Epidemiology of NSAID-related gastroduodenal mucosal injury

Aalykke, Claus; Lauritsen, K

doi:10.1053/bega.2001.0230

Cited by 55 publications

(34 citation statements)

References 79 publications

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“…The study presented here was in accordance with the study of Aalykke [18] who found that the incidence of dyspepsia as a gastro intestinal side effect was strongly correlated with the duration of administration of Ibuprofen.…”

Section: Discussionsupporting

confidence: 92%

The Incidence of Upper Gastrointestinal Complications of Non-Steroidal Anti-Inflammatory Drugs in Elderly Patients

Hassanein¹,

Abdelrahim²,

Said³

et al. 2014

Med-Science

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Section: Discussionsupporting

confidence: 92%

The Incidence of Upper Gastrointestinal Complications of Non-Steroidal Anti-Inflammatory Drugs in Elderly Patients

Hassanein¹,

Abdelrahim²,

Said³

et al. 2014

Med-Science

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“…Besides personal risk factors, the type and the dose of NSAIDs, duration of exposure to the drug and concomitant use of other drugs play an important role on NSAID-related GI side effects [11] . In our study, we observed a positive correlation between endoscopically observed gastric injury and age, although none of our patients were in the age group (> 60 years) established as an individual risk factor.…”

Section: Discussionmentioning

confidence: 99%

“…Intramucosal hemorrhage, petechia, and mucosal erosions have been observed endoscopically with shortterm usage. Superficial ulceration typically appears within 1 wk [11] . Following single-dose (650-1300 mg) aspirin intake, gastric lesions occur with a 100% certainty [12] .…”

Section: Discussionmentioning

confidence: 99%

Endoscopic and histopathological evaluation of acute gastric injury in high-dose acetaminophen and nonsteroidal anti-inflammatory drug ingestion with suicidal intent

Soylu¹,

Dolapcioglu²,

Dolay³

et al. 2008

WJG

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AIM:To evaluate endoscopic and histopathologic aspects of acute gastric injury due to ingestion of high-dose acetaminophen and nonsteroidal antiinflammatory drugs (NSAIDs) with respect to some risk factors and patient characteristics. METHODS:The study group consists of 50 patients admitted to emergency department with high dose analgesic ingestion (group Ⅰ) with suicidal intent. Thirty patients with or without mild complaints of dyspepsia (group Ⅱ) were selected as the control group. The study group was stratified according to the use of type and number of analgesics. Endoscopic findings were evaluated according to the Lanza score (LS), expressing the severity of the gastroduodenal damage and biopsies according to a scoring system based on histopathologic findings of acute erosive gastritis. RESULTS: Gastroduodenal damage was significantly more severe in group Ⅰ compared to group Ⅱ (P < 0.01). The LS was similar in both groups Ⅰa and Ⅰb. However LS was significantly higher in patients who had ingested multiple NSAIDs (group Ⅰc) compared to other patients (P < 0.01). The LS was correlated to age (P < 0.01) and total amount of drug ingested (P < 0.05) in group Ⅰ; but it was not correlated with Helicobacter pylori (H pylori) infection or duration of exposure (P > 0.05). The biopsy score (BS) was higher in group Ⅰ than group Ⅱ (P < 0.01), and higher in group Ⅰb than group Ⅰa (P < 0.05). CONCLUSION: The histopathologic damage was more severe among NSAID ingesting patients compared to those ingesting only acetaminophen and there is no significant difference in the endoscopic findings between the groups. There is no significant difference in the LS between the groups. This lack of significance is remarkable in terms of the gastric effects of highdose acetaminophen.

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“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are often used to relieve pain in such patients. Because of the untoward effect of non-selective NSAIDs on the upper gastrointestinal tract, mainly among the elderly population, 1 there is a trend to use NSAIDs of newer generation such as highly selective cyclooxygenase-2 (COX-2) inhibitors. These new COX-2 inhibitors (rofecoxib and celecoxib) mainly inhibit 'inducible' cyclooxygenase at the site of the inflammation, and do not influence 'constitutional' cyclooxygenase.…”

Section: Introductionmentioning

confidence: 99%

The different patterns of blood pressure elevation by rofecoxib and nabumetone

Reitblat¹,

Zamir²,

Estis³

et al. 2002

J Hum Hypertens

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Hypertension and knee osteoarthritis (OA) are frequent comorbidities. Nonsteroidal anti-inflammatory drugs (NSAIDs) are often used to relieve pain in such patients. In the last decade selective NSAIDs are used more commonly since they lead to less gastrointestinal complications. As has been shown, the treatment with NSAIDs may cause a mild rise of arterial blood pressure (BP). The influence of selective NSAIDs on BP, particularly in hypertensive patients has still to be investigated. The aim of this study was to determine arterial BP changes in patients suffering from stable arterial hypertension and knee OA and treated with rofecoxib or nabumetone. Two groups of patients with knee OA and stable arterial hypertension received either 25 mg rofecoxib once daily or namebutone 2000 mg once daily during the first week of treatment and 1000 mg for the following 3 weeks. Twenty-four hour arterial BP monitoring was performed prior to initiation of treatment and at the end of a 4-week period. The results were that no changes were found in

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Epidemiology of NSAID-related gastroduodenal mucosal injury

Cited by 55 publications

References 79 publications

The Incidence of Upper Gastrointestinal Complications of Non-Steroidal Anti-Inflammatory Drugs in Elderly Patients

The Incidence of Upper Gastrointestinal Complications of Non-Steroidal Anti-Inflammatory Drugs in Elderly Patients

Endoscopic and histopathological evaluation of acute gastric injury in high-dose acetaminophen and nonsteroidal anti-inflammatory drug ingestion with suicidal intent

The different patterns of blood pressure elevation by rofecoxib and nabumetone

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