Epidemiology of Ocular Manifestations in Autoimmune Disease

Glover, Katie; Mishra, D. N.; Singh, Thakur Raghu Raj

doi:10.3389/fimmu.2021.744396

Cited by 38 publications

(28 citation statements)

References 209 publications

(221 reference statements)

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“…A unifying role of the oxidative stress between cataracts and rheumatoid arthritis has also been suggested [ 26 ]. The body’s immune system attacking self-antigens also plays a crucial role in arthritis and ocular comorbidities [ 27 ]. Corticosteroid could also be a linkage between these two comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Trends of Multimorbidity Patterns over 16 Years in Older Taiwanese People and Their Relationship to Mortality

Yeh

Wei

et al. 2022

IJERPH

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Understanding multimorbidity patterns is important in finding a common etiology and developing prevention strategies. Our aim was to identify the multimorbidity patterns of Taiwanese people aged over 50 years and to explore their relationship with health outcomes. This longitudinal cohort study used data from the Taiwan Longitudinal Study on Aging. The data were obtained from wave 3, and the multimorbidity patterns in 1996, 1999, 2003, 2007, and 2011 were analyzed separately by latent class analysis (LCA). The association between each disease group and mortality was examined using logistic regression. Four disease patterns were identified in 1996, namely, the cardiometabolic (18.57%), arthritis–cataract (15.61%), relatively healthy (58.92%), and multimorbidity (6.9%) groups. These disease groups remained similar in the following years. After adjusting all the confounders, the cardiometabolic group showed the highest risk for mortality (odds ratio: 1.237, 95% confidence interval: 1.040–1.472). This longitudinal study reveals the trend of multimorbidity among older adults in Taiwan for 16 years. Older adults with a cardiometabolic multimorbidity pattern had a dismal outcome. Thus, healthcare professionals should put more emphasis on the prevention and identification of cardiometabolic multimorbidity.

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Section: Discussionmentioning

confidence: 99%

Trends of Multimorbidity Patterns over 16 Years in Older Taiwanese People and Their Relationship to Mortality

Yeh

Wei

et al. 2022

IJERPH

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“…However, several studies have demonstrated that this eye condition is frequently disrupted in diverse ocular pathologies in which several immunological components are implicated in the etiopathology of these ocular diseases [ 21 ]. In this sense, the immune system has been involved directly or indirectly in a wide range of ocular pathologies of the anterior and posterior chambers of the eye [ 22 ]. Dry eye syndromes, autoimmune uveitis, age-related macular degeneration (AMD), glaucoma, and autoimmune retinopathy are some of the anterior and posterior segment diseases in which the immune system plays a main role in their pathological development [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Dry eye syndromes, autoimmune uveitis, age-related macular degeneration (AMD), glaucoma, and autoimmune retinopathy are some of the anterior and posterior segment diseases in which the immune system plays a main role in their pathological development [ 21 ]. Some autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s syndrome, and graft-versus-host disease are involved in the development of several ocular pathologies mentioned above [ 22 , 23 ]. Although CD4+ T cells have been described in the last two decades as the main actors in the pathogenesis of ocular autoimmune diseases, several studies have demonstrated that B cells and the autoantibodies produced by them also have an outstanding role in the immunopathogenic process of these diseases [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Optimization of a Plasma Rich in Growth Factors Membrane for the Treatment of Inflammatory Ocular Diseases

et al. 2022

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The main purpose of the present study is to develop an immunosafe fibrin membrane obtained by plasma rich in growth factors technology (is-mPRGF) with improved mechanical properties that could be applied in patients with inflammatory ocular diseases. Blood was drawn from three healthy donors and centrifuged, and the collected PRGF was activated and distributed into two groups: (i) mPRGF: a PRGF membrane maintained at 37 °C for 30 min; (ii) IS5+30: mPRGF incubated at 37 °C for 5 min and then incubated at 56 °C for 30 min. The content of both membranes was analyzed for several growth factors such as IgE and the complement activation, as well as biological activity on different ocular surface cells. Furthermore, the physical and mechanical characterizations were also evaluated. IS5+30 completely reduced the complement activity and decreased the IgE while preserving the concentration of the main growth factors. IS5+30 induced similar biological activity regarding mPRGF on the different ocular surface cells analyzed. Furthermore, no significant differences in release kinetics or fibrin degradation were observed between both membranes. Summarizing, IS5+30 totally reduces complement activity while preserving the concentration of most growth factors and their biological activity. Furthermore, the physical and mechanical properties of the fibrin membrane are preserved after heat inactivation.

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“…Bu sebeple, göz muayenesi ortaya çıkan oküler semptomları zamanında teşhis etmek, araştırmak ve tedavi etmek için hastalık yönetiminin rutin bir parçası haline gelmelidir. [3] Tablo 1. Sistemik…”

Section: Introductionunclassified

Autoimmune Diseases and Retina

2023

Güncel Retina (Current Retina)

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Autoimmune diseases are a group of diseases that can result in organ-specific and/or systemic (systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis,...) anatomical deformation and loss of function as a result of the body's immune system attacking its own antigens under the influence of genetic and environmental factors. The eye is a potential target for complications related to autoimmunity, and depending on the severity of the immune response, vision-threatening problems can be observed. Immune complexes accumulate in and around the vessel walls as a result of humoral immunity, in which the autoantibody-related complement system is activated, and cellular immune response can lead to retinal vasculitis, vaso-occlusion, retinal hemorrhage, retinal ischemia, ischemic optic neuropathy, and inflammation of periorbital tissues. Therefore, the role of ophthalmologists in disease management is important in diagnosing, investigating, and treating ocular symptoms in a timely manner. Early diagnosis and treatment can play a critical role to decrease the risk of irreversible immunological damage to the retinal tissue. A multi-disciplinary approach for complete management and evaluation is needed in this disease group. This study aimed to provide a detailed review of the current clinical perspective for the diagnosis, workup, and treatment of autoimmune diseases with retinal manifestations. Systemic lupus erythematosus, Polyarteritis Nodosa, Dermatomyositis, Scleroderma, Wegener's Granulomatosis, Churg-Strauss Syndrome, Takayasu Arteritis, Susac Syndrome, and Nodular Panniculitis are discussed under this heading.

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Epidemiology of Ocular Manifestations in Autoimmune Disease

Cited by 38 publications

References 209 publications

Trends of Multimorbidity Patterns over 16 Years in Older Taiwanese People and Their Relationship to Mortality

Trends of Multimorbidity Patterns over 16 Years in Older Taiwanese People and Their Relationship to Mortality

Optimization of a Plasma Rich in Growth Factors Membrane for the Treatment of Inflammatory Ocular Diseases

Autoimmune Diseases and Retina

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