Epidemiology of Oral Lichen Planus in a Cohort of South Indian Population: A Retrospective Study

Abstract

Background:Oral lichen planus (OLP) is an immune-mediated potentially malignant disorder of the oral cavity. Dysplastic OLP has an altered cytogenic profile and can progress into oral squamous cell carcinoma. The epidemiology of OLP is well-described in several relatively large series from various geographic locations, whereas such series from southern India is rare. The aim of the present study was to determine the epidemiology of OLP in a cohort of South Indian population.Methods:All the case data records of 29,606 patients who visited Mar Baselios Dental College and Hospital, Kerala, India from 2014 to 2015 were retrospectively reviewed. For data review, 122 patients of OLP were selected Estimated were type, number, and location of lesions, clinical manifestation, age of the patient, gender, onset and duration of lesion, stressful life style, habits, skin involvement and associated systemic illness, and presence/absence of dysplasia.Results:When the distribution of OLP among the gender was considered, we found more prevalence in females than males. Fifty-seven percent of patients were associated with stressful lifestyle. Reticular lichen planus was the most common clinical subtype found. Bilateral buccal mucosal was the common site, when the distribution of sites of OLP were compared (P < 0.05). Hypersensitivity reaction was frequently associated with systemic illness with OLP (P < 0.05). Anaplasia was found among 5% of lichen planus lesions.Conclusions:OLP patients had high incidence of hypersensitivity reactions and 5% of OLP lesions showed anaplasia. Long term follow-up is necessary to monitor the recurrence, prognosis, and malignant transformation of OLP.

White oral mucosal lesions among the Yemeni population and their relation to local oral habits

“…The prevalence of this condition among our participants falls within the expected rate. Similar to other studies, we found a positive correlation of lichen planus with older females . Moreover, in the present study, lichen planus was more commonly seen in patients with systemic diseases, a finding which supports previous reports that suggested a positive association between lichen planus and systemic diseases …”

Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta‐analysis of malignant transformation rate by subtype

“…After title/abstract screening, 4324 papers were selected for abstract evaluation. Of these, 92 studies were included in the final analysis . Fourty‐six reports were on LP, 5 on OLL, 28 on LE, 8 on OE, 4 on OSF, and 11 on PVL (all the studies taken for every subgroup sum up to a figure higher than 92 because some studies focused on more than one OPMD).…”

Rate of malignant transformation of oral lichen planus: A systematic review

“…read the 43 papers in full‐length and identified 21 articles for the final data extraction: 18 being retrospective and three being prospective in nature. A summary of the full‐length articles excluded (Bajaj, Khoso, Devrajani, Matlani, & Lohana, ; Bornstein et al, ; Brown, Bottomley, Puente, & Lavigne, ; Brzak et al, ; Budimir et al, ; Casparis et al, ; Chainani‐Wu, Silverman, Lozada‐Nur, Mayer, & Watson, ; Ingafou, Leao, Porter, & Scully, ; Irani, Esfahani, & Ghorbani, ; Jaafari‐Ashkavandi, Mardani, Pardis, & Amanpour, ; Kövesi & Bánóczy, ; Murti et al, ; Pakfetrat, Javadzadeh‐Bolouri, Basir‐Shabestari, & Falaki, ; Rajentheran, McLean, Kelly, Reed, & Nolan, ; Rimkevičius, Aleksejūnienė, Pūrienė, Šeinin, & Rastenienė, ; Rödström, Jontell, Mattsson, & Holmberg, ; Roosaar, Yin, Sandborgh‐Englund, Nyrén, & Axéll, ; Thongprasom et al, ; van der Meij, Schepman, & van der Waal, ; Varghese et al, ; Wang et al, ; Warnakulasuriya et al, ), and the reasons for their exclusion can be obtained electronically (Supporting Information Table ).…”