Epidemiology of Oxidative Stress in Male Fertility

Owyong, Michael; Ramasamy, Ranjith

doi:10.1016/b978-0-12-812501-4.00009-2

Cited by 3 publications

(1 citation statement)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Male aging is often associated with DNA repair in defective sperms, which can lead to abnormal chromatin packaging and reduced ability to repair broken DNA strands (21,22).…”

Section: Resultsmentioning

confidence: 99%

Correlation analysis of age and MTHFR C677T polymorphism with sperm motility and sperm DNA integrity

Zenglian Xin,

Ningning Han,

Huiya Jin

2023

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

“…Male aging is often associated with DNA repair in defective sperms, which can lead to abnormal chromatin packaging and reduced ability to repair broken DNA strands (21,22).…”

Section: Resultsmentioning

confidence: 99%

Correlation analysis of age and MTHFR C677T polymorphism with sperm motility and sperm DNA integrity

Zenglian Xin,

Ningning Han,

Huiya Jin

2023

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

Male aging as a causative factor of detrimental changes in human conventional semen parameters and sperm DNA integrity

et al. 2020

View full text Add to dashboard Cite

The effect of male aging on fertility potential is controversial and difficult to predict. The aim of our study was to determine the associations between age, basic semen parameters, and sperm DNA fragmentation (SDF). Comparison of four age-dependent groups (men 29 years, 30-35 years, 36-40 years, and >40 years) revealed a significant fall in the basic semen characteristics and sperm genomic integrity with age. Receiver operating characteristic (ROC) analysis confirmed that men >29 years had lower semen quality. In the group of men >29 years, the prevalence of men with abnormal semen parameters was higher, and these men had over a threefold higher odds ratio (OR) for abnormal semen parameters. Next, ROC analysis revealed that a threshold of 18% SDF was optimal for discriminating between men with normal and abnormal standard semen parameters. The prevalence of men with >18% SDF was higher in the group of men >29 years than in men 29 years. Older men had an almost twofold higher risk for >18% SDF than younger men. Our results suggest that age >29 years may be a causative factor of detrimental changes in semen quality, which may raise the risk for disorders of male fertility potential.

show abstract

Age-related changes in human sperm DNA integrity

Rosiak-Gill

Gill

Jakubik

et al. 2019

Aging

View full text Add to dashboard Cite

Abnormal standard semen characteristics and reduced sperm chromatin maturity can appear with increasing male age. However, the influence of paternal age on semen parameters is still controversial. Therefore, this study was designed to estimate the influence of paternal age not only on conventional semen characteristics but also on sperm DNA integrity. This research was carried out on ejaculated sperm cells obtained from men (n = 1124) aged ≥40 y and <40 y. Our data revealed a decreased semen volume and an increased percentage of DFI (sperm DNA fragmentation index) in older men compared to younger men in the entire study cohort, in men with normozoospermia and in men with abnormal semen parameters. Moreover, there was a higher incidence of sperm DNA damage (>10% DFI, low fertility potential) in the groups of men aged ≥40 y than in the groups of men aged <40 y. Older men had over twice the odds ratio for high sperm DNA damage as younger men. Our findings suggest a detrimental effect of advanced paternal age on sperm chromatin integrity. The data show that the evaluation of sperm DNA has greater clinical utility than standard semen analysis in case of male fertility potential assessment.

show abstract

Epidemiology of Oxidative Stress in Male Fertility

Cited by 3 publications

References 65 publications

Correlation analysis of age and MTHFR C677T polymorphism with sperm motility and sperm DNA integrity

Correlation analysis of age and MTHFR C677T polymorphism with sperm motility and sperm DNA integrity

Male aging as a causative factor of detrimental changes in human conventional semen parameters and sperm DNA integrity

Age-related changes in human sperm DNA integrity

Contact Info

Product

Resources

About