Epidemiology of nosocomial fungal infections: invasive aspergillosis and the environment

VandenBergh, Marjolein F. Q.; Verweij, Paul E.; Voß, Andreas

doi:10.1016/s0732-8893(99)00026-7

Cited by 111 publications

(65 citation statements)

References 55 publications

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“…Accordingly, several outbreaks of invasive aspergillosis have been associated with construction and/or renovation activities in and around hospitals (Sarubbi et al, 1982;VandenBergh et al, 1999), activities that markedly increase the number of spores in the air. Also, in several studies the link between infection by A. flavus and the contamination of the environment was clearly demonstrated by molecular typing methods (Rath & Ansorg, 1997;Diaz-Guerra et al, 2000) (see below).…”

Section: Home and Hospital Airmentioning

confidence: 99%

Aspergillus flavus: human pathogen, allergen and mycotoxin producer

et al. 2007

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Aspergillus infections have grown in importance in the last years. However, most of the studies have focused on Aspergillus fumigatus, the most prevalent species in the genus. In certain locales and hospitals, Aspergillus flavus is more common in air than A. fumigatus, for unclear reasons. After A. fumigatus, A. flavus is the second leading cause of invasive aspergillosis and it is the most common cause of superficial infection. Experimental invasive infections in mice show A. flavus to be 100-fold more virulent than A. fumigatus in terms of inoculum required. Particularly common clinical syndromes associated with A. flavus include chronic granulomatous sinusitis, keratitis, cutaneous aspergillosis, wound infections and osteomyelitis following trauma and inoculation. Outbreaks associated with A. flavus appear to be associated with single or closely related strains, in contrast to those associated with A. fumigatus. In addition, A. flavus produces aflatoxins, the most toxic and potent hepatocarcinogenic natural compounds ever characterized. Accurate species identification within Aspergillus flavus complex remains difficult due to overlapping morphological and biochemical characteristics, and much taxonomic and population genetics work is necessary to better understand the species and related species. The flavus complex currently includes 23 species or varieties, including two sexual species, Petromyces alliaceus and P. albertensis. The genome of the highly related Aspergillus oryzae is completed and available; that of A. flavus in the final stages of annotation. Our understanding of A. flavus lags far behind that of A. fumigatus. Studies of the genomics, taxonomy, population genetics, pathogenicity, allergenicity and antifungal susceptibility of A. flavus are all required.

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Section: Home and Hospital Airmentioning

confidence: 99%

Aspergillus flavus: human pathogen, allergen and mycotoxin producer

et al. 2007

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“…Warm and moist environment, poor ventilation and insufficient sanitation, and long-term storage of feed, are predisposing conditions for aspergillosis and can increase the amount of the spores in the air. Spores often become airborne and spread to the environment by wind and can enter into the respiratory system by inhalation (212). In Turkey, aspergillosis has been detected predominantly in the homes of asthmatic patients (213,214).…”

Section: Fungal Zoonotic Diseases In Turkeymentioning

confidence: 99%

Overview of Zoonotic Diseases in Turkey: The One Health Concept and Future Threats

İncı¹,

Doğanay²,

Özdarendeli³

et al. 2018

TurkiyeParazitolDerg

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Zoonotic infections are globally important diseases and lead to huge economic losses in both low-and middle-income and high-income countries. Global warming, environmental and ecological changes, illegal movement of animals and humans, regional civil wars, and poverty are predisposing factors for the emergence of zoonotic infections and their distribution worldwide; they are also a big threat for the future. In addition, environmental pollution and antimicrobial resistance are immense serious threats and dangers to prevent and control zoonotic infections. The natural location of Turkey allows many emerged or re-emerged infections with zoonotic characteristics by animal movements, such as bird immigrations, and by human movements due to civil wars as seen with regional refugees. Numerous zoonotic diseases, including 37 bacterial, 13 fungal, 29 viral, 28 parasitic (3 trematodes, 7 cestodes, 10 nematodes, and 8 protozoan), and totally 107 infections, have been reported from Turkey to date. Additionally, many ectoparasitic zoonoses within 15 different arthropod groups and one leech infestation have been reported from Turkey to date. The "One Health" initiative is particularly relevant for developing strategies to combat zoonotic diseases. In this article, we review the occurrence of zoonotic diseases in man and animals in Turkey in the light of the "One Health" perspective.

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“…In this setting, outbreaks of infection have been linked to construction work that results in high levels of contamination of the hospital environment [8]. Other, less invasive forms of pulmonary and upper respiratory/orbital aspergillosis can be found in older adults and are not acquired in the hospital; instead, they develop as a result of environmental exposure to these ubiquitous organisms [38].…”

Section: Primary Fungal Growth and High-risk Groupsmentioning

confidence: 99%

“…The total annual asthma cost attributable to exposure to dampness and mold, calculated by multiplying the selected estimate of costs by the attributable fraction of 21%, is approximately $3.5 billion [4]. Moreover, reported cases of hospital-acquired fungal infections in hospitalized and immunosuppressive patients are on the rise [5][6][7][8]. Other groups at risk, such as the elderly [9] and young children [10,11], have been noted for their susceptibility to the harmful effects of indoor air and fungi.…”

Section: Introductionmentioning

confidence: 99%