Epidemiology of nosocomial bloodstream infections in Estonia

Mitt, Piret; Adamson, Vivika; Lõivukene, Krista; Lang, K.; Telling, Kaidi; Päro, K.; Rõõm, Aino; Naaber, Paul; Maimets, Matti

doi:10.1016/j.jhin.2009.01.008

Cited by 35 publications

(32 citation statements)

References 17 publications

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“…With this our findings are in accordance with Jaureguy et al who, in an intrapartum prophylaxis study, failed to demonstrate that amoxicillin selects for betalactam resistant enterobacteria [11]. At present in most countries all Enterobacteraceae but E. coli have become uniformly resistant to ampicillin [32,33], and thus it is not surprising that ampicillin and penicillin have similar influence on gut colonization with Gram-negative bacteria. Still, one should bear in mind that our study was conducted in a country with low antibiotic resistance [34] including low prevalence of extended spectrum beta-lactamase (ESBL) producing microorganisms in the PICU setting (approximately 2%) [32].…”

Section: Discussionsupporting

confidence: 92%

“…At present in most countries all Enterobacteraceae but E. coli have become uniformly resistant to ampicillin [32,33], and thus it is not surprising that ampicillin and penicillin have similar influence on gut colonization with Gram-negative bacteria. Still, one should bear in mind that our study was conducted in a country with low antibiotic resistance [34] including low prevalence of extended spectrum beta-lactamase (ESBL) producing microorganisms in the PICU setting (approximately 2%) [32]. Future studies should identify whether these data also apply to countries with high resistance rates.…”

Section: Discussionmentioning

confidence: 99%

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Impact of empiric antibiotic regimen on bowel colonization in neonates with suspected early onset sepsis

Parm

Metsvaht

Sepp

et al. 2010

Eur J Clin Microbiol Infect Dis

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Abstract The purpose of this study was to compare the impact of ampicillin and penicillin used for empiric treatment of early onset sepsis (EOS) on initial gut colonization by aerobic and facultative anaerobic microorganisms. A cluster-randomized, two-center, switch-over study was conducted in two paediatric intensive care units in Estonia and included 276 neonates. Rectal swabs were collected twice a week until discharge or day 60. Colonizing microbes were identified on species level and tested for ampicillin resistance (AR). The number of patients colonized with Gram negative microorganisms and Candida spp was similar in both treatment arms but ampicillin resulted in longer colonization duration (CD) of K. pneumonia (p=0.012), AR Serratia spp (p=0.012) and Candida spp (p=0.02) and penicillin in that of AR Acinetobacter spp (p=0.001). As for Gram positive microorganisms penicillin treatment was associated with a greater number of colonized patients and higher CD of Enterococcus spp and S. aureus but lower ones of S. haemolyticus and S. hominis. Influence of ampicillin and penicillin on initial gut colonization is somewhat different but these differences are of low clinical relevance and should not be a limiting step when choosing between these two antibiotics for the empiric treatment of EOS.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Impact of empiric antibiotic regimen on bowel colonization in neonates with suspected early onset sepsis

Parm

Metsvaht

Sepp

et al. 2010

Eur J Clin Microbiol Infect Dis

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“…Yetersiz antimikrobiyal tedavi klinik olarak önemli patojenlerin antibiyotik direnciyle yakından ilişkilidir. Bu problemin asıl nedeni ise multifaktoriyaldir ve antimikrobiyal ajanların uygunsuz kullanımı sonucu selektif baskıyı içerir, birçok hastane kullanılan geniş spektrumlu antimikrobiyal ajanları gereksiz stoklar ve diğer bir kısmının ise dirençli hastane florasından dolayı oluşan problemleri mevcuttur (1)(2)(3)(4)(5).…”

Section: Discussionunclassified

“…Tıptaki gelişmelere rağmen hastane enfeksiyonları halen tüm dünyayı ilgilendiren önemli bir sorundur. Kan kültürü, kan dolaşımı enfeksiyonlarının tanımlanmasında çok önemlidir ve kan dolaşımı enfeksiyonları yüksek mortalite ile seyretmektedir (1)(2)(3)(4).…”

Section: Introductionunclassified

“…Genişlemiş spektrumlu beta laktamazlar (GSBL) ve AmpC gram negatif bakteriler arasında, metisilin dirençli Staphylococcus aureus ve keza vankomisin dirençli enterokok, gram pozitif bakteriler arasında kullanılan antibiyotiklerin çoğuna karşı dirence neden olan majör dirençli fenotiplerdir (1)(2)(3)(4)(5). Etkenin hızla üretilmesi, tanımlanması ve yayılımının engellenmesi hasta için hayati öneme sahiptir.…”

Section: Introductionunclassified

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Antimicrobial Susceptibility and Microorganisms Isolated from Blood Cultures of Hospitalized Patients in Intensive Care Units

Küçükateş¹,

Gültekin²

2016

Haseki

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ÖzAmaç: Çalışmamızda, yoğun bakım ünitelerimizde yatan hastaların kan kültürlerinde üreyen mikroorganizmaların değerlendirilmesi ve tedavi için uygun antimikrobiyal ajanların saptanması amaçlandı. Aim:The aim of this study was to evaluate microorganism growth in blood cultures of hospitalized patients in our intensive care units and to determine appropriate antimicrobial agents for treatment. Yöntemler Methods:We retrospectively investigated the blood cultures obtained from the patients hospitalized in the Coronary and Surgical Intensive Care Units at the Institute of Cardiology, İstanbul University, between July 2013 and December 2014. All microorganisms were identified using the conventional methods.Results: A total of 1034 blood cultures were obtained from 324 patients. Microbial growth was detected in 174 (16.8%) blood cultures of 68 patients. Among all microbial growth, 113 (58.55%) were gram-positive bacteria, 69 (35.75%) were gram-negative rods and 11 (5.7%) were fungi. Staphylococcus aureus was the most frequent microorganism (48; 24.87%), followed by coagulasenegative Staphylococci (35;18,13%), Enterococcus spp. (30;15,54%), Stenotrophomonas maltophilia, Escherichia coli, and Pseudomonas spp. 60.4% of Staphylococcus aureus were methicillin-resistant and 65.7% of coagulase-negative Staphylococci were also methicillinresistant. All Staphylococci and Enterococci were not resistant to vancomycin, teicoplanin and tigecycline. All the gram-negative rods were susceptible to colistin and tigecycline, followed by imipenem (71.6%) and meropenem (70.7%). Conclusions:We assume that infection control measures must be increased due to high antibiotic resistance and besides, antibiotic policies should be improved.Keywords: Blood cultures, intensive care unit, antimicrobial resistance Abs tractYa z›fl maAd re si/Ad dressforCor res pon den ce:Emine Küçükateş

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Nosocomial bloodstream infections in neurosurgery: a 10-year analysis in a center with high antimicrobial drug-resistance prevalence

et al. 2016

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Epidemiology of nosocomial bloodstream infections in Estonia

Cited by 35 publications

References 17 publications

Impact of empiric antibiotic regimen on bowel colonization in neonates with suspected early onset sepsis

Impact of empiric antibiotic regimen on bowel colonization in neonates with suspected early onset sepsis

Antimicrobial Susceptibility and Microorganisms Isolated from Blood Cultures of Hospitalized Patients in Intensive Care Units

Nosocomial bloodstream infections in neurosurgery: a 10-year analysis in a center with high antimicrobial drug-resistance prevalence

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