Epidemiology of Nonesophageal Eosinophilic Gastrointestinal Diseases in Symptomatic Patients: A Systematic Review and Meta-Analysis

Licari, Amelia; Votto, Martina; Scudeller, Luigia; Silvestri, Annalisa De; Rebuffi, Chiara; Cianferoni, Antonella

doi:10.1016/j.jaip.2020.01.060

Cited by 49 publications

(29 citation statements)

References 39 publications

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“…Eosinophilic ascites denotes involvement of serosal layer. 8 Rarely, there may be eosinophilic vasculitis which may cause intestinal perforation. 10…”

Section: Discussionmentioning

confidence: 99%

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Hyper-eosinophilic syndrome: An uncommon cause of chronic abdominal pain in an elderly male

et al. 2021

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Hypereosinophilia is defined as an absolute eosinophil count of ≥1.5 × 109/L, and its presence with involvement of at least one organ system defines the hypereosinophilic syndrome. It may occur with parasitic infestation, connective tissue disorder or rarely in clonal disorders such as eosinophilic leucaemia. Organ systems that may be involved include the cardiovascular, central nervous, respiratory and gastrointestinal systems. In the latter, a wide spectrum of clinical presentation may be seen from trivial, to debilitating or rarely fatal. We report an elderly male with a history of bronchial asthma, obstructive sleep apnoea and food allergy who presented with chronic abdominal pain and weight loss. Abdominal examination and routine evaluation were essentially normal other than a peripheral hyper-eosinophilia. We witnessed a brisk and lasting response to an elimination diet and corticosteroids.

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“…Eosinophilic ascites denotes involvement of serosal layer. 8 Rarely, there may be eosinophilic vasculitis which may cause intestinal perforation. 10…”

Section: Discussionmentioning

confidence: 99%

“…7 Common clinical features in patients with GI involvement include diarrhoea, vomiting and abdominal pain. 8…”

Section: Introductionmentioning

confidence: 99%

Hyper-eosinophilic syndrome: An uncommon cause of chronic abdominal pain in an elderly male

et al. 2021

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“…Most data come from population-based studies, conducted primarily in North America and Europe [ 2 , 3 , 17 – 21 ]. Incidence rates range from 2.1/100,000/year in the Netherlands [ 4 ] to 12.8/100,000/year in Ohio in the United States [ 22 ].…”

Section: Epidemiologymentioning

confidence: 99%

Pediatric eosinophilic esophagitis: a review for the clinician

et al. 2021

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Eosinophilic esophagitis (EoE) is a chronic clinical-pathologic disease characterized by eosinophilic infiltration of the esophageal epithelium with esophageal dysfunction symptoms.EoE can occur at any age and has different clinical manifestations depending on the age onset.To date, esophago-gastroduodenal endoscopy (EGD) with biopsy is the gold-standard for EoE diagnosis.According to the recent consensus guidelines, proton pump inhibitors, corticosteroids and elimination diets could be a first-line therapy option. The aim of the treatment is clinical and histological remission for preventing long-lasting untreatable fibrosis.A multidisciplinary approach (allergist, gastroenterology, dietitian, and pathologist) is recommended for managing patients affected by EoE, given the complexity of its treatment.This review will provide a practical guide to assist pediatricians treating children with EoE.Moreover, it highlights the unmet needs in diagnosis and treatment that require urgent attention from the scientific community in the aim of improving the management of patients with EoE.

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“…It is estimated that EoE affects about 0.5-1/1,000 patients in the USA, varying widely across the different Countries and mostly prevailing in Caucasian patients and male sex ( 3 ). However, in the last 20 years, several epidemiological studies showed a significant increase in the epidemiology of EGIDs, partially related to improved medical awareness and knowledge through modern diagnostic instruments ( 4 – 6 ). It was also postulated that changes in environmental factors may have contributed to the significant increase in EoE epidemiology ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Diet Therapy in Eosinophilic Esophagitis. Focus on a Personalized Approach

et al. 2022

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Eosinophilic esophagitis (EoE) is a chronic allergic disease defined by a marked eosinophilic inflammation and symptoms of esophageal dysfunction. EoE is a heterogeneous disease and severely impacts the quality of life of affected patients. The current therapeutic management of EoE is based on two cornerstones: medication and diet therapy, both effective but limited by several critical issues. The choice of one or the other therapy might depend on the different disease phenotypes (allergic vs. non-allergic, inflammatory vs. fibro-stenotic), patient's age (adult vs. childhood-onset), food habits, patient/family preference, and familiar financial resource. Diet therapy is a successful treatment but limited by low patient adherence, the need for several endoscopies, food restrictions, psychosocial impact, and potential nutritional deficiencies. All these limitations could be effectively overcome with multidisciplinary and personalized management. This review summarizes the most recent evidence on the dietary elimination approaches and will provide a practical guide to clinicians in managing and implementing dietary therapy for patients with EoE.

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Epidemiology of Nonesophageal Eosinophilic Gastrointestinal Diseases in Symptomatic Patients: A Systematic Review and Meta-Analysis

Cited by 49 publications

References 39 publications

Hyper-eosinophilic syndrome: An uncommon cause of chronic abdominal pain in an elderly male

Hyper-eosinophilic syndrome: An uncommon cause of chronic abdominal pain in an elderly male

Pediatric eosinophilic esophagitis: a review for the clinician

Diet Therapy in Eosinophilic Esophagitis. Focus on a Personalized Approach

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