scarian,

Viola,

Dragoni

et al. 2024

IJMS

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Oxidative stress (OS) and inflammation are two important and well-studied pathological hallmarks of neurodegenerative diseases (NDDs). Due to elevated oxygen consumption, the high presence of easily oxidizable polyunsaturated fatty acids and the weak antioxidant defenses, the brain is particularly vulnerable to oxidative injury. Uncertainty exists over whether these deficits contribute to the development of NDDs or are solely a consequence of neuronal degeneration. Furthermore, these two pathological hallmarks are linked, and it is known that OS can affect the inflammatory response. In this review, we will overview the last findings about these two pathways in the principal NDDs. Moreover, we will focus more in depth on amyotrophic lateral sclerosis (ALS) to understand how anti-inflammatory and antioxidants drugs have been used for the treatment of this still incurable motor neuron (MN) disease. Finally, we will analyze the principal past and actual clinical trials and the future perspectives in the study of these two pathological mechanisms.

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“…6,7 Although depression affects millions, limited studies have been conducted on the prophylactic approach to its treatment. Several factors precipitate depressive behavior from physical, emotional or environmental (external) stressors such as fatigue, occupational hazards, loss of loved ones or internal stressors, like diseases, inflammation [8][9][10] and alcohol especially in genetically-predisposed individuals. 11 Ethanol increases levels of reactive oxygen species (ROS), which diminish cellular detoxification and repair capacity causing oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Fluoxetine attenuates stress-induced depression-like behavior due to decrease in pro-inflammatory cytokines in male rats

Nabirumbi,

Onohuean,

Drago

et al. 2024

Science Progress

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Background: Pro-inflammatory cytokines are implicated in depression caused by both environmental- and alcohol-induced stress. The purpose of the study was to investigate the cytokine levels in serum and hippocampus following induction of depression-like behaviors (DLB) by either forced swimming test (FST) or ethanol-induced DLB (EID). We also investigated the effect of prior administration of antidepressant drug fluoxetine on cytokines in animals exposed to both models of DLB. Methods: Animals were pretreated with fluoxetine before inducing DLB, while DLB was induced in some animals using FST and ethanol in different groups of rats without fluoxetine pretreatment. The ELISA was used to detect changes in cytokine (IL-1β, IL-6, and TNF-α) levels in serum and hippocampus. Results: The mean levels of IL-1β and IL-6 measured in serum and hippocampus were significantly higher in FST and EID models when compared to the control group. The serum concentrations of IL-1β and IL-6 were significantly reduced in animals pre-treated with 5 mg/kg and 10 mg/kg of fluoxetine in both FST and EID models when compared to the untreated FST and EID groups respectively. Conclusions: In conclusion, both environment and alcohol can induce stress and DLB in rats with similar intensity, and their mechanisms of DLB induction involve activation of pro-inflammatory cytokines. Moreover, fluoxetine can prevent stress-induced inflammation in models of DLB.

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Epidemiology of neurodegenerative diseases in the East African region: A meta-analysis

Cited by 18 publications

References 94 publications

UCP-LF and other assay methods for schistosome circulating anodic antigen between 1978 and 2022

UCP-LF and other assay methods for schistosome circulating anodic antigen between 1978 and 2022

New Insights into Oxidative Stress and Inflammatory Response in Neurodegenerative Diseases

Fluoxetine attenuates stress-induced depression-like behavior due to decrease in pro-inflammatory cytokines in male rats

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