Epidemiology of Neuromelioidosis in Asia-Pacific: A Systematic Review

Zamzuri, Mohd ‘Ammar Ihsan Ahmad; Jamhari, Mohd Nazrin; Nawi, Haniff Mohd; Hassan, Mohd Rohaizat; Pang, Nicholas Tze Ping; Kassim, Mohd Amiruddin Mohd; Rahim, Syed Sharizman Syed Abdul; Jeffree, Mohammad Saffree; Lee, Shi Yun

doi:10.3889/oamjms.2021.6688

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…In Southeast Asia, cerebral abscess due to disseminated melioidosis is the most common neurological manifestation accounting for approximately 4% of melioidosis cases while in northern Australia, encephalomyelitis is the predominant manifestation. Presenting symptoms can be in the form of seizures, and focal neurological deficits like limb weakness or delirium [ 2 , 15 ]. Cranial nerve palsies are also known to occur [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Disseminated Melioidosis With Cerebritis

Bhat¹,

Gosavi²,

Krishnan³

et al. 2023

Cureus

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Melioidosis is caused by Burkholderia pseudomallei, a Gram-negative, facultative intracellular bacterium. Because melioidosis can mimic many diseases, it requires more advanced laboratory facilities with the necessary expertise and can become an underdiagnosed yet serious infection with high mortality and morbidity . Our patient is a middle-aged male with new-onset uncontrolled type 2 diabetes mellitus who presented with high-grade fever, productive cough and altered mental status. CT thorax showed diffuse middle and lower zone consolidation while MRI brain noted meningitis with cerebritis. Blood culture grew Burkholderia pseudomallei . The patient was started on meropenem for melioidosis, however, no adequate improvement was seen. In view of this inadequate response, parenteral cotrimoxazole was added. Significant improvement was noted and cotrimoxazole was continued for six months.

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Section: Discussionmentioning

confidence: 99%

A Case of Disseminated Melioidosis With Cerebritis

Bhat¹,

Gosavi²,

Krishnan³

et al. 2023

Cureus

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Neuromelioidosis: A farmer’s bane

Dinesh,

Gupta,

Gorthi

2024

JNRP

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Neuromelioidosis is a fatal infection caused by Burkholderia pseudomallei. It is a Gram-negative bacillus that belongs to the Burkholderia genus. B. pseudomallei is a category B bioterrorism agent classified by the center for disease control. Here, we present an unusual case of neuromelioidosis with central nervous system involvement (meningitis, empyema, and vasculitic infarcts) and peripheral nervous system involvement (spinal cord involvement) as well as extra-neuronal involvement.

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A Rare Case of Neuromelioidosis Presenting As Brain Abscess in Patient Complaining of Long Standing Headache

Wiwing,

Suryadinata,

Tjandra

2024

MJMHS

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Melioidosis is a rare disease caused by Burkholderia pseudomallei, which may manifest with varying degrees of organ involvement, ranging from isolated organ to multi-systemic impairment. Patients with melioidosis may exhibit a wide spectrum of symptoms, from asymptomatic to severely ill. While there have been reported cases of melioidosis affecting various organs, there is limited information available on its neural involvement. In this unique case, we present a patient with no specific symptoms other than a persistent headache, who possesses only type 2 diabetes mellitus and old age as potential risk factors. Notably, the patient has no history of trauma or surgery that might have contributed to the infection. Upon MRI examination, multiple abscesses were discovered in the left parieto-occipito-temporal region. Subsequent culturing of these abscesses confirmed the presence of B. pseudomallei. The patient underwent a 4-week treatment regimen involving intravenous ceftazidime and oral double-strength co-trimoxazole. At the two-week mark of this therapy, the patient returned for a scheduled follow-up and exhibited no symptoms, remaining in good health ever since.

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Epidemiology of Neuromelioidosis in Asia-Pacific: A Systematic Review

Cited by 3 publications

References 31 publications

A Case of Disseminated Melioidosis With Cerebritis

A Case of Disseminated Melioidosis With Cerebritis

Neuromelioidosis: A farmer’s bane

A Rare Case of Neuromelioidosis Presenting As Brain Abscess in Patient Complaining of Long Standing Headache

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