Epidemiology of organising pneumonia in Iceland

Abstract

Background: Cryptogenic organising pneumonia (COP) has also been called idiopathic bronchiolitis obliterans organising pneumonia. In secondary organising pneumonia (SOP) the causes can be identified or it occurs in a characteristic clinical context. The aim of this study was to determine the incidence and epidemiological features of COP and SOP nationwide in Iceland over an extended period. Methods: A retrospective study of organising pneumonia (OP) in Iceland over 20 years was conducted and the epidemiology and survival were studied. All pathological reports of patients diagnosed with or suspected of having COP or SOP in the period 1984-2003 were identified and the pathology samples were re-evaluated using strict diagnostic criteria. Results: After re-evaluation, 104 patients fulfilled the diagnostic criteria for OP (58 COP and 46 SOP). The mean annual incidence of OP was 1.97/100 000 population (1.10/100 000 for COP and 0.87/ 100 000 for SOP). The mean age at diagnosis was 67 years with a wide age range. The most common causes of death were lung diseases other than OP, and only one patient died from OP. Patients with OP had a lower rate of survival than the general population, but there was no statistical difference between COP and SOP. Conclusions: The incidence of OP is higher than previously reported, suggesting that OP needs to be considered as a diagnosis more often than has been done in the past.

Organizing pneumonia: Manifestation peculiarities, causes, and outcomes

“…According to a recently published nationwide epidemiology study in Iceland, the mean annual incidence of OP (both cryptogenic and secondary) was 1.97 per 100 000 people, which is much higher compared to the findings of other researchers [11]. Several months of illness may continue before the correct diagnosis [13,22].…”

“…Recently published results of the retrospective study in Iceland [11] showed that secondary OP occurred as often as cryptogenic OP. Secondary OP can be related to different types of medications, including amiodarone [35,36], acebutolol [35], nitrofurantoin [37], ticlopidine [38], and anticancer drugs [39][40][41].…”

“…Moreover, OP may be related to lymphoma [9] or carcinoma [10]. OP is a relatively rare entity [11]. Since clinical manifestation is nonspecific and imaging patterns are various, diagnosis may often be delayed [12].…”

A Patient with Organizing Pneumonia Development During the Use of Capecitabine Maintenance Treatment for Gastric Cancer

“…In a 20-year review of national statistics for Iceland, the mean annual incidence of OP was 1.1 per 100,000. Onset of OP is generally in the fifth or sixth decade of life and men and women are affected equally (18). Histopathologic lesion characteristics of OP include excessive proliferation of granulation tissue, and consist of loose collagen-embedded fibroblasts and myofibroblasts, involving alveolar ducts and alveoli.…”

Neumonía criptogénica organizada como diagnóstico diferencial de neumonía que no responde a tratamiento: Report of one case

“…No tiene diferencias por género y puede presentar fiebre, disnea, tos, crépitos inspiratorios de evolución aguda o subaguda 28,29 .…”