Epidemiology of osteosarcoma and Ewing's sarcoma in childhood

Buckley, Jonathan D.; Pendergrass, Thomas W.; Buckley, C M; Pritchard, Douglas J.; Nesbit, Mark E.; Provisor, Arthur J.; Robison, Leslie L.

doi:10.1002/(sici)1097-0142(19981001)83:7<1440::aid-cncr23>3.0.co;2-3

Cited by 87 publications

(42 citation statements)

References 21 publications

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“…The other associations reported here await replication and refinement in future studies that include more narrowly defined cases [possibly using characteristics such as histopathology, biologic markers or cases that have the cytogenetic translocation t (11;22)(q24; q11. [2][3][4][5][6][7][8][9][10][11][12]] and have a greater number of newly diagnosed cases. Although aetiology of ESFT remains obscure, overall there is now strong evidence for an association between ESFT and inguinal hernias 3,4,7,11 and between ESFT and farm-related exposures that include parental occupation in farming.…”

Section: Discussionmentioning

confidence: 99%

A national case‐control study of Ewing's sarcoma family of tumours in Australia

Valery

McWhirter

Sleigh

et al. 2003

Intl Journal of Cancer

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Limited population-based epidemiologic information is available on Ewing's sarcoma family of tumours (ESFT), a rare group of neoplasms. Several associations have been noted on a few studies but results were not consistent, except for exposure to farming among cases and their parents. Here we present the non-farm findings of a nationwide casecontrol study of ESFT in children and young adults in Australia. The analysis included 106 persons with confirmed ESFT and 344 population-based controls selected randomly via telephone. Information was collected by interview (84% face to face). We found a strong and significant association of ESFT with hernias, in particular hernia repaired in hospital (OR ‫؍‬ 5.6, 95% CI 1.3-6.4). Among other factors, there was a near doubling of risk for males, and male cases had their pubertal signs earlier (started shaving earlier) than male controls. There was also an increased risk of ESFT at higher levels of self-assessed exercise, but no other factor really stood out. For pregnancy-related factors, there was a tripling of risk for glandular fever, a doubling of risk for urinary tract infection and a near doubling of risk for X-rays during or just before pregnancy, but these estimates were not significant. In addition, there was a large number of inverse associations with medical conditions (specifically bone disorders), case exposure to medications, vaccinations and X-rays, with ultrasound during the pregnancy having the most certain effects. We conclude that, although the aetiology of ESFT remains obscure, overall there is strong evidence of an association with inguinal hernia; this can now be added to the farmassociated risk reported by others and us. The other associations reported here await replication and refinement in future studies.

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Section: Discussionmentioning

confidence: 99%

A national case‐control study of Ewing's sarcoma family of tumours in Australia

Valery

McWhirter

Sleigh

et al. 2003

Intl Journal of Cancer

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“…Unpublished studies were sought through personal contacts with published investigators but none were located. We found 5 case-control studies, 2-6 2 conducted in the United States, 2,5 1 in the United States and Canada, 3 1 in Canada 4 and 1 in Australia. 6 Brief description of studies (Table I) Study 1.…”

Section: Identification Of Studiesmentioning

confidence: 91%

“…Buckley et al 3 conducted a case-control study in the United States and Canada that included cases of Ewing's sarcoma and osteosarcoma. Cases, ascertained from the Children's Cancer Group, resided in Canada or the United States at diagnosis, spoke English or Spanish and had a working telephone.…”

Section: Identification Of Studiesmentioning

confidence: 99%

“…The original data sets from the 3 studies included in this analysis were reformatted to produce a common format. We present the pooled findings of the effect of parental occupational exposures from these 3 studies combined in addition to the overall results from a formal meta-analysis using summary measures of the data from 4 studies (Holly et al, 2 Hum et al, 4 Valery et al 6 and Winn et al 5 ) and a sensitivity analysis based on a range of values for study 5 (Buckley et al 3 ).…”

Section: Data Management and Analysismentioning

confidence: 99%

“…Stata statistical software, release 7.0 (Stata, College Station, TX), was used to compute the pooled odds ratios and 95% confidence intervals using a random-effects model. The study by Buckley et al 3 did not specifically report the association between parental occupation and ES, so their data were not included in the meta-analysis.…”

Section: Metaanalysis Of 4 Studiesmentioning

confidence: 99%

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Parental occupation and Ewing's sarcoma: Pooled and meta‐analysis

Valery

Williams

Sleigh

et al. 2005

Intl Journal of Cancer

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Etiologic data on Ewing's sarcoma family of tumors (ESFT) are limited, with only 5 case-control studies reported. Interesting associations, particularly related to parental occupation, have been noted, but results are somewhat inconsistent. We conducted a pooled analysis of 3 case-control studies to assess the overall associations between parental occupation and ESFT. The pooled analysis provided data on parental occupational exposure on 199 cases of ESFT and 1,451 controls. The pooled odds ratio for the periconception and gestation periods were 2.3 (95% CI = 1.3-4.1) for children whose fathers had worked on farms and 3.9 (95% CI = 1.6-9.9) for those whose mothers had farmed. For the periconception and gestation periods, there was a 3.5-fold increased risk for those with both parents having farmed and a doubling of risk for those with at least one parent having farmed; pattern of increasing risk with increasing number of years of postnatal parental exposure to farms was seen. No other occupational group (or more narrowly defined occupations) had other than minor inconsistent associations with the occurrence of ESFT. In addition, we conducted a meta-analysis of farm occupation (a main risk factor) including all 4 case-control studies that collected required information to consider parental occupation. Results of the meta-analysis were consistent with those from the pooled analysis. This collaborative analysis of available individual data on parental occupation and ESFT in the offspring provides evidence supporting the hypothesis of an association between ESFT and parental occupation in farming. ' 2005 Wiley-Liss, Inc.

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